Nonhuman Primate Models For Human Diseases

Author : Joerg Bluemel
Publisher : Academic Press
ISBN 13 : 012417146X
Total Pages : 716 pages
Book Rating : 4.66/5 ( download)

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Download or read book The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment written by Joerg Bluemel and published by Academic Press. This book was released on 2015-03-13 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Author : W. Richard Dukelow
Publisher : CRC Press
ISBN 13 : 135109193X
Total Pages : 313 pages
Book Rating : 4.30/5 ( download)

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Download or read book Nonhuman Primate Models For Human Diseases written by W. Richard Dukelow and published by CRC Press. This book was released on 2018-02-06 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: While research has enabled us to better understand the nonhuman primates, they have repaid that by repaid that by providing medical scientists with important tools for the study of human biomedical problems. This book is about those research tools. The book was designed by identifying areas of human medical research that are under intensive research study today. Authors were then selected based on their expertise at using nonhuman primates as models for the human condition. Each was asked to use as comparative an approach as models for the human condition. Each was asked to use a comparative an approach as possible, to provide the reader with knowledge relating to the usefulness of various nonhuman primate species to each specific research area.

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309167949
Total Pages : 180 pages
Book Rating : 4.49/5 ( download)

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Download or read book Occupational Health and Safety in the Care and Use of Nonhuman Primates written by National Research Council and published by National Academies Press. This book was released on 2003-06-13 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of occupational health and safety constantly changes, especially as it pertains to biomedical research. New infectious hazards are of particular importance at nonhuman-primate facilities. For example, the discovery that B virus can be transmitted via a splash on a mucous membrane raises new concerns that must be addressed, as does the discovery of the Reston strain of Ebola virus in import quarantine facilities in the U.S. The risk of such infectious hazards is best managed through a flexible and comprehensive Occupational Health and Safety Program (OHSP) that can identify and mitigate potential hazards. Occupational Health and Safety in the Care and Use of Nonhuman Primates is intended as a reference for vivarium managers, veterinarians, researchers, safety professionals, and others who are involved in developing or implementing an OHSP that deals with nonhuman primates. The book lists the important features of an OHSP and provides the tools necessary for informed decision-making in developing an optimal program that meets all particular institutional needs.

Author : Christian R. Abee
Publisher : Academic Press
ISBN 13 : 0123978386
Total Pages : 868 pages
Book Rating : 4.87/5 ( download)

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Download or read book Nonhuman Primates in Biomedical Research written by Christian R. Abee and published by Academic Press. This book was released on 2012-06-07 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information Includes four color images throughout

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309220424
Total Pages : 200 pages
Book Rating : 4.22/5 ( download)

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Download or read book Chimpanzees in Biomedical and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2011-12-05 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.

Author : Christian R. Abee
Publisher : Academic Press
ISBN 13 : 9780123813664
Total Pages : 868 pages
Book Rating : 4.62/5 ( download)

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Download or read book Nonhuman Primates in Biomedical Research written by Christian R. Abee and published by Academic Press. This book was released on 2012-04-12 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information Includes four color images throughout

Author : Thomas Burbacher
Publisher : Academic Press
ISBN 13 : 9780080554068
Total Pages : 472 pages
Book Rating : 4.67/5 ( download)

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Download or read book Primate Models of Children's Health and Developmental Disabilities written by Thomas Burbacher and published by Academic Press. This book was released on 2011-10-10 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rate of neurodevelopmental disabilities, including autism, mental retardation, hearing loss and attention deficit hyperactivity disorder is rising in the United States. Although estimates of the prevalence of these disorders vary, figures from the CDC indicate that 4% of all school age children are developmentally disabled. During infancy, many important milestones in behavioral development are shared between human and nonhuman primates. Learning more about the causes of abnormal development in monkeys has provided important insights into the mechanisms underlying neurodevelopmental disabilities in human infants. This book documents the latest research not commonly found in other references, and provides a comprehensive look at the results from decades of work with nonhuman primates as it relates to child development and disability. Includes hot topics such as early chemical exposures, immunological influences on development, low birth weight, endocrine disrupters, pediatric AIDS, origin of childhood psychopathologies and assisted reproductive technology Represents the significant body of work accumulated since funding for research on developmental disabilities has increased substantially in recent years

Author : Busi Siddhardha
Publisher : Springer Nature
ISBN 13 : 9811516952
Total Pages : 685 pages
Book Rating : 4.55/5 ( download)

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Download or read book Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery written by Busi Siddhardha and published by Springer Nature. This book was released on 2020-03-28 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.

Author : Christian R. Abee
Publisher : Academic Press
ISBN 13 : 9780124158337
Total Pages : 0 pages
Book Rating : 4.31/5 ( download)

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Download or read book Nonhuman Primates in Biomedical Research,Two Volume Set written by Christian R. Abee and published by Academic Press. This book was released on 2012-04-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The publication emphasizes the biology and management, diseases, and biomedical models for nonhuman primate species most commonly used in research. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. The Biology and Management volume provides basic information on the natural biology of nonhuman primates and the current state of knowledge regarding captive management. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Now in four color throughout, making the book more visually stimulating to enhance learning and ease of use Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in biomedical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309176506
Total Pages : 184 pages
Book Rating : 4.07/5 ( download)

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Download or read book The Psychological Well-Being of Nonhuman Primates written by National Research Council and published by National Academies Press. This book was released on 1998-11-03 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: A 1985 amendment to the Animal Welfare Act requires those who keep nonhuman primates to develop and follow appropriate plans for promoting the animals' psychological well-being. The amendment, however, provides few specifics. The Psychological Well-Being of Nonhuman Primates recommends practical approaches to meeting those requirements. It focuses on what is known about the psychological needs of primates and makes suggestions for assessing and promoting their well-being. This volume examines the elements of an effective care program--social companionship, opportunities for species-typical activity, housing and sanitation, and daily care routines--and provides a helpful checklist for designing a plan for promoting psychological well-being. The book provides a wealth of specific and useful information about the psychological attributes and needs of the most widely used and exhibited nonhuman primates. Readable and well-organized, it will be welcomed by animal care and use committees, facilities administrators, enforcement inspectors, animal advocates, researchers, veterinarians, and caretakers.