Pathogenesis Of Systemic Lupus Erythematosus

Author : Alberta Hoi
Publisher : Springer Nature
ISBN 13 : 3030851613
Total Pages : 192 pages
Book Rating : 4.13/5 ( download)

DOWNLOAD NOW!

Download or read book Pathogenesis of Systemic Lupus Erythematosus written by Alberta Hoi and published by Springer Nature. This book was released on 2021-11-15 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.

Author : Peter H. Schur
Publisher : Springer Science & Business Media
ISBN 13 : 1461411890
Total Pages : 266 pages
Book Rating : 4.95/5 ( download)

DOWNLOAD NOW!

Download or read book Lupus Erythematosus written by Peter H. Schur and published by Springer Science & Business Media. This book was released on 2012-07-06 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Often considered the prototypic autoimmune disease, Lupus is characterized by protean manifestations and affects a wide range of organ systems. Despite widespread availability of anti nuclear antibody testing and other technological diagnostic advances, the diagnosis of lupus can be elusive, difficult, and inexact. Treatment of the disease can also be challenging. Advances in immunology and biotechnology have led to a burgeoning world of new therapies in development that offer patients the real possibility of new therapies and physicians and scientists novel insights into the pathogenesis of this complicated immunological disease. Lupus Erythematosus: Clinical Evaluation and Treatment summarizes the clinical aspects of lupus facing the general clinician in the 21st century. In this invaluable, practical book, the reader will find introductory chapters regarding general diagnostic and treatment principles, followed by chapters addressing the lupus-specific organ manifestations. Special topics regarding pregnancy and comorbidities are also presented. Written by highly experienced physicians with special expertise in lupus, Lupus Erythematosus: Clinical Evaluation and Treatment is an indispensable reference for the common and not so common problems affecting patients with lupus.

Author : René Mauricio Barría
Publisher :
ISBN 13 : 1789236940
Total Pages : 73 pages
Book Rating : 4.41/5 ( download)

DOWNLOAD NOW!

Download or read book Cohort Studies in Health Sciences written by René Mauricio Barría and published by . This book was released on 2018-09 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Caroline Gordon
Publisher : Oxford University Press
ISBN 13 : 0198739184
Total Pages : 161 pages
Book Rating : 4.80/5 ( download)

DOWNLOAD NOW!

Download or read book Systemic Lupus Erythematosus written by Caroline Gordon and published by Oxford University Press. This book was released on 2016 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus (often abbreviated to SLE or lupus) is a systemic autoimmune disease that can affect any part of the body, causing the immune system to attack the body's cells and tissue, and resulting in inflammation and tissue damage. This new addition to the Oxford Rheumatology Library series provides a practical approach to the assessment and management of patients with this complex, multisystem autoimmune disease to improve the diagnosis and treatment of the disease and its complications. It provides comprehensive but easy to assimilate reading for consultant rheumatologists, dermatologists, nephrologists, obstetricians and other specialists and their trainees, interested GPs, specialist nurses, and clinical trial teams both in hospitals and contract research organizations.

Author : Paul Eggleton
Publisher : Humana
ISBN 13 : 9781493952625
Total Pages : 0 pages
Book Rating : 4.25/5 ( download)

DOWNLOAD NOW!

Download or read book Systemic Lupus Erythematosus written by Paul Eggleton and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus: Methods and Protocols describe a number of genetic, biochemical and immunological techniques. These techniques provide an advancing understanding of the pathology, breakdown of the immune system and therapeutic challenges of SLE in both humans and animal models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Systemic Lupus Erythematosus: Methods and Protocols appeal to biomedical and clinical scientists in a number of pathology disciplines at the doctoral and post-doctoral level.

Author : John B. Imboden
Publisher : McGraw-Hill/Appleton & Lange
ISBN 13 :
Total Pages : 532 pages
Book Rating : 4.14/5 ( download)

DOWNLOAD NOW!

Download or read book Current Rheumatology Diagnosis & Treatment written by John B. Imboden and published by McGraw-Hill/Appleton & Lange. This book was released on 2004 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: An ideal quick reference for primary care providers, specialists, and trainees, this accessible resource offers up-to-date assessment and management solutions for the entire range of rheumatologic diseases.

Author : Kutty Selva Nandakumar
Publisher : Frontiers Media SA
ISBN 13 : 2832511996
Total Pages : 264 pages
Book Rating : 4.92/5 ( download)

DOWNLOAD NOW!

Download or read book Systemic Lupus Erythematosus - Predisposition Factors, Pathogenesis, Diagnosis, Treatment and Disease Models written by Kutty Selva Nandakumar and published by Frontiers Media SA. This book was released on 2023-01-30 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Qingjun Pan
Publisher : Frontiers Media SA
ISBN 13 : 2889767027
Total Pages : 126 pages
Book Rating : 4.21/5 ( download)

DOWNLOAD NOW!

Download or read book Th2-Associated Immunity in The Pathogenesis of Systemic Lupus Erythematosus and Rheumatoid Arthritis written by Qingjun Pan and published by Frontiers Media SA. This book was released on 2022-08-04 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : George Tsokos
Publisher : Elsevier Health Sciences
ISBN 13 : 0323070876
Total Pages : 607 pages
Book Rating : 4.74/5 ( download)

DOWNLOAD NOW!

Download or read book Systemic Lupus Erythematosus E-Book written by George Tsokos and published by Elsevier Health Sciences. This book was released on 2007-02-23 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find ‘one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.

Author : Jasper Meyer
Publisher : American Medical Publishers
ISBN 13 : 9781639272136
Total Pages : 228 pages
Book Rating : 4.35/5 ( download)

DOWNLOAD NOW!

Download or read book Systemic Lupus Erythematosus: Pathogenesis and Treatment written by Jasper Meyer and published by American Medical Publishers. This book was released on 2021-11-16 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus (SLE) is a medical condition whereby the body's natural defense system targets the healthy tissues of the body. SLE is caused by a defect of the immune system that may arise due to a genetic susceptibility coupled with an environmental trigger. Vitamin D deficiency is another factor associated with lupus. Genetic studies show that SLE is an oligogenic trait with multiple genes contributing to it. The immune response once triggered produces antibodies against itself, and specifically the proteins in the cell nucleus. Since SLE involves a number of different organ systems and exhibit a multitude of symptoms, its treatment is ideally based on its severity. The treatment of SLE is aimed at preventing flares, reducing the severity of flares and their duration when they occur. Treatment can comprise of anti-malarial drugs, immunosuppressive drugs, analgesics and intravenous immunoglobulins. This book contains some path-breaking studies in systemic lupus erythematosus. Also included in this book is a detailed explanation of the pathogenesis and treatment of systemic lupus erythematosus. The topics covered herein offer the readers new insights in this condition.