Nucleic Acid Probes In Diagnosis Of Human Genetic Diseases

Author : Ann M. Willey
Publisher : Wiley-Liss
ISBN 13 : 9780471500353
Total Pages : 294 pages
Book Rating : 4.56/5 ( download)

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Download or read book Nucleic Acid Probes in Diagnosis of Human Genetic Diseases written by Ann M. Willey and published by Wiley-Liss. This book was released on 1988-09-29 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews the basic terminology and techniques of nucleic acid probes, how such probes can be used in the detection and analysis of human genetic disorders, and the impact of this technology on public health care services and on affected individuals and their families. Addresses use of nucleic acid probes in prenatal and carrier detection of Duchenne muscular dystrophy, the cystic fibrosis region of chromosome 7, and the fragile X chromosome. Also discusses ethical issues raised by use of this technology, the role of regulatory agencies, and the establishment of a centralized DNA-based genetic reference laboratory.

Author : Ann M. Willey
Publisher : Alan R. Liss
ISBN 13 :
Total Pages : 304 pages
Book Rating : 4.45/5 ( download)

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Download or read book Nucleic Acid Probes in Diagnosis of Human Genetic Diseases written by Ann M. Willey and published by Alan R. Liss. This book was released on 1988 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Robert H. Symons
Publisher : CRC Press
ISBN 13 : 9780849349423
Total Pages : 246 pages
Book Rating : 4.27/5 ( download)

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Download or read book Nucleic Acid Probes written by Robert H. Symons and published by CRC Press. This book was released on 1989-03-31 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: With each chapter written by a distinguished expert in the biochemistry field, this comprehensive volume describes the preparation and use of a variety of radioactive and non-radioactive probes in situations ranging from research laboratories to routine diagnosis laboratories. The enzymatic and chemical techniques for labeling nucleic acid probes with radioisotopes and with non-radioactive ligands and haptens are discussed. Additionally, the associated methods for their detection, the use of these probes in the diagnosis of human and microbial pathogens, of plant viruses and viroids, and of human genetic disorders, as well as in the detection of nucleic acids in tissues and cells by in situ hybridization are presented.

Author : Volker A. Erdmann
Publisher : Springer
ISBN 13 : 3319173057
Total Pages : 353 pages
Book Rating : 4.54/5 ( download)

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Download or read book RNA and DNA Diagnostics written by Volker A. Erdmann and published by Springer. This book was released on 2015-06-10 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman’s famous statement “What I cannot create, I do not understand.”

Author : Attila Lorincz
Publisher : CRC Press
ISBN 13 : 1000713431
Total Pages : 491 pages
Book Rating : 4.35/5 ( download)

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Download or read book Nucleic Acid Testing for Human Disease written by Attila Lorincz and published by CRC Press. This book was released on 2016-04-19 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleic Acid Testing for Human Disease describes various techniques including target and signal amplification-based NAT procedures, microarrays, bead-based multiplex assays, in situ hybridization, and SNP techniques. This book discusses RNA expression profiling and laboratory issues such as the need for proper validation of tests intended fo

Author : Kay E. Davies
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.81/5 ( download)

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Download or read book Human Genetic Diseases written by Kay E. Davies and published by . This book was released on 1986 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all the commonly used methods for the analysis and diagnosis of human genetic diseases. The chapters cover the analysis of gene mutations as well as the functional organization of genes and chromosomal regions. The techniques for the analysis of human genetic disease have advanced so rapidly in recent years that almost all the chapters in this new edition have significant additions. For example, when the first edition of this book was published, prenatal diagnosis based on DNA analysis was performed in two weeks. The advent of PCR has changed this to just a few hours and has had an impact in almost all areas of molecular medicine. The expanded chapters now have sections also covering: fluorescence in situ hybridization (FISH), synthetic oligonucleotide hybridization, and pulsed-field gel electrophoresis. This book should be a valuable text for scientists working in a pure research environment as well as those in service laboratories analyzing different human disease mutations.

Author : Leonard S. Lerman
Publisher :
ISBN 13 :
Total Pages : 206 pages
Book Rating : 4.74/5 ( download)

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Download or read book DNA Probes written by Leonard S. Lerman and published by . This book was released on 1986 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Helen H. Lee
Publisher : Springer Science & Business Media
ISBN 13 : 9780817639211
Total Pages : 300 pages
Book Rating : 4.17/5 ( download)

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Download or read book Nucleic Acid Amplification Technologies written by Helen H. Lee and published by Springer Science & Business Media. This book was released on 1997-07-15 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing current information and guidance on the uses of various nucleic acid amplification technologies for clinical laboratory diagnosis, this book goes beyond the Polymerase Chain Reaction to explore a broader range of important alternative DNA/RNA amplification methods including the Ligase Chain Reaction, Q[beta] Replicase Assays and TMA. There are many examples of specific applications of these technologies, discussions of yet unresolved issues and demonstrations of the relevance of these technologies to medical research and disease diagnostics. Individual chapters cover uses of these methods in clinical situations such as detection of food pathogens, viral infections, STDs, Mycobacteria drug resistance mutations, and heritable diseases. Automation, diagnostic test evaluation, and the synthesis of artificial DNA are also discussed. This book is designed for all biomedical scientists interested in the application of molecular biology to clinical diagnosis.

Author : Marilena Aquino do Muro
Publisher : Humana
ISBN 13 : 9781617372360
Total Pages : 0 pages
Book Rating : 4.66/5 ( download)

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Download or read book Gene Probes written by Marilena Aquino do Muro and published by Humana. This book was released on 2010-11-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Senior scientists Marilena Aquino de Muro and Ralph Rapley have brought together an outstanding collection of time-tested protocols for designing and using genes probes in a wide variety of applications. The applications covered range from searching for specific genes in the human chromosome to the detection of microorganisms and their toxins in the environment and in food samples, as well as in the diagnosis of human disease. Helpful tutorials explain the principles of gene probe design, labeling, detection, target formation, and hybridization conditions.

Author : George H. Keller
Publisher :
ISBN 13 :
Total Pages : 696 pages
Book Rating : 4.85/5 ( download)

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Download or read book DNA Probes written by George H. Keller and published by . This book was released on 1993 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition is an updated version of the first edition, plus many new sections on specific applications of nucleic acid probes. Due to the explosion of such applications, experts in each major area have described their specialty. As in the first edition, the emphasis is on the commercial uses of DNA probes, as in diagnostic applications, and it incorporates background material, advice and specific protocols.