Optical Microendoscopy For Imaging Cells Lying Deep Within Live Tissue

Author : Robert Juson Barretto
Publisher : Stanford University
ISBN 13 :
Total Pages : 149 pages
Book Rating : 4.19/5 ( download)

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Download or read book Optical Microendoscopy for Imaging Cells Lying Deep Within Live Tissue written by Robert Juson Barretto and published by Stanford University. This book was released on 2010 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical microendoscopy is an emerging modality for imaging in live subjects. Using gradient refractive index (GRIN) microlenses, microendoscopy enables subcellular-resolution imaging in deep tissues that are inaccessible by traditional imaging techniques. We present a platform of methods and technologies that build upon GRIN microendoscopy: 1) miniaturized microscopes for imaging in awake, behaving animals, 2) methods for imaging contractile dynamics in the muscles of animal and human subjects, 3) chronic brain preparations that allow for longitudinal examinations of subcellular neuronal features and disease progression, and 4) novel microendoscope probes whose imaging capabilities approach that of standard water-immersion microscope objectives. When combined with the broad sets of available fluorescent reporters, and minimally invasive surgical preparations, the work described in this dissertation enables sophisticated experimental designs for probing how cellular char- acteristics may underlie or explain behavior, in models of both healthy and diseased states.

Author : Robert Juson Barretto
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.40/5 ( download)

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Download or read book Optical Microendoscopy for Imaging Cells Lying Deep Within Live Tissue written by Robert Juson Barretto and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical microendoscopy is an emerging modality for imaging in live subjects. Using gradient refractive index (GRIN) microlenses, microendoscopy enables subcellular-resolution imaging in deep tissues that are inaccessible by traditional imaging techniques. We present a platform of methods and technologies that build upon GRIN microendoscopy: 1) miniaturized microscopes for imaging in awake, behaving animals, 2) methods for imaging contractile dynamics in the muscles of animal and human subjects, 3) chronic brain preparations that allow for longitudinal examinations of subcellular neuronal features and disease progression, and 4) novel microendoscope probes whose imaging capabilities approach that of standard water-immersion microscope objectives. When combined with the broad sets of available fluorescent reporters, and minimally invasive surgical preparations, the work described in this dissertation enables sophisticated experimental designs for probing how cellular char- acteristics may underlie or explain behavior, in models of both healthy and diseased states.

Author : Jin Zhang
Publisher : CRC Press
ISBN 13 : 1466510129
Total Pages : 511 pages
Book Rating : 4.28/5 ( download)

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Download or read book Optical Probes in Biology written by Jin Zhang and published by CRC Press. This book was released on 2016-04-19 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical probes, particularly the fluorescent varieties, enable researchers to observe cellular events in real time and with great spatial resolution. Optical Probes in Biology explores the diverse capabilities of these powerful and versatile tools and presents various approaches used to design, develop, and implement them. The book examines the use of optical probes to detect and track numerous molecular processes in living cells, including GTPase and kinase activities, membrane lipids, voltage, metal ions, metabolic signals, RNA, and histone modifications. It critically reviews the different probe designs and delves into the strategies for developing new fluorescent protein varieties with enhanced capabilities. It also covers sophisticated imaging techniques and equipment, such as intensity and lifetime-based fluorescence microscopy methods, used to visualize and track optical probes. In addition, the book goes beyond live-cell tracking to discuss the growing application of activity-based probes for performing pharmacological drug screening and probing molecular processes in living animals. It also discusses emerging techniques that are expanding optical probe-based approaches into new biological frontiers. With contributions from top international scientists, this book offers a thorough overview of the latest optical probes in cell biology and biochemistry. Both newcomers and established researchers will discover how to incorporate state-of-the-art optical probes and fluorescence imaging into their research.

Author : Jeffrey R. Capadona
Publisher : Frontiers Media SA
ISBN 13 : 2889638502
Total Pages : 378 pages
Book Rating : 4.05/5 ( download)

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Download or read book Bridging the Gap in Neuroelectronic Interfaces written by Jeffrey R. Capadona and published by Frontiers Media SA. This book was released on 2020-07-09 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Andre F. Carvalho
Publisher : Bentham Science Publishers
ISBN 13 : 1681084732
Total Pages : 416 pages
Book Rating : 4.32/5 ( download)

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Download or read book The Search for Antidepressants - An Integrative View of Drug Discovery written by Andre F. Carvalho and published by Bentham Science Publishers. This book was released on 2017-07-10 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major depressive disorder (MDD) is a prevalent, chronic, and recurring mental disorder. This disorder is a leading source of disability worldwide, and is associated with excess mortality rates. Currently approved antidepressants primarily enhance, or otherwise modulate monoaminergic neurotransmission, without curing the disease. Evidence indicates that only one third of patients with MDD achieve remission after treatment with a first-line antidepressant agent. Research in the past two decades has provided valuable insights into the pathophysiological understanding of MDD. However, there is an acknowledged ‘translational gap’ in the field, and few genuinely novel antidepressants have been approved for the treatment of MDD. The Search for Anti Depressants provides readers an in-depth picture of the main pathophysiological mechanisms responsible for the development of MDD in patients. Chapters in the volume focus on possible strategies to spur the discovery of novel antidepressants. This book is an indispensable reference for mental health care providers, students at both under-graduate and graduate levels, and neuroscientists interested in the neurobiology of MDD and recent advances towards the discovery of next generation antidepressants.

Author : Peter W. Kalivas
Publisher : MIT Press
ISBN 13 : 0262542374
Total Pages : 475 pages
Book Rating : 4.71/5 ( download)

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Download or read book Intrusive Thinking written by Peter W. Kalivas and published by MIT Press. This book was released on 2021-03-02 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: An exploration of the neurological and behavioral mechanisms and processes involved in intrusive thinking. On any given day, unintended, recurrent thoughts intrude on our thinking and affect our behavior in ways that can be adaptive. Such thoughts, however, become intrusive and problematic when they are unwanted, become compulsive, or lead to socially or medically unacceptable behavior. This volume explores what goes on in our brains to create thought intrusions, and how these instrusions lead to maladaptive behavior.

Author : João O. Malva
Publisher : Frontiers Media SA
ISBN 13 : 2889717259
Total Pages : 498 pages
Book Rating : 4.55/5 ( download)

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Download or read book Advanced Imaging Methods in Neuroscience written by João O. Malva and published by Frontiers Media SA. This book was released on 2022-01-11 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Nitish V. Thakor
Publisher : Springer Nature
ISBN 13 : 9811655405
Total Pages : 3686 pages
Book Rating : 4.01/5 ( download)

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Download or read book Handbook of Neuroengineering written by Nitish V. Thakor and published by Springer Nature. This book was released on 2023-02-02 with total page 3686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.​

Author : Qiang Yan
Publisher : BoD – Books on Demand
ISBN 13 : 178985069X
Total Pages : 106 pages
Book Rating : 4.97/5 ( download)

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Download or read book Advanced Endoscopy written by Qiang Yan and published by BoD – Books on Demand. This book was released on 2020-03-11 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the rapid development of modern medical technology, endoscopic technology has also achieved unprecedented development. Its fields cover examination, treatment, surgery, and even molecular imaging diagnosis. Endoscopy technology brings a minimally invasive diagnosis and treatment experience to patients. Invasive treatment and examination of digestive surgery has changed from large incisions to several Trocar holes, from surgery to endoscopic treatment, and from laparotomy to endoscopy or laparoscopy, which has changed the diagnosis treatment and management of digestive surgery, enhanced the recovery after surgery, and benefited the patients needing to undergo surgical procedures. It is for this reason that we plan to introduce the development of endoscopic and laparoscopic surgery in digestive surgery and enhanced rehabilitation medicine.

Author : Yoshiaki Toyama
Publisher : Springer Nature
ISBN 13 : 9811379084
Total Pages : 292 pages
Book Rating : 4.86/5 ( download)

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Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.