Polymers And Nanomaterials For Gene Therapy

Author : Ravin Narain
Publisher : Woodhead Publishing
ISBN 13 : 0081005210
Total Pages : 302 pages
Book Rating : 4.17/5 ( download)

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Download or read book Polymers and Nanomaterials for Gene Therapy written by Ravin Narain and published by Woodhead Publishing. This book was released on 2016-01-09 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications

Author : Mansoor M. Amiji
Publisher : CRC Press
ISBN 13 : 0203500474
Total Pages : 707 pages
Book Rating : 4.77/5 ( download)

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Download or read book Polymeric Gene Delivery written by Mansoor M. Amiji and published by CRC Press. This book was released on 2004-09-29 with total page 707 pages. Available in PDF, EPUB and Kindle. Book excerpt: To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry

Author : Yiyun Cheng
Publisher : Springer
ISBN 13 : 3319778668
Total Pages : 358 pages
Book Rating : 4.62/5 ( download)

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Download or read book Polymeric Gene Delivery Systems written by Yiyun Cheng and published by Springer. This book was released on 2018-09-04 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : Surendra Nimesh
Publisher : CRC Press
ISBN 13 : 1000819280
Total Pages : 139 pages
Book Rating : 4.81/5 ( download)

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Download or read book Theory, Techniques and Applications of Nanotechnology in Gene Silencing written by Surendra Nimesh and published by CRC Press. This book was released on 2022-09-01 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on various aspects of nanotechnology based gene silencing. The initial chapters detail the techniques available for in vitro and in vivo characterization of nanoparticles. In the later chapters, exhaustive details about various polymeric systems employed for gene silencing has been accounted.

Author : Surendra Nimesh
Publisher : Elsevier
ISBN 13 : 1908818646
Total Pages : 380 pages
Book Rating : 4.45/5 ( download)

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Download or read book Gene therapy written by Surendra Nimesh and published by Elsevier. This book was released on 2013-10-31 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors form condensed complexes with DNA which result in shielding against enzymatic degradation and enhanced cellular targeting. Advantages including easy manipulatibility, high stability, low cost and high payload, mean that nanoparticles from various polymers have been exploited. Gene therapy gives a systematic account of the many aspects of nanotechnology mediated gene therapy, from the preparation of nanoparticles to physicochemical characterization, and follows with applications in in vitro and in vivo models. This book emphasizes the various aspects of nanotechnology-based gene therapy, with initial chapters detailing the tools and techniques available for preparation and in vitro and in vivo characterization of nanoparticles. Later chapters provide exhaustive details on polymeric systems employed for gene therapy. Provides an overview of nanotechnology applications in gene therapy, from preparation of nanoparticles to in vitro and in vivo studies Details the tools and techniques available for preparation, characterization and in vitro and in vivo study of nanoparticles Details the limitations of nanoparticle-mediated gene therapy and proposes ways in which they may be overcome

Author :
Publisher : Academic Press
ISBN 13 : 0128003677
Total Pages : 437 pages
Book Rating : 4.71/5 ( download)

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Download or read book Nonviral Vectors for Gene Therapy written by and published by Academic Press. This book was released on 2014-11-18 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Includes methods for testing with ethical, legal, and social implications Critically analyzes future directions Written and edited by recognized leaders in the field

Author : Donglu Shi
Publisher : World Scientific
ISBN 13 : 9814616931
Total Pages : 256 pages
Book Rating : 4.35/5 ( download)

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Download or read book Bio-Inspired Nanomaterials and Applications written by Donglu Shi and published by World Scientific. This book was released on 2014-11-18 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book intends to provide an up-to-date information in the field of nanobiomedicine. The focus of the book is on the basic concepts and recent developments in the field of nanotechnology. This book covers a broad spectrum of nanomaterials processing, structural characteristics, and related properties and will include bio-probes, medical imaging, drug delivery, and tumor diagnosis. Critical issues are addressed in a straightforward manner so those with no technical background and university students can benefit from the information. Furthermore, many novel concepts in nanomaterials are explained in light of current theories. An important aspect of the book lies on its wide coverage in practical biomedical applications. Not only are the cutting-edge technologies in modern medicine introduced, but also unique materials applications in many clinical areas. Contents:Up-Conversion Nanoparticles for Early Cancer Diagnosis (Liang Cheng, Bingbo Zhang and Zhuang Liu)Redox-Sensitive Polymeric Nanoparticles for Intracellular Drug Delivery (Huiyun Wen, Yongyong Li and Xin Zhao)Design of Biocompatible PEIs as Artificial Gene Delivery Vectors (Ting Shi, Chao Lin and Peng Zhao)Magnetic Fe3O4 Nanoparticles for Cancer Photothermal Therapy (Maoquan Chu)Nanomaterial-Based Sensors for Environmental Monitoring (Jinhu Yang)Janus Nanostructures and Their Bio-Medical Applications (Yilong Wang and Feng Wang)Nanomaterial-Involved Optical Imaging/Spectroscopy Methods for Single-Molecule Detections in Biomedicine (Yao Qin)Surface Functionalized Carbon Nanotubes for Biomedical Applications (Bingdi Chen)Intracellular siRNA Delivery by Multifunctional Nanoparticles (Kun Lu, Lei Wang, Xiaohui Tan, Yao Chen, Changhui Wang and Lifeng Qi)Chemical and Biological Sensors Based on Nanowire Transistors (Xiaohan Wu and Jia Huang) Readership: Undergraduate or graduate students, and researchers in nanomaterials, biochemistry, biomedical engineering. Key Features:It is closely clinically oriented in medical diagnosis and treatmentIt is comprehensive in both nanomaterials and biomedical applicationsIt includes many novel concepts in nanotechnology and up to dateKeywords:Nanomedicine;Nanobiomedicine;Nanobiotechnology;Nanomaterials;Bio-Probes;Medical Imaging;Drug delivery;Tumor Diagnosis

Author : Prashant Kesharwani
Publisher : Academic Press
ISBN 13 : 0128173319
Total Pages : 434 pages
Book Rating : 4.12/5 ( download)

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Download or read book Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics written by Prashant Kesharwani and published by Academic Press. This book was released on 2019-06-25 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric Nanoparticles as Promising Tool for Anti-cancer Therapeutics provides an understanding of polymeric compounds and their use in cancer therapies. The book begins by giving an overview of the current status, future challenges and potential utilization of polymeric nanoparticles. It then covers specific polymeric nanoparticles through contributions from world-renowned experts and researchers. Chapters examine specific polymeric nanoparticles, their development as potential targeted delivery systems, and cancer characteristics that can be targeted for therapy development. The book synthesizes current research trends in the field, thus enhancing existing knowledge of nanomedicine, drug delivery and therapeutic intervention strategies in human cancers. Users will find this to be an ideal reference for research scientists and those in the pharmaceutical and medical fields who are working to develop novel cancer therapies using nanoparticle-based delivery systems. Explores the development of polymeric nanoparticle systems for the purpose of cancer therapy Presents thoroughly analyzed data and results regarding the usage of polymeric nanoparticles-based platforms for the diagnosis and treatment of cancer Highlights various cancer characteristics that can be targeted for therapeutic development using polymeric nanoparticles

Author : Sabyasachi Maiti
Publisher : BoD – Books on Demand
ISBN 13 : 9535131214
Total Pages : 186 pages
Book Rating : 4.12/5 ( download)

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Download or read book Advanced Technology for Delivering Therapeutics written by Sabyasachi Maiti and published by BoD – Books on Demand. This book was released on 2017-05-11 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of any novel drug delivery system is to provide therapeutic benefits to the patients by increasing duration of drug action, reducing dosing frequency, and controlling drug release rate at the target site, thereby reducing unwanted side effects. Advanced Technology for Delivering Therapeutics is a reference book that covers recent developments in the field of drug delivery science and technology. The purpose of this book is to bring together descriptions of some selective technologies including new and promising nanotechnology currently being investigated for drug delivery applications. This book is a useful source of information for graduate and post-graduate students of pharmacy and biomedical science; pharmaceutical

Author : Sougata Jana
Publisher : John Wiley & Sons
ISBN 13 : 3527349049
Total Pages : 1063 pages
Book Rating : 4.43/5 ( download)

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Download or read book Nanoengineering of Biomaterials written by Sougata Jana and published by John Wiley & Sons. This book was released on 2022-04-18 with total page 1063 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for researchers in materials chemistry and related disciplines. It uses a functions-directed approach to using organic and inorganic source compounds that translate into biological systems as scaffolds, micelles, dendrimers, and other delivery systems. Nanoengineering of Biomaterials offers readers up-to-date chemistry and material science insights that are readily transferrable to biomedical systems. The book also includes: Thorough introductions to alginate nanoparticle delivery of therapeutics and chitosan-based nanomaterials in biological applications Comprehensive explorations of nanostructured carrageenan as a drug carrier, gellan gum nanoparticles in drug delivery, and guar-gum nanoparticles in the delivery of bioactive molecules Practical discussions of protein-based nanoparticles for drug delivery, solid lipid nanoparticles as drug carriers, and pH-responsive nanoparticles in therapy In-depth examinations of stimuli-responsive nano carriers in drug targeting Perfect for pharmaceutical chemists, materials scientists, polymer chemists, life scientists, and medicinal chemists, Nanoengineering of Biomaterials: Drug Delivery and Biomedical Applications is also an indispensable resource for biologists and bioengineers seeking a one-stop reference on the transferability of materials chemistry and nanotechnology to biomedicine.