Nitroglycerin

Author : P. Needleman
Publisher : Springer Science & Business Media
ISBN 13 : 364266024X
Total Pages : 206 pages
Book Rating : 4.45/5 ( download)

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Download or read book Organic Nitrates written by P. Needleman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease of the coronary arteries. The empirical observation of the safe use of nitrates for tile alleviation of the symptoms of angina have led to their widespread medical acceptance. The use of organic nitrates preceded any knowledge of their mechanism of action or their ultimate metabolic fate. Thus, more simply stated, although sub lingual nitrates helped the patients, little was known concerning what these drugs do to the body or what the body does to the drugs. A substantial number of investigators have focused on these questions especially during the last two decades. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents. Similarly, considerable effort has been expended in understanding the mechanism of action of these agents directly on vascular smooth muscle and on cardiac work and performance. Finally, there is a more substantive understanding of the physiology of the coronary circulation as well as the" pathophysiologic manifestations of myocardial disease.

Author : Subrata Bhadra
Publisher : GRIN Verlag
ISBN 13 : 3656475849
Total Pages : 135 pages
Book Rating : 4.42/5 ( download)

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Download or read book Nitroglycerin Sustained Release Tablet. Formulation Design and Evaluation written by Subrata Bhadra and published by GRIN Verlag. This book was released on 2013-08-07 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master's Thesis from the year 2010 in the subject Medicine - Pharmacology, Pharmacy, University of Dhaka (M. Pharm, in Pharmaceutical Technology), language: English, abstract: The aim of the present studies was to develop and characterize 2.6 mg sustained release matrix tablets of Nitroglycerin. Tablets were prepared by direct compression method. Methocel K15M CR and Methocel K100LV CR polymers were used as rate retarding agents in nine formulations (F-1 to F-9). The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, Carr’s index, Hausner ratio, moisture content, total porosity and assay. The tablets were subjected to diameter, thickness, assay, uniformity of content, assay after 1Month at 40°C+75%RH, hardness, friability, and in vitro dissolution studies. The granules showed satisfactory flow properties, compressibility, and drug content. All the tablet formulations showed acceptable pharmacotechnical properties and complied with pharmacopoeial specifications for tested parameters. The in vitro dissolution study was carried out for 8 hour using USP-2009 Apparatus-I (Rotating basket method) in distilled water as the dissolution medium. The release mechanisms were explored and explained by Zero order, First order, Higuchi, Korsmeyer-Peppas and Hixson-Crowell equations. Nine formulations were prepared by using three variable ratio of two polymers; Methocel K15M CR (25%, 20% and 15%) and Methocel K100LV CR (15%, 10% and 5%) where all the formulations (F-1 to F-9) contained 0.5% colloidal silicon dioxide and 1% magnesium stearate. Among these nine formulations, six formulations; F-2 (Methocel K15M CR: Methocel K100LV CR = 25% : 10%), F-3 (Methocel K15M CR : Methocel K100LV CR = 25% : 5%), F-4 (Methocel K15M CR : Methocel K100LV CR = 20% : 15%) F-5 (Methocel K15M CR: Methocel K100LV CR = 20% : 10%), F-6 (Methocel K15M CR : Methocel K100LV CR = 20% : 5%) and F-7 (Methocel K15M CR : Methocel K100LV CR = 15% : 15%) met the official specification of release profile. It was also found that the type and the amount of polymers significantly affect the time required for 50% (T50% or MDT) of drug release, release rate constant and diffusion exponent. Higher the MDT value indicates a higher drug retaining capacity of the polymers and vice-versa. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism of all proposed formulations followed anomalous type or non-Fickian transport (n>0.43 and n

Author : Charles D. Ciccone
Publisher : F.A. Davis
ISBN 13 : 0803640048
Total Pages : 1217 pages
Book Rating : 4.47/5 ( download)

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Download or read book Davis's Drug Guide for Rehabilitation Professionals written by Charles D. Ciccone and published by F.A. Davis. This book was released on 2013-03-21 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-of-a-kind guide specifically for rehabilitation specialists! A leader in pharmacology and rehabilitation, Charles Ciccone, PT, PhD offers a concise, easy-to-access resource that delivers the drug information rehabilitation specialists need to know. Organized alphabetically by generic name, over 800 drug monographs offer the most up-to-date information on drug indications, therapeutic effects, potential adverse reactions, and much more! A list of implications for physical therapy at the end of each monograph helps you provide the best possible care for your patients. It’s the perfect companion to Pharmacology in Rehabilitation, 4th Edition!

Author : P. Lichtlen
Publisher : Springer Science & Business Media
ISBN 13 : 3642680852
Total Pages : 713 pages
Book Rating : 4.54/5 ( download)

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Download or read book Nitrates III written by P. Lichtlen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacological and clinical research on nitrates continues to be of growing interest in many centers. This is surprising in view of the fact that their favorable effects in angina pectoris were described by Brunton and by Murrell in the Lancet more than 100 years ago. As expected, a host of new information has been collected since the two previous symposia on nitrates held in Stockholm in 1975 and Berlin in 1978. New insights were gained into the pharmacology, pharmacokinetics and pharmacodynamics of nitrates, as well as into their clinical effects in acute and chronic ischemic heart diseases and in severe congestive heart failure. Relatively little progress, however, was observed in research into the basic action of nitrates. Although most investigators agree that intracellular sequestration of calcium is probably the main mechanism by which nitrates lead to the reduction of vascular smooth muscle tone, the exact site of their action still remains undefined. In contrast, dose-dependent differences in venous and arteriolar tone have long been clearly established. Treatment was again in the main stream of discussion. The question of tolerance following long-term administration was discussed in depth and the term "pseudotolerance" was introduced to describe the adaptation of the body's circulatory system to chronic vasodilation. This is especially important in long term prophylactic antiischemic treatment in stable, as well as in unstable angina pectoris (i.e. during increased vasomotor tone - spasm).

Author : TALLARIDA
Publisher : Springer
ISBN 13 :
Total Pages : 412 pages
Book Rating : 4.07/5 ( download)

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Download or read book TOP 200 written by TALLARIDA and published by Springer. This book was released on 1982 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Jiping Liu
Publisher : Springer
ISBN 13 : 9811366470
Total Pages : 684 pages
Book Rating : 4.75/5 ( download)

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Download or read book Nitrate Esters Chemistry and Technology written by Jiping Liu and published by Springer. This book was released on 2019-03-06 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: The idea of this book is to present the up-to-date research results on Nitrate Esters as explosive materials. It covers many aspects including the material structures, nitrating agent, chemical synthesis devices, preparation technology, and applications etc. In particular, this work sheds light on the comprehensive utilization and thorough destruction of the used Nitrate Easters which is crucial for preventing repeated pollution. This is a highly informative and instructive book providing insight for the researchers working on nitrating theory, energetic materials and chemical equipments.

Author : Thomas Meinertz
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110809176
Total Pages : 136 pages
Book Rating : 4.76/5 ( download)

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Download or read book Nitroglycerin 9 written by Thomas Meinertz and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-10-12 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Nitroglycerin 9".

Author : P. G. Hugenholtz
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110870568
Total Pages : 108 pages
Book Rating : 4.65/5 ( download)

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Download or read book Nitroglycerin 7 written by P. G. Hugenholtz and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-07-08 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Nitroglycerin 7".

Author : Bodo E. Strauer
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110898268
Total Pages : 128 pages
Book Rating : 4.62/5 ( download)

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Download or read book Nitroglycerin 5 written by Bodo E. Strauer and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-10-08 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Nitroglycerin 5".

Author : Walter Otheman Snelling
Publisher :
ISBN 13 :
Total Pages : 18 pages
Book Rating : 4.34/5 ( download)

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Download or read book The Behavior of Nitroglycerin when Heated written by Walter Otheman Snelling and published by . This book was released on 1912 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: