Network Spread Models Of Neurodegenerative Diseases

Author : Ashish Raj
Publisher : Frontiers Media SA
ISBN 13 : 2889457680
Total Pages : 116 pages
Book Rating : 4.87/5 ( download)

DOWNLOAD NOW!

Download or read book Network Spread Models of Neurodegenerative Diseases written by Ashish Raj and published by Frontiers Media SA. This book was released on 2019-04-18 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is a real pleasure to introduce the excellent papers contributed by leading experts to our Research Topic proposing various network models of dementia spread. The focus is strongly on disease-specific mathematical modeling rather than general graph theory. The emerging field of network neuroscience visualizes the brain as a graph consisting of nodes representing regions and edges as connections between them. This complex network supports efficient communication along neural projections, but also, unfortunately, the transmission and progression of Alzheimer’s and other neurodegenerative disorders. If we could know the brain’s network organization, could we then predict how degenerative processes might develop on this network? As these papers demonstrate, the answer is, increasingly, yes.

Author : Jesus Avila
Publisher : Royal Society of Chemistry
ISBN 13 : 1849732752
Total Pages : 306 pages
Book Rating : 4.58/5 ( download)

DOWNLOAD NOW!

Download or read book Animal Models for Neurodegenerative Disease written by Jesus Avila and published by Royal Society of Chemistry. This book was released on 2011-05-30 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, medical developments have resulted in an increase in human life expectancy. Some developed countries now have a larger population of individuals aged over 64 than those under 14. One consequence of the ageing population is a higher incidence of certain neurodegenerative disorders. In order to prevent these, we need to learn more about them. This book provides up-to-date information on the use of transgenic mouse models in the study of neurodegenerative disorders such as Alzheimer's and Huntington's disease. By reproducing some of the pathological aspects of the diseases, these studies could reveal the mechanism for their onset or development. Some of the transgenic mice can also be used as targets for testing new compounds with the potential to prevent or combat these disorders. The editors have extensive knowledge and experience in this field and the book is aimed at undergraduates, postgraduates and academics. The chapters cover disorders including: Alzheimer's disease, Parkinson's disease, Huntington's and other CAG diseases, amyotrophic lateral sclerosis (ALS), recessive ataxias, disease caused by prions, and ischemia.

Author : Diana Fernandes Lázaro
Publisher : Frontiers Media SA
ISBN 13 : 2889635074
Total Pages : 158 pages
Book Rating : 4.78/5 ( download)

DOWNLOAD NOW!

Download or read book Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases written by Diana Fernandes Lázaro and published by Frontiers Media SA. This book was released on 2020-02-20 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Carl Faingold
Publisher : Academic Press
ISBN 13 : 0124158641
Total Pages : 537 pages
Book Rating : 4.41/5 ( download)

DOWNLOAD NOW!

Download or read book Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics written by Carl Faingold and published by Academic Press. This book was released on 2013-12-26 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Author : Vaibhav A. Diwadkar
Publisher : Springer
ISBN 13 : 9783030597993
Total Pages : 488 pages
Book Rating : 4.97/5 ( download)

DOWNLOAD NOW!

Download or read book Brain Network Dysfunction in Neuropsychiatric Illness written by Vaibhav A. Diwadkar and published by Springer. This book was released on 2022-05-12 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain network function and dysfunction is the dominant model for understanding how the brain gives rise to normal and abnormal behavior. Moreover, neuropsychiatric illnesses continue to resist attempts to reveal an understanding of their bases. Thus, this timely volume provides a synthesis of the uses of multiple analytic methods as they are applied to neuroimaging data, to seek understanding of the neurobiological bases of psychiatric illnesses, understanding that can subsequently aid in their management and treatment. A principle focus is on the analyses and application of methods to functional magnetic resonance imaging (fMRI) data. fMRI remains the most widely used neuroimaging technique for estimating brain network function, and several of the methods covered can estimate brain network dysfunction in resting and task-active states. Additional chapters provide details on how these methods are (and can be) applied in the understanding of several neuropsychiatric disorders, including schizophrenia, mood disorders, autism, borderline personality disorder, and attention deficit hyperactivity disorder (ADHD). A final complement of chapters provides a collective overview of how this framework continues to provoke theoretical advances in our conception of the brain in psychiatry. This unique volume is designed to be a comprehensive resource for imaging researchers interested in psychiatry, and for psychiatrists interested in advanced imaging applications.

Author : Masamitsu Yamaguchi
Publisher : Springer
ISBN 13 : 9811305293
Total Pages : 308 pages
Book Rating : 4.90/5 ( download)

DOWNLOAD NOW!

Download or read book Drosophila Models for Human Diseases written by Masamitsu Yamaguchi and published by Springer. This book was released on 2018-06-27 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.

Author : Mathias Jucker
Publisher : Springer Science & Business Media
ISBN 13 : 3642354912
Total Pages : 163 pages
Book Rating : 4.15/5 ( download)

DOWNLOAD NOW!

Download or read book Proteopathic Seeds and Neurodegenerative Diseases written by Mathias Jucker and published by Springer Science & Business Media. This book was released on 2013-03-27 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer ́s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. ​

Author : Jonas H. Ellenberg
Publisher : CRC Press
ISBN 13 : 9780824788230
Total Pages : 600 pages
Book Rating : 4.30/5 ( download)

DOWNLOAD NOW!

Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

Author : Open University Course Team
Publisher :
ISBN 13 : 9780749251680
Total Pages : 200 pages
Book Rating : 4.89/5 ( download)

DOWNLOAD NOW!

Download or read book Random Walks and Diffusion written by Open University Course Team and published by . This book was released on 2009-10-21 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This block explores the diffusion equation which is most commonly encountered in discussions of the flow of heat and of molecules moving in liquids, but diffusion equations arise from many different areas of applied mathematics. As well as considering the solutions of diffusion equations in detail, we also discuss the microscopic mechanism underlying the diffusion equation, namely that particles of matter or heat move erratically. This involves a discussion of elementary probability and statistics, which are used to develop a description of random walk processes and of the central limit theorem. These concepts are used to show that if particles follow random walk trajectories, their density obeys the diffusion equation.

Author : Frank Wilcoxon
Publisher :
ISBN 13 :
Total Pages : 74 pages
Book Rating : 4.15/5 ( download)

DOWNLOAD NOW!

Download or read book Some Rapid Approximate Statistical Procedures written by Frank Wilcoxon and published by . This book was released on 1964 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: