Nanostructures For Antimicrobial And Antibiofilm Applications

Author : Ram Prasad
Publisher : Springer Nature
ISBN 13 : 3030403378
Total Pages : 461 pages
Book Rating : 4.79/5 ( download)

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Download or read book Nanostructures for Antimicrobial and Antibiofilm Applications written by Ram Prasad and published by Springer Nature. This book was released on 2020-05-12 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the pursuit of technological advancement in the field of biotechnology and pharmaceutical industries to counteract health issues, bacterial infections remain a major cause of morbidity and mortality. The ability of bacterial pathogens to form biofilms further agglomerates the situation by showing resistance to conventional antibiotics. To overcome this serious issue, bioactive metabolites and other natural products were exploited to combat bacterial infections and biofilm-related health consequences. Natural products exhibited promising results in vitro, however; their efficacy in in vivo conditions remain obscured due to their low-solubility, bioavailability, and biocompatibility issues. In this scenario, nanotechnological interventions provide a multifaceted platform for targeted delivery of bioactive compounds by slow and sustained release of drug-like compounds. The unique physico-chemical properties, biocompatibility and eco-friendly nature of bioinspired nanostructures has revolutionized the field of biology to eradicate microbial infections and biofilm-related complications. The green-nanotechnology based metal and metal oxide nanoparticles and polymeric nanoparticles have been regularly employed for antimicrobial and antibiofilm applications without causing damage to host tissues. The implications of these nanoparticles toward achieving sustainability in agriculture by providing systemic resistance against a variety of phytopathogens therefore plays crucial role in growth and crop productivity. Also the advent of smart and hybrid nanomaterials such as metal-based polymer nanocomposites, lipid-based nanomaterials and liposomes have the inherent potential to eradicate bacterial biofilm-related infections in an efficient manner. The recent development of carbon-based nanomaterials such as carbon nanotubes (CNTs) and silica based nanomaterials such as mesoporous silica nanoparticles (MSNs) also exploit a target of dreadful healthcare conditions such as cancer, immunomodulatory diseases, and microbial infections, as well as biofilm-related issues owing to their stability profile, biocompatibility, and unique physio-chemical properties. Recently novel physical approaches such as photothermal therapy (PTT) and antimicrobial photodynamic therapy (aPDT) also revolutionized conventional strategies and are engaged in eradicating microbial biofilm-related infections and related health consequences. These promising advancements in the development of novel strategies to treat microbial infections and biofilm-related multidrug resistance (MDR) phenomenon may provide new avenues and aid to conventional antimicrobial therapeutics.

Author : Anton Ficai
Publisher : Elsevier
ISBN 13 : 0323461514
Total Pages : 722 pages
Book Rating : 4.11/5 ( download)

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Download or read book Nanostructures for Antimicrobial Therapy written by Anton Ficai and published by Elsevier. This book was released on 2017-05-29 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. Shows how nanoantibiotics can be used to more effectively treat disease Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area

Author : Alexandru Grumezescu
Publisher : William Andrew
ISBN 13 : 0323428878
Total Pages : 576 pages
Book Rating : 4.73/5 ( download)

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Download or read book Nanobiomaterials in Antimicrobial Therapy written by Alexandru Grumezescu and published by William Andrew. This book was released on 2016-03-08 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiomaterials in Antimicrobial Therapy presents novel antimicrobial approaches that enable nanotechnology to be used effectively in the treatment of infections. This field has gained a large amount of interest over the last decade, in response to the high resistance of pathogens to antibiotics. Leading researchers from around the world discuss the synthesis routes of nanobiomaterials, characterization, and their applications as antimicrobial agents. The books covers various aspects: mechanisms of toxicity for inorganic nanoparticles against bacteria; the development of excellent carriers for the transport of a high variety of antimicrobials; the use of nanomaterials to facilitate both diagnosis and therapeutic approaches against infectious agents; strategies to control biofilms based on enzymes, biosurfactants, or magnetotactic bacteria; bacterial adhesion onto polymeric surfaces and novel materials; and antimicrobial photodynamic inactivation. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians. A methodical approach to this highly relevant subject for researchers, practitioners and students working in biomedical, biotechnological and engineering fields A valuable guide to recent scientific progress and the latest application methods Proposes novel opportunities and ideas for developing or improving technologies in nanomedicine and nanobiology

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
ISBN 13 : 0323527345
Total Pages : 574 pages
Book Rating : 4.47/5 ( download)

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Download or read book Antimicrobial Nanoarchitectonics written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2017-06-22 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial Nanoarchitectonics: From Synthesis to Applications brings together recent research in antimicrobial nanoparticles, specifically in the sustained and controlled delivery of antimicrobials. Particular attention is given to i) reducing the side effects of antibiotics, ii) increasing the pharmacological effect, and iii) improving aqueous solubility and chemical stability of different antimicrobials. In addition, antimicrobial nanoparticles in drug delivery are discussed extensively. The book also evaluates the pros and cons of using nanostructured biomaterials in the prevention and eradication of infections. It is an important reference resource for materials scientists and bioengineers who want to learn how nanomaterials are used in antimicrobial therapy. Provides readers with the information necessary to select the appropriate bionanomaterial to solve particular infection problems Includes case studies, showing how particular bionanomaterials have been used to cure infections Explains the central role that nanotechnology plays in modern antimicrobial therapy Evaluates the pros and cons of using nanostructured biomaterials in the prevention and eradication of infections

Author : Pratima R. Solanki
Publisher : Elsevier
ISBN 13 : 0323957579
Total Pages : 317 pages
Book Rating : 4.71/5 ( download)

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Download or read book Next-Generation Antimicrobial Nanocoatings for Medical Devices and Implants written by Pratima R. Solanki and published by Elsevier. This book was released on 2024-01-12 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Next-Generation Antimicrobial Nanocoatings for Medical Devices and Implants provides a detailed, up-to-date overview of nano-based antimicrobial coatings used to combat medical device-related biofilms. An introduction to biofilms and how they infect medical devices is included, as well as strategies/modification techniques used to target these biofilms. This book evaluates the various antimicrobial coatings formed using nanomaterials such as silver, inorganic materials, organic materials, carbon dots, surfactants, and electrospun fibers, specifically for us on medical devices and implants. Numerous coating methods are discussed along with the biological characterizations of these coating materials, and their toxicological and environmental impact.Next-generation Antimicrobial Nanocoatings for Medical Devices and Implants is a useful reference for materials scientists, biomedical engineers, and those working on the development of novel biomaterials for use in medical devices and implants. Provides a range of nanomaterials for use in antimicrobial coatings, including electrospun fibers, surfactants, carbon quantum dots, and more Details various modification approaches for targeting biofilms, as well as nanocoating characterization and methods for use on medical devices and implants Assesses the environmental and toxicological impact of antimicrobial nanocoatings

Author : Muthupandian Saravanan
Publisher : Elsevier
ISBN 13 : 0323998100
Total Pages : 790 pages
Book Rating : 4.09/5 ( download)

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Download or read book Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance written by Muthupandian Saravanan and published by Elsevier. This book was released on 2022-06-22 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance focuses on recent and emerging trends surrounding nanomaterials and nano-drug delivery approaches to combat antimicrobial resistance. The relationship between nanomaterials and antimicrobial activity needs to be deeply explored to meet the challenges of combating antimicrobial resistance. The content of this book is divided into three main topic areas, including (i) how to overcome the existing traditional approaches to combat antimicrobial resistance, (ii) applying multiple drug delivery mechanisms to target multi-drug resistant microbes, and (iii) how nanomaterials can be used as drug carriers. This is an important reference source for those looking to understand how nanotechnology plays an important role in combatting disease and infection. As antimicrobial resistance threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi, this is a timely resource. Outlines how to overcome existing traditional approaches to combatting antimicrobial resistance Explains how to apply multiple drug delivery mechanisms (MDR) to the target area in order to better combat antimicrobial resistance Shows how nanomaterials are used as drug carriers in this context

Author : Nicola Cioffi
Publisher : Springer Science & Business Media
ISBN 13 : 3642244289
Total Pages : 563 pages
Book Rating : 4.85/5 ( download)

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Download or read book Nano-Antimicrobials written by Nicola Cioffi and published by Springer Science & Business Media. This book was released on 2012-02-24 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a high demand for antimicrobials for the treatment of new and emerging microbial diseases. In particular, microbes developing multidrug resistance have created a pressing need to search for a new generation of antimicrobial agents, which are effective, safe and can be used for the cure of multidrug-resistant microbial infections. Nano-antimicrobials offer effective solutions for these challenges; the details of these new technologies are presented here. The book includes chapters by an international team of experts. Chemical, physical, electrochemical, photochemical and mechanical methods of synthesis are covered. Moreover, biological synthesis using microbes, an option that is both eco-friendly and economically viable, is presented. The antimicrobial potential of different nanoparticles is also covered, bioactivity mechanisms are elaborated on, and several applications are reviewed in separate sections. Lastly, the toxicology of nano-antimicrobials is briefly assessed.

Author : Rabah Boukherroub
Publisher : William Andrew
ISBN 13 : 032341737X
Total Pages : 338 pages
Book Rating : 4.72/5 ( download)

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Download or read book Functionalized Nanomaterials for the Management of Microbial Infection written by Rabah Boukherroub and published by William Andrew. This book was released on 2016-12-14 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functionalized Nanomaterials for the Management of Microbial Infection: A Strategy to Address Microbial Drug Resistance introduces the reader to the newly developing use of nanotechnology to combat microbial drug resistance. Excessive use of antibiotics and antimicrobial agents has produced an inexorable rise in antibiotic resistance in bacterial pathogens. The use of nanotechnology is currently the most promising strategy to overcome microbial drug resistance. This book shows how, due to their small size, nanoparticles can surmount existing drug resistance mechanisms, including decreased uptake and increased efflux of the drug from the microbial cell, biofilm formation, and intracellular bacteria. In particular, chapters cover the use of nanoparticles to raise intracellular antimicrobial levels, thus directly targeting sites of infection and packaging multiple antimicrobial agents onto a single nanoparticle. Provides the information users need to integrate antibacterial nanoparticles into future treatments Gives readers with backgrounds in nanotechnology, chemistry, and materials science an understanding of the main issues concerning microbial drug resistance and its challenges Includes real-life case studies that illustrates how functionalized nanomaterials are used to manage microbial infection

Author : Ana María Díez-Pascual
Publisher : MDPI
ISBN 13 : 3039439596
Total Pages : 228 pages
Book Rating : 4.91/5 ( download)

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Download or read book Recent Progress in Antimicrobial Nanomaterials written by Ana María Díez-Pascual and published by MDPI. This book was released on 2021-01-20 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a fundamental understanding of the interaction between bacteria and nanomaterials, this book highlights the latest research on the antimicrobial properties of nanomaterials and provides an invaluable blueprint for improving the antimicrobial performance of devices and products. This book introduces the reader to the progress being made in the field, followed by an outline of applications in different areas. Various methods and techniques of synthesis and characterization are detailed. The content provides insight into the ongoing research, current trends, and technical challenges in this rapidly progressing field. Therefore, this book is highly suitable for materials scientists, engineers, biologists, and technologists.

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
ISBN 13 : 0128136685
Total Pages : 690 pages
Book Rating : 4.83/5 ( download)

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Download or read book Design of Nanostructures for Versatile Therapeutic Applications written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2018-02-03 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design of Nanostructures for Versatile Therapeutic Applications focuses on antimicrobial, antioxidant and nutraceutical applications of nanostructured materials. Many books discuss these subjects, but not from a pharmaceutical point-of-view. This book covers novel approaches related to the modulation of microbial biofilms, antimicrobial therapy and encapsulate polyphenols as antioxidants. Written by an internationally diverse group of academics, this book is an important reference resource for researchers, both in biomaterials science and the pharmaceutical industry. Assesses the most recently developed nanostructures that have potential antimicrobial properties, explaining their novel mechanical aspects Shows how nanoantibiotics can be used to more effectively treat disease Provides a cogent summary of recent developments in nanoantimicrobial discovery, allowing readers to quickly familiarize themselves with the topic