Predicting Chemical Toxicity And Fate

Author : Mark T.D. Cronin
Publisher : CRC Press
ISBN 13 : 9780203642627
Total Pages : 474 pages
Book Rating : 4.27/5 ( download)

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Download or read book Predicting Chemical Toxicity and Fate written by Mark T.D. Cronin and published by CRC Press. This book was released on 2004-05-10 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Structure-Activity Relationships (QSARs) are increasingly used to predict the harmful effects of chemicals to humans and the environment. The increased use of these methods in a variety of areas (academic, industrial, regulatory) results from a realization that very little toxicological or fate data is available on the vast amount of chemicals to which humans and the environment are exposed. Predicting Chemical Toxicity and Fate provides a comprehensive explanation of the state-of-the-art methods that are available to predict the effects of chemicals on humans and the environment. It describes the use of predictive methods to estimate the physiochemical properties, biological activities, and fate of chemicals. The methods described may be used to predict the properties of drugs before their development, and to predict the environmental effects of chemicals. These methods also reduce the cost of product development and the need for animal testing. This book fills an obvious need by providing a comprehensive explanation of these prediction methods. It is a practical book that illustrates the use of these techniques in real life scenarios. This book will demystify QSARs for those students unsure of them, and professionals in environmental toxicology and chemistry will find this a useful reference in their everyday working lives.

Author : P. S. Rainbow
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 246 pages
Book Rating : 4.52/5 ( download)

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Download or read book Forecasting the Environmental Fate and Effects of Chemicals written by P. S. Rainbow and published by John Wiley & Sons. This book was released on 2001-05-25 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forecasting the Environmental Fate and Effects of Chemicals is the first book to address specifically the issue of forecasting in environmental toxicology and chemistry from a methodological, regulatory and practical perspective. It is becoming increasingly important for environmental toxicologists and chemists to be able to forecast the fate and effects of chemicals by using existing information to predict the future. Providing a unique and timely opportunity for active researchers and students to obtain in a single volume the 'state of the art' in this expanding field, this text discusses how forecasts can be made by: * using ecotoxicological endpoints at different levels of biological organisation * measuring and modelling chemical fate in biotic and abiotic environments * adopting difference quantitative frameworks Written by an international team of scientists, this text will be essential reading for postgraduate and advance undergraduate students studying ecotoxicology, toxicology, chemistry and environmental statistics aswell as industrial and academic research scientists in environmental toxicology, environmental chemistry and those involved in risk management.

Author : Mark T. D. Cronin
Publisher : Royal Society of Chemistry
ISBN 13 : 1849730040
Total Pages : 689 pages
Book Rating : 4.44/5 ( download)

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Download or read book In Silico Toxicology written by Mark T. D. Cronin and published by Royal Society of Chemistry. This book was released on 2010 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book defines the use of computational approaches to predict the environmental toxicity and human health effects of organic chemicals.

Author : Christoph Helma
Publisher : CRC Press
ISBN 13 : 0849350352
Total Pages : 522 pages
Book Rating : 4.51/5 ( download)

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Download or read book Predictive Toxicology written by Christoph Helma and published by CRC Press. This book was released on 2005-03-17 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of techniques and systems currently utilized in predictive toxicology, this reference presents an in-depth survey of strategies, algorithms, and prediction methods to select, calculate, and represent the features and properties of chemical structures in biological systems. It provides sources of high-quality toxicity data, the most important commercial and noncommercial predictive toxicology programs, and advanced technologies in computational chemistry, biology, statistics, and data mining. Predictive Toxicology explores applications that go beyond classical structure-activity relationships and discusses programs such as OncoLogic, META, MC4PC, PASS, and lazar.

Author : Y. Samiullah
Publisher : Springer
ISBN 13 : 9789401074926
Total Pages : 285 pages
Book Rating : 4.25/5 ( download)

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Download or read book Prediction of the Environmental Fate of Chemicals written by Y. Samiullah and published by Springer. This book was released on 2011-09-20 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concern over the effects of chemicals in the environment has been increasing for many years. Environmental contamination by DDT, Aldrin, Dieldrin, mercury, PCBs, organotins and many other sub stances are all part of the public consciousness and have led to widespread attention to this topic. Some of the concerns have arisen because human health has been affected when contaminants have been consumed via the food chain-for instance in the case of 'Minimata disease' in Japan. In other cases, direct effects on other components of ecosystems have given cause for alarm. The toxic effects which any chemical can cause are a function of exposure and innate toxicity, i.e. of the ability to reach in sufficient quantity a site where a biological process can be disrupted and of the tendency to cause disruption when it gets there. The processes by which chemicals reach sites of toxic action are the subject of this book, and are a fundamental consideration in ecotoxi cology. When a chemical enters the environment e.g. via a spillage or in an effluent, it is potentially subject to a wide variety of processes which may eliminate it from the environment completely, modify it into a more or less harmful substance, or transfer it to another part of the environment. The processes involved are complex and highly variable, but it is essential to increase our understanding of them.

Author : Li Di
Publisher : Elsevier
ISBN 13 : 0080557619
Total Pages : 549 pages
Book Rating : 4.18/5 ( download)

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Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Author : Kunal Roy
Publisher : John Wiley & Sons
ISBN 13 : 1119681596
Total Pages : 596 pages
Book Rating : 4.95/5 ( download)

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Download or read book Chemometrics and Cheminformatics in Aquatic Toxicology written by Kunal Roy and published by John Wiley & Sons. This book was released on 2022-01-06 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: CHEMOMETRICS AND CHEMINFORMATICS IN AQUATIC TOXICOLOGY Explore chemometric and cheminformatic techniques and tools in aquatic toxicology Chemometrics and Cheminformatics in Aquatic Toxicology delivers an exploration of the existing and emerging problems of contamination of the aquatic environment through various metal and organic pollutants, including industrial chemicals, pharmaceuticals, cosmetics, biocides, nanomaterials, pesticides, surfactants, dyes, and more. The book discusses different chemometric and cheminformatic tools for non-experts and their application to the analysis and modeling of toxicity data of chemicals to various aquatic organisms. You’ll learn about a variety of aquatic toxicity databases and chemometric software tools and webservers as well as practical examples of model development, including illustrations. You’ll also find case studies and literature reports to round out your understanding of the subject. Finally, you’ll learn about tools and protocols including machine learning, data mining, and QSAR and ligand-based chemical design methods. Readers will also benefit from the inclusion of: A thorough introduction to chemometric and cheminformatic tools and techniques, including machine learning and data mining An exploration of aquatic toxicity databases, chemometric software tools, and webservers Practical examples and case studies to highlight and illustrate the concepts contained within the book A concise treatment of chemometric and cheminformatic tools and their application to the analysis and modeling of toxicity data Perfect for researchers and students in chemistry and the environmental and pharmaceutical sciences, Chemometrics and Cheminformatics in Aquatic Toxicology will also earn a place in the libraries of professionals in the chemical industry and regulators whose work involves chemometrics.

Author : Mohammad Oves
Publisher : Springer
ISBN 13 : 3030082830
Total Pages : 360 pages
Book Rating : 4.33/5 ( download)

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Download or read book Modern Age Waste Water Problems written by Mohammad Oves and published by Springer. This book was released on 2019-06-12 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a picture of the advances in the research of theoretical and practical frameworks of wastewater problems and solutions. The book deals with a basic concept and principles of modern biological, chemical and technical approaches to remediate various hazardous pollutants from wastewater. The latest empirical research findings in wastewater treatment are comprehensively discussed. Examples of low-cost technologies are also included. The book is written for professionals, researchers, academics and students wanting to improve their understanding of the strategic role of environmental protection and advanced applied technologies.

Author : Gary M. Rand
Publisher : CRC Press
ISBN 13 : 100016294X
Total Pages : 1152 pages
Book Rating : 4.43/5 ( download)

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Download or read book Fundamentals Of Aquatic Toxicology written by Gary M. Rand and published by CRC Press. This book was released on 2020-08-06 with total page 1152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is divided into three parts. The first part describes basic toxicological concepts and methodologies used in aquatic toxicity testing, including the philosophies underlying testing strategies now required to meet and support regulatory standards. The second part of the book discusses various factors that affect transport, transformation, ultimate distribution, and accumulation of chemicals in the aquatic environment, along with the use of modelling to predict fate.; The final section of the book reviews types of effects or endpoints evaluated in field studies and the use of structure-activity relationships in aquatic toxicology to predict biological activity and physio-chemical properties of a chemical. This section also contains an extensive background of environmental legislation in the USA and within the European Community, and an introduction to hazard/risk assessment with case studies.

Author : Cornelis A. M. van Gestel
Publisher : CRC Press
ISBN 13 : 1439830096
Total Pages : 312 pages
Book Rating : 4.93/5 ( download)

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Download or read book Mixture Toxicity written by Cornelis A. M. van Gestel and published by CRC Press. This book was released on 2016-04-19 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an