Oral Lipid Based Formulations

Author : David J. Hauss
Publisher : CRC Press
ISBN 13 : 1420017268
Total Pages : 370 pages
Book Rating : 4.67/5 ( download)

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Download or read book Oral Lipid-Based Formulations written by David J. Hauss and published by CRC Press. This book was released on 2007-06-08 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem

Author : David J. Hauss
Publisher : CRC Press
ISBN 13 : 9780824729455
Total Pages : 0 pages
Book Rating : 4.55/5 ( download)

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Download or read book Oral Lipid-Based Formulations written by David J. Hauss and published by CRC Press. This book was released on 2007-06-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem of major significance, the pharmaceutical industry has been slow to apply and further develop this technology. This title provides a comprehensive summary of the theoretical and practical aspects of oral lipid-based formulations for use in industry, and provides further insights into a developing technology expected to assume increasing prominence in years to come.

Author : Nikoletta Fotaki
Publisher : John Wiley & Sons
ISBN 13 : 1118675835
Total Pages : 314 pages
Book Rating : 4.30/5 ( download)

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Download or read book In Vitro Drug Release Testing of Special Dosage Forms written by Nikoletta Fotaki and published by John Wiley & Sons. This book was released on 2019-10-11 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guides readers on the proper use of in vitro drug release methodologies in order to evaluate the performance of special dosage forms In the last decade, the application of drug release testing has widened to a variety of novel/special dosage forms. In order to predict the in vivo behavior of such dosage forms, the design and development of the in vitro test methods need to take into account various aspects, including the dosage form design and the conditions at the site of application and the site of drug release. This unique book is the first to cover the field of in vitro release testing of special dosage forms in one volume. Featuring contributions from an international team of experts, it presents the state of the art of the use of in vitro drug release methodologies for assessing special dosage forms’ performances and describes the different techniques required for each one. In Vitro Drug Release Testing of Special Dosage Forms covers the in vitro release testing of: lipid based oral formulations; chewable oral drug products; injectables; drug eluting stents; inhalation products; transdermal formulations; topical formulations; vaginal and rectal delivery systems and ophthalmics. The book concludes with a look at regulatory aspects. Covers both oral and non-oral dosage forms Describes current regulatory conditions for in vitro drug release testing Features contributions from well respected global experts in dissolution testing In Vitro Drug Release Testing of Special Dosage Forms will find a place on the bookshelves of anyone working with special dosage forms, dissolution testing, drug formulation and delivery, pharmaceutics, and regulatory affairs.

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
ISBN 13 : 012813688X
Total Pages : 674 pages
Book Rating : 4.81/5 ( download)

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Download or read book Lipid Nanocarriers for Drug Targeting written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2018-04-16 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid Nanocarriers for Drug Targeting presents recent advances in the area of lipid nanocarriers. The book focuses on cationic lipid nanocarriers, solid lipid nanocarriers, liposomes, thermosensitive vesicles, and cubosomes, with applications in phototherapy, cosmetic and others. As the first book related to lipid nanocarriers and their direct implication in pharmaceutical nanotechnology, this important reference resource is ideal for biomaterials scientists and those working in the medical and pharmaceutical industries that want to learn more on how lipids can be used to create more effective drug delivery systems. Highlights the most commonly used types of lipid nanocarriers and explains how they are applied in pharmacy Shows how lipid nanocarriers are used in different types of treatment, including oral medicine, skin repair and cancer treatment Assesses the pros and cons of using different lipid nanocarriers for different therapies

Author : Vasant V. Ranade
Publisher : CRC Press
ISBN 13 : 1420040146
Total Pages : 464 pages
Book Rating : 4.42/5 ( download)

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Download or read book Drug Delivery Systems written by Vasant V. Ranade and published by CRC Press. This book was released on 2003-08-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug delivery technologies represent a vast and vital area of Research and Development. The demand for innovative drug delivery systems continues to grow, and this growth continues to drive new developments. Building on the foundation provided by the first edition, Drug Delivery Systems, Second Edition covers the latest developments in both

Author : Linda Joy Solomon
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.97/5 ( download)

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Download or read book Lipid-based Formulations for Oral Delivery of Poorly Water-soluble Drugs written by Linda Joy Solomon and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Yogeshwar Bachhav
Publisher : John Wiley & Sons
ISBN 13 : 3527343962
Total Pages : 470 pages
Book Rating : 4.66/5 ( download)

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Download or read book Innovative Dosage Forms written by Yogeshwar Bachhav and published by John Wiley & Sons. This book was released on 2019-12-04 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.

Author : Vivek Dave
Publisher : John Wiley & Sons
ISBN 13 : 1119711681
Total Pages : 467 pages
Book Rating : 4.81/5 ( download)

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Download or read book Nanopharmaceutical Advanced Delivery Systems written by Vivek Dave and published by John Wiley & Sons. This book was released on 2020-12-29 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.

Author : William N. Charman
Publisher : CRC Press
ISBN 13 : 9780849363948
Total Pages : 348 pages
Book Rating : 4.42/5 ( download)

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Download or read book Lymphatic Transport of Drugs written by William N. Charman and published by CRC Press. This book was released on 1992-04-22 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lymphatic Transport of Drugs provides a thorough review of the determinants that affect the uptake and delivery of drugs and xenobiotics to the lymphatics. Factors affecting the transport and delivery of lipophilic drugs through the lymph after oral administration, lymphatic transport of polar drugs and macromolecules after gastrointestinal dosing, transport of drugs into the lymph after parenteral administration, and particulate drug delivery systems are among the topics examined in this volume. Lymphatic Transport of Drugs is primarily intended for pharmaceutical scientists who are attempting to alter the delivery of current therapeutic agents through formulation of prodrugs, as well as for researchers designing new drugs for lymph delivery.

Author : Kazi Mohsin
Publisher :
ISBN 13 :
Total Pages : 558 pages
Book Rating : 4.22/5 ( download)

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Download or read book Design of Lipid-based Formulations for Oral Administration of Poorly Water-soluble Drugs written by Kazi Mohsin and published by . This book was released on 2009 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: The work presented in this thesis has provided additional information regarding the utilisation of lipid-based self-emulsifying formulations for lipophilic drugs, making use of fenofibrate as a model. Specifically the work focused on lipid-based formulation in the context of the emerging "Lipid Formulation Classification System" (LFCS) which has been previously proposed as a new means of classifying lipid-based formulations. This is the first study to address lipid formulations using a small group of related excipients to cover a wide range of lipid formulations. The roles of the lipid phase, the effect of the ratio of lipid to surfactant and the presence of cosolvent on the performance of formulations were investigated. A series of phase diagrams were constructed to examine the phase behaviour during dispersion of anhydrous formulations. Type II, IIIA, IIIB and IV (SEDDS & SMEDDS) were investigated using medium chain glycerides (MCGs), polysorbates and propylene glycol (PG) as excipients. Equilibrium solubilities of the drug were determined in mixtures equivalent to diluted formulations to examine the likelihood of precipitation on dispersion. These data were compared with drug precipitation data obtained in dynamic dispersion experiments. Precipitation was measured over time after 1 in 100 dilutions of formulations in aqueous media. Aqueous dispersion of Type II lipid formulations resulted in turbid emulsions, followed subsequently by very slow precipitation of fraction of the drug dose. Type IIIA formulations, which carried less drug in solution at equilibrium, nevertheless typically maintained drugs in a metastable state for several hours or even days. These studies suggested that Type II and Type IIIA formulations were the most appropriate for fenofibrate. Diluted formulations were also subjected to in vitro digestion to predict the fate of the drug in the gastrointestinal (GI) tract after exposure of the formulation to pancreataic enzymes and bile. In vitro digestion experiments were carried out using a pH-stat maintained pH 7.5 for 30 minutes using intestinal fluids simulating the fed and fasted states (FeSSIF and FaSSIF). The digestion rate was higher in Type II & IIIA systems. Formulations with higher content of hydrophillic materials (Type IIIB or Type IV) resulted in more rapid precipitation, and extensive precipitation of drug from Type IV formulations took place rapidly. The high concentration of surfactant and or cosolvent lowered the rate of digestion but considerable precipitation occurred due to lack of solvent capacity of diluted formulations. Digestion experiments suggested that drug was in a supersaturated state which could be maintained in the presence of mixed bile salt micelles. The fate of fenofibrate is dependent on the choice of lipid formulation as exemplified by the LFCS. In particular the current study suggests that Type IIIB or Type IV formulation may be unsuitable for highly lipophilic drugs, but in vitro tests suggested that after digestion there was a considerable risk of precipitation from all formulations.