New Frontiers Extracellular Vesicles

Author : Suresh Mathivanan
Publisher : Springer Nature
ISBN 13 : 3030671712
Total Pages : 539 pages
Book Rating : 4.16/5 ( download)

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Download or read book New Frontiers: Extracellular Vesicles written by Suresh Mathivanan and published by Springer Nature. This book was released on 2021-03-29 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of extracellular vesicles (EVs) has progressed immensely in recent times with evidences highlighting their importance in physiology and pathology. This book entails extensive reflective literature on many subtypes of EVs including exosomes, exomeres, ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The book further discusses the biogenesis and secretion of these EVs, detailing the biological pathways and proteins involved. Research investigating the biological functions of EVs is rapidly increasing and the current knowledge around their role in progression of diseases such as cancer, neurodegeneration and metabolic disorders is discussed in multiple chapters. The implications of EVs in intercellular communication and the significance of biologically active cargo carried within these EVs are further examined. Moreover, the numerous applications of EVs in diagnostics and treatment of diseases are reviewed in detail, particularly their potential as biomarkers and drug delivery vehicles. Taken together, this book is a compilation of the key implications of EVs that are secreted by virtually all cell types. Readers will gain a perspective into the biology, functions and applications of EVs and their constantly evolving knowledge base.

Author :
Publisher :
ISBN 13 : 9783030671723
Total Pages : 539 pages
Book Rating : 4.20/5 ( download)

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Download or read book New Frontiers written by and published by . This book was released on 2021 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of extracellular vesicles (EVs) has progressed immensely in recent times with evidences highlighting their importance in physiology and pathology. This book entails extensive reflective literature on many subtypes of EVs including exosomes, exomeres, ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The book further discusses the biogenesis and secretion of these EVs, detailing the biological pathways and proteins involved. Research investigating the biological functions of EVs is rapidly increasing and the current knowledge around their role in progression of diseases such as cancer, neurodegeneration and metabolic disorders is discussed in multiple chapters. The implications of EVs in intercellular communication and the significance of biologically active cargo carried within these EVs are further examined. Moreover, the numerous applications of EVs in diagnostics and treatment of diseases are reviewed in detail, particularly their potential as biomarkers and drug delivery vehicles. Taken together, this book is a compilation of the key implications of EVs that are secreted by virtually all cell types. Readers will gain a perspective into the biology, functions and applications of EVs and their constantly evolving knowledge base.

Author : Erina Jimenez
Publisher : Foster Academics
ISBN 13 : 9781646465620
Total Pages : 0 pages
Book Rating : 4.28/5 ( download)

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Download or read book New Frontiers in Extracellular Vesicles written by Erina Jimenez and published by Foster Academics. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular vesicles (EVs) are lipid bilayer-delimited particles which are released naturally from nearly all types of cells but cannot replicate like cells. There are three types of EVs that are categorized on the basis of their size and synthesis route. These include apoptotic bodies, exosomes, and microvesicles. They transport a cargo of lipids, proteins, metabolites, nucleic acids and even parent cell organelles. The communication mechanism among cells relies heavily on EVs. They are also capable of carrying disease biomarkers, including CD24, glypican-1, CD63, and colon cancer-associated transcript 2 (CCAT2). Current research around EVs focuses on their role in various diseases and conditions such as cancer, neurodegeneration, metabolic disorders, and intercellular communication. Owing to their cargo delivery potential, EVs may be used as drug delivery platforms for cancer therapy. Furthermore, engineered EVs may find application in cancer combination therapy. This book explores the new frontiers in the study of extracellular vesicles. It is appropriate for students seeking detailed information on extracellular vesicles, as well as for experts.

Author :
Publisher : Academic Press
ISBN 13 : 0128206632
Total Pages : 316 pages
Book Rating : 4.38/5 ( download)

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Download or read book Extracellular Vesicles written by and published by Academic Press. This book was released on 2020-10-24 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular Vesicles, Volume 645 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Genetic labeling of extracellular vesicle exosomes for studying biogenesis and uptake in living mammalian cells, Fluorescent Labeling of Extracellular Vesicles, Isolation of extracellular vesicles from lymph, Transgenic rats for tracking body fluid/tissue-derived extracellular vesicles, Isolation of amniotic extracellular vesicles, Urinary extracellular vesicle isolation, Immunocapture-based ELISA to Characterize and Quantify Extracellular Vesicles in Both Cell Culture Supernatants and Body Fluids, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series

Author : Xiaoheng Liu
Publisher : Frontiers Media SA
ISBN 13 : 2832501621
Total Pages : 165 pages
Book Rating : 4.27/5 ( download)

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Download or read book New Insights Into Extracellular Vesicles in Cardiovascular Disease: Molecular Basis, Diagnosis and Therapy written by Xiaoheng Liu and published by Frontiers Media SA. This book was released on 2022-10-06 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.10/5 ( download)

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Download or read book Novel Clinical Applications of Extracellular Vesicles written by and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last years, the research on extracellular vesicles (EVs) has raised giving new insights into pathophysiology of several diseases. EVs are membrane-bound particles secreted by almost all cell types. Depending on their biogenesis and size they include exosomes, microparticles / microvesicles and apoptotic bodies. Characteristically, EVs carry markers from the source cell membrane and contain genetic material, lipids and proteins inside. They are known to play a role in cell-to-cell communication and to produce genotypic and phenotypic modifications in the target cell including: antigen presentation, apoptosis induction, cellular activation, inhibition or differentiation. In particular, increasing concentrations of EVs have been found in many diseases such as cancer, autoimmune and cardiovascular diseases, among others. Most of the studies in EVs are focused on the characterization of EVs compounds, identifying mechanism of action, their potential use as biomarkers, and few of them investigate a therapeutic usage. However, there are some issues to be achieved on the path to their clinical application. This research topic offers a common place to discuss current and novel clinical applications of EVs pointing on future directions. We encouraged the submission of original articles, reviews, hypothesis, controversies, future perspectives and personal viewpoints on the following topics of interest, but not limited to: • Contribution of EVs to better understand the pathology of immunological diseases. • Standardization of isolation and quantification protocols in the daily clinical practice. • Possible applications of EVs as clinical biomarkers (diagnostic, prognostic and evolution marker). • Therapeutic role of EVs being vehicles of specific cargo: current clinical trials? • Novel immunological functions of EVs.

Author : Andrew F Hill
Publisher : Humana
ISBN 13 : 9781493967261
Total Pages : 0 pages
Book Rating : 4.66/5 ( download)

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Download or read book Exosomes and Microvesicles written by Andrew F Hill and published by Humana. This book was released on 2016-12-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers methods for the analysis of extracellular vesicles (EV) that can be applied to isolated EVs from a wide variety of sources. This includes the use of electron microscopy, tunable resistance pulse sensing, and nanoparticle tracking analysis. The chapters in this book discuss EV cargoes containing proteins and genomic materials using a number of different approaches, and isolating EVs from platelets and neuronal cells and tissues. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and comprehensive, Exosomes and Microvesicles: Methods and Protocols is a valuable resource containing methodologies for anyone interested in researching EVs.

Author : Junjie Xiao
Publisher : Springer
ISBN 13 : 9811043973
Total Pages : 300 pages
Book Rating : 4.70/5 ( download)

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Download or read book Exosomes in Cardiovascular Diseases written by Junjie Xiao and published by Springer. This book was released on 2017-09-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.

Author : Claudio Galli
Publisher : Lippincott Williams & Wilkins
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.21/5 ( download)

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Download or read book Phospholipases and Prostaglandins written by Claudio Galli and published by Lippincott Williams & Wilkins. This book was released on 1978 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Yaoliang Tang
Publisher : Academic Press
ISBN 13 : 0128004975
Total Pages : 287 pages
Book Rating : 4.75/5 ( download)

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Download or read book Mesenchymal Stem Cell Derived Exosomes written by Yaoliang Tang and published by Academic Press. This book was released on 2015-09-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies