Precision Medicine In Practice Molecular Diagnosis Enabling Precision Therapies An Issue Of The Clinics In Laboratory Medicine

Author : Ryan J. Schmidt
Publisher : Elsevier Health Sciences
ISBN 13 : 0323758460
Total Pages : 129 pages
Book Rating : 4.68/5 ( download)

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Download or read book Precision Medicine in Practice: Molecular Diagnosis Enabling Precision Therapies, An Issue of the Clinics in Laboratory Medicine written by Ryan J. Schmidt and published by Elsevier Health Sciences. This book was released on 2020-06-21 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine will cover Precision Medicine in Practice: Molecular Diagnosis Enabling Precision Therapies. Curated by Dr. Ryan J. Schmidt, this issue is one of four selected each year by the series Consulting Editor, Milenko Tanasijevic. The volume will include articles on: Features of a Comprehensive Precision Medicine Program for Constitutional Genetic Disorders, Establishing a Precision Medicine Center of Excellence for Rare Disease, High-throughput DNA Sequencing for Rare Disease Diagnosis, Enhancing Diagnosis through RNA Sequencing, Interpretation of Rare Genetic Variants, Clinical Bioinformatics, Precision Therapies for Retinal Dystrophy, Precision Therapies for Muscular Dystrophy, Therapeutic Gene Editing, High Throughput Functional Studies of Genetic Variants, and Patient-specific Disease Models.

Author : Ryan J. Schmidt
Publisher : Elsevier
ISBN 13 : 9780323758451
Total Pages : 240 pages
Book Rating : 4.52/5 ( download)

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Download or read book Precision Medicine in Practice: Molecular Diagnosis Enabling Precision Therapies, an Issue of the Clinics in Laboratory Medicine, Volume 40-2 written by Ryan J. Schmidt and published by Elsevier. This book was released on 2020-06-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine will cover Precision Medicine in Practice: Molecular Diagnosis Enabling Precision Therapies. Curated by Dr. Ryan J. Schmidt, this issue is one of four selected each year by the series Consulting Editor, Milenko Tanasijevic. The volume will include articles on: Features of a Comprehensive Precision Medicine Program for Constitutional Genetic Disorders, Establishing a Precision Medicine Center of Excellence for Rare Disease, High-throughput DNA Sequencing for Rare Disease Diagnosis, Enhancing Diagnosis through RNA Sequencing, Interpretation of Rare Genetic Variants, Clinical Bioinformatics, Precision Therapies for Retinal Dystrophy, Precision Therapies for Muscular Dystrophy, Therapeutic Gene Editing, High Throughput Functional Studies of Genetic Variants, and Patient-specific Disease Models.

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309381347
Total Pages : 293 pages
Book Rating : 4.45/5 ( download)

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Download or read book Biomarker Tests for Molecularly Targeted Therapies written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-07-30 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every patient is unique, and the evolving field of precision medicine aims to ensure the delivery of the right treatment to the right patient at the right time. In an era of rapid advances in biomedicine and enhanced understanding of the genetic basis of disease, health care providers increasingly have access to advanced technologies that may identify molecular variations specific to an individual patient, which subsequently can be targeted for treatment. Known as biomarker tests for molecularly targeted therapies, these complex tests have the potential to enable the selection of the most beneficial treatment (and also to identify treatments that may be harmful or ineffective) for the molecular underpinnings of an individual patient's disease. Such tests are key to unlocking the promise of precision medicine. Biomarker tests for molecularly targeted therapies represent a crucial area of focus for developing methods that could later be applicable to other areas of precision medicine. The appropriate regulatory oversight of these tests is required to ensure that they are accurate, reliable, properly validated, and appropriately implemented in clinical practice. Moreover, common evidentiary standards for assessing the beneficial impact of biomarker-guided therapy selection on patient outcomes, as well as the effective collection and sharing of information related to those outcomes, are urgently needed to better inform clinical decision making. Biomarker Tests of Molecularly Targeted Therapies examines opportunities for and challenges to the use of biomarker tests to select optimal therapy and offers recommendations to accelerate progress in this field. This report explores regulatory issues, reimbursement issues, and clinical practice issues related to the clinical development and use of biomarker tests for targeting therapies to patients. Properly validated, appropriately implemented biomarker tests hold the potential to enhance patient care and improve outcomes, and therefore addressing the challenges facing such tests is critical.

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309462630
Total Pages : 145 pages
Book Rating : 4.31/5 ( download)

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Download or read book Enabling Precision Medicine written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-11-17 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine. On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development. Participants examined successes, challenges, and possible best practices for effectively using genetic information in the design and implementation of clinical trials to support the development of precision medicines, including exploring the potential advantages and disadvantages of such trials across a variety of disease areas. This publication summarizes the presentations and discussions from the workshop.

Author : Somchai Chutipongtanate
Publisher : Bentham Science Publishers
ISBN 13 : 9815036769
Total Pages : 256 pages
Book Rating : 4.63/5 ( download)

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Download or read book Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine written by Somchai Chutipongtanate and published by Bentham Science Publishers. This book was released on 2021-12-13 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision medicine is a disruptive innovation with a fast-evolving pace in the healthcare ecosystem. Precision medicine enables precise diagnosis and targeted treatment by considering individual variability in the abnormalities of causative genes and molecular drivers behind biochemical mechanisms. A vast amount of data created by advanced omics technologies is a foundation of precision medicine’s success, and the implications of the findings from these technologies can potentially improve clinical outcomes. Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine presents essential information of molecular and translational research in precision medicine, with a specific focus on pediatrics. This book provides an accessible introduction to omics technologies, gives a detailed explanation of bioinformatics workflows to interpret high-throughput omics profiles for molecular diagnosis, and collects some of the cutting-edge research for precise therapeutics. Contributions to the book have been provided by experts in biomedical engineering and clinical practice, thus, bringing an informed perspective to the reader on each topic. The book is a valuable resource for postgraduate students, researchers, data scientists and clinicians interested in precision medicine, as well as researchers in the field of genetics and pediatrics who are interested in understanding the role of precision medicine in clinical practice.

Author : Vinay Subash Mahajan
Publisher : Elsevier Health Sciences
ISBN 13 : 0323711588
Total Pages : 240 pages
Book Rating : 4.86/5 ( download)

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Download or read book Immunology Laboratory Testing,An Issue of the Clinics in Laboratory Medicine written by Vinay Subash Mahajan and published by Elsevier Health Sciences. This book was released on 2019-11-02 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine, guest edited by Dr. Vinay Subhash Mahajan, will focus on Immunology Laboratory Testing. Topics include, but are not limited to, Analysis of proteins and immunoglobulins in the clinical immunology laboratory; Antinuclear antibody tests; Serological diagnosis of rheumatoid arthritis; ANCA; Anti-phospholipid antibodies; Diagnostic pitfalls in autoantibody testing; Analysis of the complement pathway; Flow cytometric analysis of immune cell subsets; Testing of cellular immune function in immunodeficiencies; Food allergy testing; Evaluation of the immune response in transplantation; Laboratory testing in the context of biologics and cellular therapies; Testing immune-related adverse-events in cancer immunotherapy; Molecular diagnosis of inherited immune disorders; and Future of immunology lab testing.

Author : Sarah Vossoughi
Publisher : Elsevier Health Sciences
ISBN 13 : 0323763154
Total Pages : 185 pages
Book Rating : 4.58/5 ( download)

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Download or read book Topics in Pediatric Transfusion Medicine, An Issue of the Clinics in Laboratory Medicine written by Sarah Vossoughi and published by Elsevier Health Sciences. This book was released on 2021-01-28 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guest edited by Drs Sarah Vossoughi and Brie Stotler, this issue of Clinics in Laboratory Medicine will cover several key areas of interest related to Pediatric Transfusion Medicine. This issue is one of four selected each year by our series Consulting Editor, Dr. Milenko Tanasijevic. Articles in this issue include but are not limited to: Transfusion in the Pediatric Patient: Review of Evidence Based Guidelines, Transfusion in the Neonatal Patient: Review of Evidence Based Guidelines, Massive Transfusion in the Pediatric Patient, Pediatric Hemovigilance and Adverse Transfusion Reactions, Inventory Management and Product Selection in Pediatric Blood Banking, Evaluation and Management of Coagulopathies and Thrombophilias in the Pediatric Patient, Transfusion and Cellular Therapy in Pediatric Sickle Cell Disease, Cellular Therapy in Pediatric Hematologic Malignancies, Hemolytic Disease of the Fetus and Newborn: Historical and Current State, Novel Blood Component Therapies in the Pediatric Setting, and more.

Author : Kristen Reynolds
Publisher : Elsevier Health Sciences
ISBN 13 : 0323462804
Total Pages : 177 pages
Book Rating : 4.08/5 ( download)

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Download or read book Pharmacogenomics and Precision Medicine, An Issue of the Clinics in Laboratory Medicine written by Kristen Reynolds and published by Elsevier Health Sciences. This book was released on 2016-08-16 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of the Clinics in Laboratory Medicine on “Pharmacogenomics is being edited by Drs. Roland Valdes and Kristen Reynolds and will cover a wide variety of topics, including but not limited to, fundamentals of pharmacology, a review of pharmacogenetics guidelines, pharmacogenetic testing in pain management, pharmacogenetics of pain management, clinical and economic impact of pharmacogenetic genotyping analysis, exosome analysis in lab medicine, and implementation of pharmacogenetics in developing countries.

Author : A. Zara Herskovits
Publisher : Elsevier Health Sciences
ISBN 13 : 0323762697
Total Pages : 161 pages
Book Rating : 4.94/5 ( download)

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Download or read book Laboratory Testing for Neurologic Disorders, An Issue of the Clinics in Laboratory Medicine written by A. Zara Herskovits and published by Elsevier Health Sciences. This book was released on 2020-08-28 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine, guest edited by Dr. A. Zara Herskovits, will cover Laboratory Testing for Neurologic Disorders. This issue is one of four selected each year by our Editor-in-Chief, Dr. Milenko Jovan Tanasijevic. Topics discussed in this issue will include: molecular approach to diagnostic testing for children with developmental delay and congenital anomalies, proteopathic and seeding assays (such as RT-QUIC), genetic testing for ALS and FTD, Diagnostic and prognostic testing for Alzheimer’s disease, confounds in the interpretation of paraneoplastic antibody panels, Review of neurologic disease sendout testing at an academic medical center, development of new diagnostic tests for neurologic disorders, assuring quality in laboratory testing for sendout reference tests, diagnostic testing for patients with spinal muscular atrophy, among others.

Author : Nicole Pecora
Publisher : Elsevier Health Sciences
ISBN 13 : 0323733964
Total Pages : 257 pages
Book Rating : 4.60/5 ( download)

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Download or read book Current Issues in Clinical Microbiology, An Issue of the Clinics in Laboratory Medicine, E-Book written by Nicole Pecora and published by Elsevier Health Sciences. This book was released on 2020-11-11 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Clinics in Laboratory Medicine, guest edited by Drs. Nicole D. Pecora and Matthew Pettengill, will cover Current Issues in Clinical Microbiology. This issue is one of four selected each year by our Editor-in-Chief, Dr. Milenko Jovan Tanasijevic. Topics discussed in this issue will include: Update in Diagnostics of Bloodstream Infections, Panels and Syndromic Testing in Clinical Microbiology, Lab Consolidation and Centralization, Update in Susceptibility Testing: Phenotypic and Genotypic Methods, Genomics in the Clinical Microbiology Laboratory, Automation in the Clinical Microbiology Laboratory, Coronavirus Detection in the Clinical Microbiology Laboratory: Are We Ready for Identifying and Diagnosing a Novel Strain?, Update on Biosafety and Emerging Infections for the Clinical Microbiology Lab, Update in Clinical Mycology, Point of Care Testing in Microbiology, Pediatric Diagnostic Microbiology, Antimicrobial Stewardship: What the Clinical Laboratory Needs to Know, Fellowship Training for the Future Clinical Microbiology Laboratory Director, Update in Diagnostics/Susceptibility of Mycobacterial Diseases, Role of the Clinical Microbiology Lab in One Health, Update in Infectious Disease Diagnosis in Surgical Pathology, and more.