The Prevention and Treatment of Missing Data in Clinical Trials

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Author :
Publisher : National Academies Press
ISBN 13 : 030918651X
Total Pages : 163 pages
Book Rating : 4.13/5 ( download)

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Book Synopsis The Prevention and Treatment of Missing Data in Clinical Trials by : National Research Council

Download or read book The Prevention and Treatment of Missing Data in Clinical Trials written by National Research Council and published by National Academies Press. This book was released on 2010-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.

Reducing Risks for Mental Disorders

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Publisher : National Academies Press
ISBN 13 : 0309049393
Total Pages : 636 pages
Book Rating : 4.99/5 ( download)

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Book Synopsis Reducing Risks for Mental Disorders by : Institute of Medicine

Download or read book Reducing Risks for Mental Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: The understanding of how to reduce risk factors for mental disorders has expanded remarkably as a result of recent scientific advances. This study, mandated by Congress, reviews those advances in the context of current research and provides a targeted definition of prevention and a conceptual framework that emphasizes risk reduction. Highlighting opportunities for and barriers to interventions, the book draws on successful models for the prevention of cardiovascular disease, injuries, and smoking. In addition, it reviews the risk factors associated with Alzheimer's disease, schizophrenia, alcohol abuse and dependence, depressive disorders, and conduct disorders and evaluates current illustrative prevention programs. The models and examination provide a framework for the design, application, and evaluation of interventions intended to prevent mental disorders and the transfer of knowledge about prevention from research to clinical practice. The book presents a focused research agenda, with recommendations on how to develop effective intervention programs, create a cadre of prevention researchers, and improve coordination among federal agencies.

A Guide to Conducting Prevention Research in the Community

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Author :
Publisher : Routledge
ISBN 13 : 1317736222
Total Pages : 187 pages
Book Rating : 4.26/5 ( download)

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Book Synopsis A Guide to Conducting Prevention Research in the Community by : James G Kelly

Download or read book A Guide to Conducting Prevention Research in the Community written by James G Kelly and published by Routledge. This book was released on 2014-02-04 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This provocative and useful volume is a step-by-step guide to assist professionals in implementing valid and useful community research and creating preventive interventions that have positive and lasting effects on the development of the community. The authors--including James G. Kelly, one of the fathers of prevention--offer valuable suggestions for developing community processes to assist the prevention researcher and the community in designing research that is embedded in the community. Experts focus on the topics that can help establish and sustain effective long-term working relationships with community members. Numerous examples illustrate how the collaborative working relationship can create the variety of resources that are needed to eventually implement policy changes stimulated by the research and help to sustain the impact of the research findings after the research has been completed. This exciting book illustrates how community research related to the prevention of mental illness and the promotion of mental health can be scientific and objective, as well as a positive collaboration between the research staff and community members. Focus upon community needs Emphasize educational activities to support the prevention research Identify points of policy impact before the research begins Enhance the development of social networks and social support systems for the development of competencies Provide criteria for the selection of systemic variables for the research Include reference to the multiple levels of a community which may affect the research topic Specify ways in which participants can identify and own the research topic Outline criteria for assessing the side effects of the prevention research In order to better understand the needs, values, commitments, and resources of the community in which he or she is working, the researcher is encouraged to select research topics derived from underlying community needs, educated the public about prevention, identify points of policy impact, and determine the informal social networks that enhance the development of social competencies in the community. The benefits of the collaborative relationship between prevention researchers and the community are strongly emphasized. A Guide to Conducting Prevention Research in the Community aims to guide citizens and professionals in implementing valid and useful community research and create preventive interventions that have positive and lasting effects on the development of the community.

A Guide to Conducting Prevention Research in the Community

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Author :
Publisher : Routledge
ISBN 13 : 1317736214
Total Pages : 194 pages
Book Rating : 4.19/5 ( download)

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Book Synopsis A Guide to Conducting Prevention Research in the Community by : James G Kelly

Download or read book A Guide to Conducting Prevention Research in the Community written by James G Kelly and published by Routledge. This book was released on 2014-02-04 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This provocative and useful volume is a step-by-step guide to assist professionals in implementing valid and useful community research and creating preventive interventions that have positive and lasting effects on the development of the community. The authors--including James G. Kelly, one of the fathers of prevention--offer valuable suggestions for developing community processes to assist the prevention researcher and the community in designing research that is embedded in the community. Experts focus on the topics that can help establish and sustain effective long-term working relationships with community members. Numerous examples illustrate how the collaborative working relationship can create the variety of resources that are needed to eventually implement policy changes stimulated by the research and help to sustain the impact of the research findings after the research has been completed. This exciting book illustrates how community research related to the prevention of mental illness and the promotion of mental health can be scientific and objective, as well as a positive collaboration between the research staff and community members. Focus upon community needs Emphasize educational activities to support the prevention research Identify points of policy impact before the research begins Enhance the development of social networks and social support systems for the development of competencies Provide criteria for the selection of systemic variables for the research Include reference to the multiple levels of a community which may affect the research topic Specify ways in which participants can identify and own the research topic Outline criteria for assessing the side effects of the prevention research In order to better understand the needs, values, commitments, and resources of the community in which he or she is working, the researcher is encouraged to select research topics derived from underlying community needs, educated the public about prevention, identify points of policy impact, and determine the informal social networks that enhance the development of social competencies in the community. The benefits of the collaborative relationship between prevention researchers and the community are strongly emphasized. A Guide to Conducting Prevention Research in the Community aims to guide citizens and professionals in implementing valid and useful community research and create preventive interventions that have positive and lasting effects on the development of the community.

Reducing the Burden of Injury

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Publisher : National Academies Press
ISBN 13 : 0309593468
Total Pages : 336 pages
Book Rating : 4.65/5 ( download)

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Book Synopsis Reducing the Burden of Injury by : Committee on Injury Prevention and Control

Download or read book Reducing the Burden of Injury written by Committee on Injury Prevention and Control and published by National Academies Press. This book was released on 1999-01-04 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Injuries are the leading cause of death and disability among people under age 35 in the United States. Despite great strides in injury prevention over the decades, injuries result in 150,000 deaths, 2.6 million hospitalizations, and 36 million visits to the emergency room each year. Reducing the Burden of Injury describes the cost and magnitude of the injury problem in America and looks critically at the current response by the public and private sectors, including: Data and surveillance needs. Research priorities. Trauma care systems development. Infrastructure support, including training for injury professionals. Firearm safety. Coordination among federal agencies. The authors define the field of injury and establish boundaries for the field regarding intentional injuries. This book highlights the crosscutting nature of the injury field, identifies opportunities to leverage resources and expertise of the numerous parties involved, and discusses issues regarding leadership at the federal level.

Intervention Research

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Publisher : Springer
ISBN 13 : 9811010110
Total Pages : 173 pages
Book Rating : 4.18/5 ( download)

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Book Synopsis Intervention Research by : Nyanda McBride

Download or read book Intervention Research written by Nyanda McBride and published by Springer. This book was released on 2016-08-01 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a step-by-step guide to intervention research, including the methods and techniques that researchers, higher degree research students and others can use when pursuing intervention research in schools and other settings. Guided by the Intervention Research Framework, it also provides practical information on linking a program developed using a comprehensive, evidence-based approach, to research and evaluation processes. The handbook also illustrates how to select an appropriate research sample for research; how to develop valid and reliable instruments for measuring change, including how to devise appropriate measures for assessing behavioural change; how to recruit and negotiate with schools (and other settings) for research involving young people; how to measure and incorporate measures of fidelity of implementation to understand dose response and behavior change; and how to optimize data collection and dissemination. The development and longitudinal assessment of the multi award-winning School Health and Alcohol Harm Reduction Project (SHAHRP) – the first alcohol harm reduction study to assess the impact of a school-based classroom intervention on alcohol use, alcohol-related behaviors and alcohol-related harm using a harm reduction paradigm – provides a practical example of the intervention research processes described in this handbook.

Handbook of HIV Prevention

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Publisher : Springer Science & Business Media
ISBN 13 : 1461541379
Total Pages : 368 pages
Book Rating : 4.70/5 ( download)

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Book Synopsis Handbook of HIV Prevention by : John L. Peterson

Download or read book Handbook of HIV Prevention written by John L. Peterson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook provides a comprehensive overview of the theories, methods and approaches for reducing HIV-associated risk behaviors. It represents the first single source of information about HIV prevention research in developed and developing countries. It will be an important resource for students, researchers and clinicians in the field.

Linking Research and Public Health Practice

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Publisher : National Academies Press
ISBN 13 : 0309174864
Total Pages : 119 pages
Book Rating : 4.62/5 ( download)

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Book Synopsis Linking Research and Public Health Practice by : Institute of Medicine

Download or read book Linking Research and Public Health Practice written by Institute of Medicine and published by National Academies Press. This book was released on 1997-01-31 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health promotion and disease prevention are central priorities in the Centers for Disease Control and Prevention (CDC) vision. To advance research in these areas, Congress authorized and CDC established a program of university-based Centers for Research and Demonstration of Health Promotion and Disease Prevention to explore improved ways of appraising health hazards and to serve as demonstration sites for new and innovative research in public health. Begun in 1986 with three centers, there are now fourteen. In response to a CDC request to evaluate the program, Linking Research and Public Health Practice examines the vision for the prevention research centers program, the projects conducted by the centers, and the management and oversight of the program. In conducting the evaluation, the IOM committee took a broad view of how prevention research can influence the health of communities, and considered both the proximal risk factors for disease prevention and the more distal conditions for health promotion and improved equity in the distribution of risk factors. Month?

The Fast Track Program for Children at Risk

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Author :
Publisher : Guilford Publications
ISBN 13 : 1462541291
Total Pages : 241 pages
Book Rating : 4.94/5 ( download)

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Book Synopsis The Fast Track Program for Children at Risk by : Conduct Problems Prevention Research Group

Download or read book The Fast Track Program for Children at Risk written by Conduct Problems Prevention Research Group and published by Guilford Publications. This book was released on 2019-10-30 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The authors conducted a prevention program called Fast Track, consisting of multicomponent, home-school prevention activities carried out with at-risk children from first to 10th grades over a 10-year period, to prevent serious antisocial behavior and youth violence and achieve positive social, emotional, and academic outcomes. They describe the research that informed the design of the program as part of their Conduct Problems Prevention Research Group, how the study was implemented, and outcomes up to 20 years later. They discuss the context for youth violence prevention in the US; the developmental and intervention research that informed the design of the program; the study design and the children and families who participated in it; interventions and impacts in elementary, middle, and high school years; early adult outcomes of the program; implications for developmental theory and research on the prevention of violence; and how communities can address the problem of future violence by focusing on high-risk young children."--Provided by publisher.

Relieving Pain in America

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Publisher : National Academies Press
ISBN 13 : 030921484X
Total Pages : 383 pages
Book Rating : 4.41/5 ( download)

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Book Synopsis Relieving Pain in America by : Institute of Medicine

Download or read book Relieving Pain in America written by Institute of Medicine and published by National Academies Press. This book was released on 2011-10-26 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.