Protein Carbohydrate Interactions In Infectious Diseases

Author : Carole A Bewley
Publisher : Royal Society of Chemistry
ISBN 13 : 1847555330
Total Pages : 265 pages
Book Rating : 4.35/5 ( download)

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Download or read book Protein-Carbohydrate Interactions in Infectious Diseases written by Carole A Bewley and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein-carbohydrate interactions is an exciting area of research with huge potential for development and exploration. These interactions are both widespread and diverse in biological processes and many play a crucial role in cellular recognition, attachment and adhesion. This is particularly true for host-pathogen interactions that lead to infectious diseases; as the surfaces of cells and pathogens display complex carbohydrate structures and carbohydrate binding proteins on their surface. Protein-Carbohydrate Interactions in Infectious Disease is part of the Biomolecular Science Series and provides a comprehensive overview of the subject, with contributions from leading experts in the field. Beginning with a general introduction, subsequent sections include: Atomic basis of protein-carbohydrate interactions, Structures and roles of Pseudomonas areuginosa lectins, Protein-carbohydrate interactions in enterobacterial infections, Retrocyclins: miniature lectins with potent antiviral activity, C-type lectin receptors that regulate pathogen recognition through the recognition of carbohydrates, Synthetic carbohydrate-based anti-malarial vaccines and glycobiology. With full colour throughout and an extensive bibliography this book is ideal for researchers interested in the area.

Author : Jing Shang
Publisher :
ISBN 13 :
Total Pages : 135 pages
Book Rating : 4.68/5 ( download)

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Download or read book Unraveling Carbohydrate-mediated Host-pathogen Interactions written by Jing Shang and published by . This book was released on 2012 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases present a significant challenge to public health, and there is an urgent need to develop new strategies to address bacterial and viral pathogenesis. As the initial interaction between pathogen and the host cell is often mediated by a carbohydrate recognition event, a straightforward and effective strategy to prevent infection is to block host-pathogen protein-carbohydrate binding. By mimicking carbohydrate ligands present on the host mucosa, human milk glycans have been proven to function as soluble inhibitors capable of preventing a variety of pathogens from binding to the host. These glycans hold great promise to be employed as anti-infective prophylactics to combat infectious disease in both pediatric and adult populations. However, among the hundreds of carbohydrate structures found in human milk, it is challenging to establish the inhibitory relationship between discrete glycan entities and specific pathogens. To address this problem and accelerate the development of anti-infective glycans, we apply high-throughput and label-free biosensing platforms for characterizing the anti-viral activities of human milk glycans against norovirus and HIV. Surface plasmon resonance (SPR) and silicon photonic microring resonators are two types of label-free biosensors capable of quantifying binding events in real-time. However, the lack of efficient biofunctionalization strategies limits the application of these devices in characterizing carbohydrate-mediated interactions. In this study, reliable and versatile conjugation methods were developed to functionalize biosensors with carbohydrates. These methods utilize a homobifunctional linker, divinylsulfone (DVS), to conjugate natural sugars or carbohydrates modified with nucleophilic linkers ( -NH2, -SH) onto the sensor surface. Compared to previous immobilization strategies, our DVS-based method greatly simplifies the process for carbohydrate immobilization and demonstrates high stability for biosensing. Next, the carbohydrate-functionalized biosensors were applied to study human milk glycan-norovirus interactions. We identified glycans that bind to two strains of norovirus and confirmed the activity of specific glycans against norovirus-host receptor interactions. Finally, the inhibitory mechanism of human milk glycosaminoglycans (GAGs) against HIV infection was investigated by SPR. The biosensing platforms and the binding studies in this dissertation advance our understanding of the anti-infective mechanism of human milk glycans and promote the application of glycan-based agents to prevent norovirus and HIV infection.

Author : Simon Wong
Publisher : Springer Science & Business Media
ISBN 13 : 9780306478444
Total Pages : 336 pages
Book Rating : 4.47/5 ( download)

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Download or read book Immunobiology of Carbohydrates written by Simon Wong and published by Springer Science & Business Media. This book was released on 2003-10-31 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is unique in providing pertinent information on the various established roles carbohydrate play in the immune system and how the innate and adaptive immune systems respond to this type of microbial antigens. The editors selected only topics that have established basic and clinical relevance to this field. The topics from basic research are organised like a textbook, in order to guide the readers through complex sets of events that lead to clearance of or to immune responses toward carbohydrate antigens. The book is clear, concise and contains fully annotated summaries of the key basic and practical information on carbohydrate immunology from current literature. These topics are written by investigators from various disciplines (chemistry, medicine, biochemistry, glycobiology and immunology), creating a fine balance in the point of views presented in the book. It explores the challenges and rewards of understanding the importance of carbohydrates and glycoconjugates in health and disease, applying new knowledge from carbohydrate immunology in improving or developing novel sugar-based therapeutics, and vaccines and medicines. This book is most suitable for glycobiologists and immunologists, but many researchers whose interests, background and expertise are in any of the fifteen topics presented in this book will also find it appealing. It is also a valuable resource for postgraduate students, clinicians or anyone else who is curious about the role of carbohydrates in immunology, and would like to see the topics combined under one cover and in relation to each other.

Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.18/5 ( download)

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Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Author : René Roy
Publisher : ACS Symposium
ISBN 13 : 9780841239838
Total Pages : 0 pages
Book Rating : 4.35/5 ( download)

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Download or read book Carbohydrate-based Vaccines written by René Roy and published by ACS Symposium. This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of its kind entirely dedicated to carbohydrate vaccines written by renowned scientists with expertise in carbohydrate chemistry and immunochemistry. It covers the synthesis of carbohydrate antigens related to bacteria and parasites such as: Heamophilus influenza, Streptococcus pnemoniae, Shigella flexneri, Candida albicans, Mycobacterium tuberculosis, and Chlamydia. The first three chapters are of wide interest as they cover fundamental concerns in new vaccine developments. The first one presents the immune system and how carbohydrate antigens are processed before protective antibodies are produced. It also illustrates antigen presentation in the context of major histocompatibility complexes (MHCs). The second chapter describes regulatory issues when carbohydrate vaccines are involved while the third one discuss several techniques used in conjugation chemistry and the implication of certain chemical linkages that may induce unexpected anti-linker antibodies. This section will be particularly appealing for those involved in drug-conjugate design, pro-drug developments, and drug vectorization. The book concludes with one chapter that illustrates the principle through which peptide antigens can functionally mimic carbohydrate epitopes, thus, unraveling the potential for peptide surrogates as replacement for complex carbohydrate structures. This book is unique in that it covers all aspects related to carbohydrate vaccines including the success story with the first semi-synthetic bacterial polysaccharide vaccine against Heamophilus influenza type b responsible for pneumonia and meningitis, liable for more than 600,000 infant deaths worldwide in developing countries. The book also presents regulatory issues and will thus be vital for government agencies approving candidate vaccines. It widely covers synthetic methodologies for the attachment of carbohydrate antigens to peptides and immunogenic protein carriers. Vaccines against bacterial antigens, cancer, and parasites are also discussed by worldwide experts in this field in details. No other book contains such a wide panel of different expertise. It will also be useful to students and researchers involved with the immunology of forreings antigens and how the under appreciated carbohydrate antigens are processed by the immune system.

Author : M Michael Gromiha
Publisher : World Scientific
ISBN 13 : 9811211884
Total Pages : 424 pages
Book Rating : 4.81/5 ( download)

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Download or read book Protein Interactions: Computational Methods, Analysis And Applications written by M Michael Gromiha and published by World Scientific. This book was released on 2020-03-05 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is indexed in Chemical Abstracts ServiceThe interactions of proteins with other molecules are important in many cellular activities. Investigations have been carried out to understand the recognition mechanism, identify the binding sites, analyze the the binding affinity of complexes, and study the influence of mutations on diseases. Protein interactions are also crucial in structure-based drug design.This book covers computational analysis of protein-protein, protein-nucleic acid and protein-ligand interactions and their applications. It provides up-to-date information and the latest developments from experts in the field, using illustrations to explain the key concepts and applications. This volume can serve as a single source on comparative studies of proteins interacting with proteins/DNAs/RNAs/carbohydrates and small molecules.

Author : Yann Chevolot
Publisher : Humana Press
ISBN 13 : 9781617793721
Total Pages : 427 pages
Book Rating : 4.28/5 ( download)

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Download or read book Carbohydrate Microarrays written by Yann Chevolot and published by Humana Press. This book was released on 2011-11-09 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate microarrays emerged as a key technology for the deciphering of the glycospace by providing a multiplex technology where tens to hundreds of carbohydrates/protein interactions can be probed in parallel. Carbohydrate Microarrays: Methods and Protocols aims to give the reader the theoretical and experimental clues necessary for the fabrication and implementation of carbohydrate microarrays. This requires three essential steps: 1) to obtain the carbohydrate probes (monosacharides, oligosacchrides, polysacchairdes, glycoconjugates or glycoclusters), 2) to immobilize these probes, and 3) to implement the protocols for biological/biochemical interaction with the desired target. This volume gives an overview of carbohydrate microarray and carbohydrate chemistry and illustrates different detection techniques and their applications. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Carbohydrate Microarrays: Methods and Protocols compiles a catalogue of protocols on carbohydrate microarrays to span the needs of researchers around the globe.

Author : Hans-Joachim Böhm
Publisher : John Wiley & Sons
ISBN 13 : 3527605517
Total Pages : 262 pages
Book Rating : 4.14/5 ( download)

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Download or read book Protein-Ligand Interactions written by Hans-Joachim Böhm and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed. An up-to-date presentation of an eternally young topic, this book is an indispensable information source for chemists, biochemists and pharmacologists dealing with the binding of ligands to proteins.

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.81/5 ( download)

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Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Erwin Neter
Publisher :
ISBN 13 :
Total Pages : 568 pages
Book Rating : 4.21/5 ( download)

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Download or read book The Immune System and Infectious Diseases written by Erwin Neter and published by . This book was released on 1975 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: