New Insights Into Innate Immune Cell Based Immunotherapies In Cancer

Author : Mary Poupot-Marsan
Publisher : Frontiers Media SA
ISBN 13 : 2832548040
Total Pages : 256 pages
Book Rating : 4.42/5 ( download)

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Download or read book New insights into innate immune cell-based immunotherapies in cancer written by Mary Poupot-Marsan and published by Frontiers Media SA. This book was released on 2024-04-17 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Joseph D. Rosenblatt
Publisher : Springer Science & Business Media
ISBN 13 : 1461488095
Total Pages : 369 pages
Book Rating : 4.95/5 ( download)

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Download or read book Advances in Tumor Immunology and Immunotherapy written by Joseph D. Rosenblatt and published by Springer Science & Business Media. This book was released on 2013-10-25 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion. In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

Author : Rong-Fu Wang
Publisher : Springer Science & Business Media
ISBN 13 : 1441999140
Total Pages : 476 pages
Book Rating : 4.46/5 ( download)

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Download or read book Innate Immune Regulation and Cancer Immunotherapy written by Rong-Fu Wang and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.

Author : Jérôme Paggetti
Publisher : Frontiers Media SA
ISBN 13 : 2889742415
Total Pages : 164 pages
Book Rating : 4.17/5 ( download)

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Download or read book New Insights into the Complexity of Tumor Immunology in B-cell Malignancies: Disease Biology and Signaling written by Jérôme Paggetti and published by Frontiers Media SA. This book was released on 2022-01-31 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Jérôme Paggetti
Publisher : Frontiers Media SA
ISBN 13 : 2889742067
Total Pages : 191 pages
Book Rating : 4.66/5 ( download)

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Download or read book New Insights into the Complexity of Tumor Immunology in B-cell Malignancies: Tumor Immunology and Immunotherapy written by Jérôme Paggetti and published by Frontiers Media SA. This book was released on 2022-03-02 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor MS received funding from Bayer AG.

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309180686
Total Pages : 102 pages
Book Rating : 4.89/5 ( download)

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Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Author : Ahmed Lasfar
Publisher :
ISBN 13 : 9781789851465
Total Pages : pages
Book Rating : 4.67/5 ( download)

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Download or read book Tumor Progression and Metastasis written by Ahmed Lasfar and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Suzanne L. Walker
Publisher :
ISBN 13 : 9781635930184
Total Pages : pages
Book Rating : 4.89/5 ( download)

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Download or read book Guide to Immunotherapy written by Suzanne L. Walker and published by . This book was released on 2018-10 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Jianmei Wu Leavenworth
Publisher : Frontiers Media SA
ISBN 13 : 2889744736
Total Pages : 244 pages
Book Rating : 4.32/5 ( download)

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Download or read book Immune Cell Lineage Reprogramming in Cancer written by Jianmei Wu Leavenworth and published by Frontiers Media SA. This book was released on 2022-02-22 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Dr. Lewis Shi received financial support from Varian Medical System, Inc. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Author : Tim F. Greten
Publisher : Springer
ISBN 13 : 3319649582
Total Pages : 167 pages
Book Rating : 4.80/5 ( download)

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Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2017-10-04 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.