Pathology Of The Fischer Rat

Author : Gary A. Boorman
Publisher : San Diego : Academic Press
ISBN 13 : 9780121156404
Total Pages : 580 pages
Book Rating : 4.00/5 ( download)

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Download or read book Pathology of the Fischer Rat written by Gary A. Boorman and published by San Diego : Academic Press. This book was released on 1990 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in rodents of the toxicity and carcinogenicity of drugs, agricultural agents (e.g., pesticides and herbicides), environmental pollutants, industrial agents (e.g., solvents and intermediates), and other chemicals are the cornerstone of human safety evaluations in the development, use, and/or regulation of these agents. Those who perform the pathological evaluations from these studies need standard diagnostic criteria and pathology terminology. Pathology of the Fischer Rat is a comprehensive pathology reference text on the Fischer 344 rat, the strain widely used for safety evaluations and almost exclusively by the National Toxicology Program.****Every chapter follows the same format of introduction; embryology; normal anatomy, histology, and physiology; and congenital, degenerative, inflammatory and vascular, hyperplastic and neoplastic, miscellaneous, and toxicological lesions. The spectrum of spontaneous and treatment-related, neoplastic and nonneoplastic lesions found in each tissue is described and photographed.****The text is useful not only to pathologists but also to investigators from a variety of disciplines who use the rat as an animal model. It will also prove valuable to toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to promulgation of meaningful regulations.

Author : Sherman F. Stinson
Publisher : CRC Press
ISBN 13 : 9780849354625
Total Pages : 564 pages
Book Rating : 4.25/5 ( download)

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Download or read book Atlas of Tumor Pathology of the Fischer Rat written by Sherman F. Stinson and published by CRC Press. This book was released on 1990-01-17 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive resource of the most recent findings on the pathogenesis and pathology in the Fischer rat. Each chapter, adequately illustrated with light and electron photomicrographs, deals with a specific organ system. It includes a summary of the spontaneous neoplasms found in over 5,000 untreated control animals as well as a detailed, step by step necropsy procedure completely illustrated by photographs. It refers to a listing of common and rare tumors associated with the administration of various environmental agents obtained from over 200 carcinogenesis bioassays of the National Cancer Institute and National Toxicology Program. This work also reveals detailed information on spontaneous occurrence and the induction of neoplasms. Scientists involved in the evaluation of toxicological and carcinogenesis bioassays and investigators conducting basic and applied carcinogenesis research will find this atlas indispensable.

Author : Stinson SF Ed
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.14/5 ( download)

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Download or read book Atlas of Tumor Pathology of the Fischer Rat written by Stinson SF Ed and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Andrew W. Suttie
Publisher : Academic Press
ISBN 13 : 0123914892
Total Pages : 748 pages
Book Rating : 4.97/5 ( download)

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Download or read book Boorman's Pathology of the Rat written by Andrew W. Suttie and published by Academic Press. This book was released on 2017-12-18 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. Contains full, four color photographs from the NTP archive and database and coverage of all rat strains Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes Includes comprehensive and detailed background incidence data Presents detailed descriptive content regarding changes in rat models during research

Author : Mark A. Suckow
Publisher : Elsevier
ISBN 13 : 0080454321
Total Pages : 928 pages
Book Rating : 4.20/5 ( download)

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Download or read book The Laboratory Rat written by Mark A. Suckow and published by Elsevier. This book was released on 2005-12-20 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Laboratory Rat, Second Edition features updated information on a variety of topics including: rat genetics and genomics, both spontaneous and induced disease; state-of-the-art technology for housing and husbandry; occupational health, and experimental models. A premier source of information on the laboratory rat that will be of interest to veterinary and medical students, senior graduate, graduate students, post-docs and researchers who utilize animals in biomedical research. At least 50% new information than first edition Includes topics on rat genetics and genomics, occupational health, and experimental models The premier source of information on the laboratory rat

Author : George J. Krinke
Publisher : Elsevier
ISBN 13 : 9780080533469
Total Pages : 756 pages
Book Rating : 4.69/5 ( download)

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Download or read book The Laboratory Rat written by George J. Krinke and published by Elsevier. This book was released on 2000-06-20 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference series will provide all researchers using laboratory animals with comprehensive practical information on the various species. Each title in the series is devoted to a particular species, and draws together all available data in a "one-stop", easily accessible source. Each has similar format, with sections on the strains available, their husbandry, and special diets. Also included are sections on gross anatomy, endocrinology, and reproduction, followed by more detailed sections on neuroanatomy, vasculature, cell biology, and histology of particular organs and structures, and a section on molecular biology. High quality illustrations are included throughout and a color plate section is provided. A glossary, list of equipment suppliers, and "Quick Reference Section" are added features. The "Quick Reference Section" brings together all tables from the text, allowing readers to find data swiftly. The first volume in The Handbook of Experimental Animals Series, The Laboratory Rat, provides researchers in academia and industry using laboratory animals with comprehensive, practical information on the species. The Laboratory Rat has been divided into eight sections dealing with: * Strains and their selection for research * Housing and maintenance * Pathogens and diseases * Breeding and reproduction * Anatomy * Physiology * Procedures, including experimental surgery * Emerging techniques, including genetic engineering and molecular technology Key Features * Provides a valuable, comprehensive reference source for anybody working with the laboratory rat * Formatted in a two-color, user-friendly layout * Includes high-quality illustrations throughout as well as a color plate section * Glossary * Tables in the text are also arranged into one Quick Reference Section for ease of access to the data * Appendix of equipment suppliers

Author : Lynn C. Anderson
Publisher : Elsevier
ISBN 13 : 012416613X
Total Pages : 1727 pages
Book Rating : 4.34/5 ( download)

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Download or read book Laboratory Animal Medicine written by Lynn C. Anderson and published by Elsevier. This book was released on 2015-07-04 with total page 1727 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine’s acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields. Users will find gold-standard guidance on the study of laboratory animal science, as well as valuable information that applies across all of the biological and biomedical sciences that work with animals. Organized by species for in-depth understanding of biology, health, and best care of animals Features the inclusion of chinchillas, quail, and zebra finches as animal models Offers guidance on program and employee management Covers regulations, policies, and laws for laboratory animal management worldwide

Author : National Institutes of Health (U.S.).
Publisher :
ISBN 13 :
Total Pages : 564 pages
Book Rating : 4.76/5 ( download)

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Download or read book Published Scientific Papers of the National Institutes of Health written by National Institutes of Health (U.S.). and published by . This book was released on 1990 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the broad outline of NIH organizational structure, theprofessional staff, and their scientific and technical publications covering work done at NIH.

Author : Elizabeth Fiona McInnes
Publisher : Elsevier Health Sciences
ISBN 13 : 0702049247
Total Pages : 256 pages
Book Rating : 4.48/5 ( download)

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Download or read book Background Lesions in Laboratory Animals E-Book written by Elizabeth Fiona McInnes and published by Elsevier Health Sciences. This book was released on 2011-10-24 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals a chapter on common artifacts that may be observed in histological glass slides extensive references to each lesion described aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies

Author : Pritam S. Sahota
Publisher : CRC Press
ISBN 13 : 0429997450
Total Pages : 1897 pages
Book Rating : 4.57/5 ( download)

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Download or read book Toxicologic Pathology written by Pritam S. Sahota and published by CRC Press. This book was released on 2018-08-14 with total page 1897 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.