Organic Synthesis With Enzymes In Non Aqueous Media

Author : Giacomo Carrea
Publisher : John Wiley & Sons
ISBN 13 : 3527621733
Total Pages : 328 pages
Book Rating : 4.36/5 ( download)

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Download or read book Organic Synthesis with Enzymes in Non-Aqueous Media written by Giacomo Carrea and published by John Wiley & Sons. This book was released on 2008-04-09 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.

Author : Evgeny N. Vulfson
Publisher : Springer Science & Business Media
ISBN 13 : 1592591124
Total Pages : 677 pages
Book Rating : 4.21/5 ( download)

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Download or read book Enzymes in Nonaqueous Solvents written by Evgeny N. Vulfson and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymatic catalysis has gained considerable attention in recent years as an efficient tool in the preparation of natural products, pharmaceuticals, fine chemicals, and food ingredients. The high selectivity and mild reaction con- tions associated with enzymatic transformations have made this approach an attractive alternative in the synthesis of complex bioactive compounds, which are often difficult to obtain by standard chemical routes. However, the maj- ity of organic compounds are not very soluble in water, which was traditi- ally perceived as the only suitable reaction medium for the application of biocatalysts. The realization that most enzymes can function perfectly well under nearly anhydrous conditions and, in addition, display a number of useful properties, e. g. , highly enhanced stability and different selectivity, has d- matically widened the scope of their application to the organic synthesis. Another great attraction of using organic solvents rather than water as a reaction solvent is the ability to perform synthetic transformations with re- tively inexpensive hydrolytic enzymes. It is worth reminding the reader that in vivo, the synthetic and hydrolytic pathways are catalyzed by different enzymes. However, elimination of water from the reaction mixture enables the “reversal” of hydrolytic enzymes and thus avoids the use of the expensive cofactors or activated substrates that are required for their synthetic count- parts.

Author : Munishwar N. Gupta
Publisher : Birkhäuser
ISBN 13 : 3034884729
Total Pages : 229 pages
Book Rating : 4.23/5 ( download)

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Download or read book Methods in Non-Aqueous Enzymology written by Munishwar N. Gupta and published by Birkhäuser. This book was released on 2013-12-01 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extending the range of enzymatic catalysis by using non-aqueous media has now developed into a powerful approach in biochemistry and biotechnology. One peculiar feature which distinguishes it from the conventional enzymology (carried out in aqueous buffers) is that the awareness of different parameters that control and influence the behaviour of enzymes in such environments has emerged rather slowly. Science is about being able to repeat what somebody else has done. Absence of knowledge about such well-defined parameters/fac tors has sometimes made some workers rather cautious and diffident about using this approach in their laboratories. But for this, non-aqueous enzymol ogy would be more widely practised. It is these thoughts that made me feel that the availability of some well-defined protocols for various applications invol ving enzymes in non-aqueous environments would further catalyze the growth of this area. Hence this book, in which each chapter has some protocols in a specific area. The protocols are preceded by brief background material. The early chapters, which are of general importance, concern control of water ac tivity and stabilization via immobilization. Some subsequent chapters provide the protocols for transformations involving lipids and carbohydrates, peptide synthesis, and preparation of chiral compounds. The disproportionate focus on lipases is not a coincidence; this class of enzymes has been used more often than others in non-aqueous enzymology.

Author : A. Koskinen
Publisher : Springer Science & Business Media
ISBN 13 : 9401106118
Total Pages : 327 pages
Book Rating : 4.15/5 ( download)

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Download or read book Enzymatic Reactions in Organic Media written by A. Koskinen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: The outlook of organic synthesis has changed many times during its tractable history. The initial focus on the synthesis of substances typical of living matter, exemplified by the first examples of organic chemistry through the synthesis of urea from inorganic substances by Liebig, was accepted as the birth of organic chemistry, and thus also of organic synthesis. Although the early developments in organic synthesis closely followed the pursuit of molecules typical in nature, towards the end of the 19th century, societal pressures placed higher demands on chemical methods appropriate for the emerging age of industrialization. This led to vast amounts of information being generated through the discovery of synthetic reactions, spectroscopic techniques and reaction mechanisms. The basic organic functional group transformations were discovered and improved during the early part of this century. Reaction mechanisms were elucidated at a growing pace, and extremely powerful spectroscopic tools, such as infrared, nuclear magnetic resonance and mass spectrometry were introduced as everyday tools for a practising organic chemist. By the 1950s, many practitioners were ready to agree that almost every molecule could be syn thesized. Some difficult stereochemical problems were exceptions; for example Woodward concluded that erythromycin was a "hopelessly complex target". This frustration led to a hectic phase of development of new and increasingly more ingenious protecting group strategies and functional group transformations, and also saw the emergence of asymmetric synthesis.

Author : Gonzalo de Gonzalo
Publisher : John Wiley & Sons
ISBN 13 : 352734683X
Total Pages : 54 pages
Book Rating : 4.37/5 ( download)

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Download or read book Biocatalysis for Practitioners written by Gonzalo de Gonzalo and published by John Wiley & Sons. This book was released on 2021-07-19 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.

Author : C.H. Wong
Publisher : Elsevier
ISBN 13 : 0080505821
Total Pages : 389 pages
Book Rating : 4.24/5 ( download)

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Download or read book Enzymes in Synthetic Organic Chemistry written by C.H. Wong and published by Elsevier. This book was released on 2013-10-22 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the most recent development of enzymatic organic synthesis, with particular focus on the use of isolated enzymes. It is organized into one introductory chapter dealing with the characteristics of enzymes as catalysts, and five chapters dealing with different types of chemical transformations. Methods for enzyme immobilization and stabilizaton, the use of enzymes in extreme environments, and the alteration of enzyme properties by chemical modification and site-directed mutagenesis for synthetic purposes are covered.

Author : Harvey W. Blanch
Publisher : CRC Press
ISBN 13 : 9780824785338
Total Pages : 246 pages
Book Rating : 4.39/5 ( download)

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Download or read book Applied Biocatalysis written by Harvey W. Blanch and published by CRC Press. This book was released on 1991-06-24 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Karlheinz Drauz
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 380 pages
Book Rating : 4.45/5 ( download)

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Download or read book Enzyme Catalysis in Organic Synthesis written by Karlheinz Drauz and published by Wiley-VCH. This book was released on 2002-07-26 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic synthesis with enzymes - the only way This comprehensive set gives reliable answers to all questions on enzyme catalysis - from searching for suitable catalytic systems via choosing the optimal reaction conditions to implementing modern synthesis strategies. The long-awaited new edition has been greatly expanded to include new topics and to reflect the latest research, yet retains the clear and practice-oriented presentation found in the first edition. More than a mere data collection, the three volumes provide synthetic chemists with easy access to all the first-hand information necessary for successfully using enzymes: - the latest synthesis methods - example applications arranged according to reaction type - a table of all the important, commercially available enzymes - comprehensive registers for targeted searching according to enzyme, compound, or reaction - current references to the literature In short, an indispensable reference that should be on the shelf of every modern synthesis laboratory.

Author : Uwe Theo Bornscheuer
Publisher : John Wiley & Sons
ISBN 13 : 3527607129
Total Pages : 368 pages
Book Rating : 4.29/5 ( download)

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Download or read book Hydrolases in Organic Synthesis written by Uwe Theo Bornscheuer and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: From reviews to the first edtion: "Bornscheuer and Kazlauskas have set out, and succeeded, in producing a definitive manual on hydrolytic enzymes (especially lipases, esterases, and proteases) for organic chemists. This is quite simply the best book of its type and can be unreservedly recommended to organic chemists who have an interest in using hydrolytic enzymes in synthesis." (Nicholas J. Turner, University of Edinburgh) "The book is an indispensable source of information on the use of hydrolases in organic synthesis. The subject matter is very well set out, and the chapters are clearly written and presented from a critical viewpoint. Bornscheuer and Kazlauskas have succeeded admirably in describing the capabilities and limitations of the use of hydrolytic enzymes and in critically evaluating them. No library should be without the book." (Fritz Theil, WITEGA Angewandte Werkstoff-Forschung GmbH, Berlin) The second edition of this extremely successful and well-proven book presents recent developments in the use of hydrolases for organic synthesis, reflecting in particular the enormous progress made in enzyme discovery and optimization with a new chapter on "Protein Sources and Optimization of Biocatalyst Performance". The renowned authors survey the stereoselective reactions of hydrolases, especially lipases, esterases and proteases, giving researchers an overview of what has worked in the past so that they can judge how to solve their own synthetic problems. In total, the book contains over one thousand chemical structures, rounded off by some 1,800 invaluable references.

Author : Maria Alice Z. Coelho
Publisher : Royal Society of Chemistry
ISBN 13 : 1849738165
Total Pages : 434 pages
Book Rating : 4.63/5 ( download)

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Download or read book White Biotechnology for Sustainable Chemistry written by Maria Alice Z. Coelho and published by Royal Society of Chemistry. This book was released on 2016 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: