Nanoplatform Based Molecular Imaging

Author : Xiaoyuan Chen
Publisher : John Wiley & Sons
ISBN 13 : 1118110021
Total Pages : 848 pages
Book Rating : 4.27/5 ( download)

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Download or read book Nanoplatform-Based Molecular Imaging written by Xiaoyuan Chen and published by John Wiley & Sons. This book was released on 2011-04-20 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cutting-edge guide on advancing the science of molecular imaging using nanoparticles Nanoplathform-Based Molecular Imaging provides rationale for using nanoparticle-based probes for molecular imaging, then discusses general strategies for this underutilized, yet promising, technology. It addresses general strategies of particle synthesis and surface chemistry, applications in computed tomography optical imaging, magnetic resonance imaging, ultrasound, multimodality imaging, theranostics, and finally, the clinical perspectives of nanoimaging. This comprehensive volume summarizes the opinions of those in the forefront of research and describes the latest developments by emphasizing fundamentals and initiating hands-on application.

Author : Mehdi Azizi
Publisher : Academic Press
ISBN 13 : 012824514X
Total Pages : 218 pages
Book Rating : 4.49/5 ( download)

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Download or read book Targeted Cancer Imaging written by Mehdi Azizi and published by Academic Press. This book was released on 2021-11-24 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models. Gives understanding of cancer biology that is appropriate for students and researchers in engineering and nanotechnology Demonstrates cancer targeting strategies of multifunctional nanotechnology-based imaging probes Shows how to design, synthesize and apply cancer imaging nanostructures

Author : Sixiang Shi
Publisher :
ISBN 13 :
Total Pages : 118 pages
Book Rating : 4.55/5 ( download)

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Download or read book Nanomaterials for Molecular Imaging written by Sixiang Shi and published by . This book was released on 2016 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular imaging, the "visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and other living systems", has played an important role in cancer diagnosis. With the advances in nanotechnology, nanomaterials have emerged as a promising candidate for molecular imaging, due to their unique properties. Graphene is one of the most promising nanomaterials, which is intrinsically useful for drug loading and photo therapy of cancer. However, in vivo biodistribution and tumor targeting with graphene nanomaterial is an underexplored area. In this dissertation, we designed a radiolabeled antibody conjugated reduced graphene oxide (RGO) nanoplatform for in vivo positron emission tomography (PET) and tumor vasculature targeting. Excellent tumor uptake was achieved with 64Cu-NOTA-RGO-TRC105, compared to non-targeted RGO conjugate (64Cu-NOTA-RGO). Various experiments were performed, demonstrating that the vasculature targeting is highly specific (Chapter 2). In the following study, graphene oxide (GO), another subtype of graphene nanomaterials, was conjugated with anti-angiogenesis protein vascular endothelial growth factor 121 (VEGF121) to further validate the active targeting and imaging of graphene nanomaterials. Significantly enhanced tumor accumulation (>8 %ID/g) as well as high tumor-to-muscle contrast was achieved, showing great potential for future tumor targeted imaging (Chapter 3). Although traditional chelators are generally utilized in radiolabeling and PET imaging of nanomaterials, a novel chelator-free radiolabeling approach was designed with graphene nanoparticles (Chapter 4). The chelator-free radiolabeled RGO possesses decent labeling efficiency and enhanced in vivo radiostability over NOTA-chelated RGO, making it especially suitable for nanoparticle-based radiolabeling. Bypassing the use of chemical chelator, the intrinsically radiolabeled nanoparticles are able to maintain the native pharmacokinetics, and therefore more accurately reflect the distribution in vivo. Besides graphene, layered double hydroxide (LDH) and molybdenum disulfide (MoS2) nanoparticles were also employed for chelator-free radiolabeling and examined in vivo (Chapter 5 and 6). Excellent tumor uptake and in vivo integrity were observed, further validating the potential of chelator-free labeling in molecular imaging. Taking advantaging of molecular imaging and nanotechnology, a promising multifunctional nanoplatform can be designed for in vivo cancer management. Further efforts are necessary to thoroughly understand the in vivo behavior of nanoparticles and apply them in clinic.

Author :
Publisher :
ISBN 13 :
Total Pages : 10 pages
Book Rating : 4.77/5 ( download)

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Download or read book Transferring Biomarker Into Molecular Probe written by and published by . This book was released on 2014 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developing multifunctional and easily prepared nanoplatforms with integrated different modalities is highly challenging for molecular imaging. Here, we report the successful transfer of an important molecular target, melanin, into a novel multimodality imaging nanoplatform. Melanin is abundantly expressed in melanotic melanomas and thus has been actively studied as a target for melanoma imaging. In our work, the multifunctional biopolymer nanoplatform based on ultrasmall (

Author : Vijay Mishra
Publisher : Academic Press
ISBN 13 : 0128097183
Total Pages : 552 pages
Book Rating : 4.82/5 ( download)

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Download or read book Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes written by Vijay Mishra and published by Academic Press. This book was released on 2017-05-23 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

Author : Peter J Hoskin
Publisher : Oxford University Press
ISBN 13 : 0198568428
Total Pages : 200 pages
Book Rating : 4.21/5 ( download)

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Download or read book Radiotherapy in Practice - Radioisotope Therapy written by Peter J Hoskin and published by Oxford University Press. This book was released on 2007-02-08 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioisotope therapy is an internal form of radiation, administered through liquid or injection, that treats cancer with minimal damage to the normal surrounding tissue. This book is a practical guide to radioisotope therapy, taking the reader through the basic principles, and then developing this by application to specific sites and diseases.

Author : Menka Khoobchandani
Publisher : Springer
ISBN 13 : 3319923994
Total Pages : 250 pages
Book Rating : 4.94/5 ( download)

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Download or read book Biotechnology Products in Everyday Life written by Menka Khoobchandani and published by Springer. This book was released on 2018-11-03 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores a sampling of the most powerful and enterprising efforts to achieve biotechnological goals by means of various interdisciplinary approaches. From the fabrication of extremely small units to achieve specific objectives through nano-bio-technology, to devices with artificial intelligence, gene therapy for cerebrovascular anomalies, biodegradable plastics, the use of phyto-stem cells in cosmetology, CarT cell immune therapy, targeted therapies for cancer, 3D printed bones developed by the University of Wollongong in Australia, the sickle cell chip developed by IIT Bombay, and innovative sustainable energy solutions, the book includes a colorful spectrum of reviews on current and future biotech products. Gathering contributions by an international team of researchers, this book offers its audience, and particularly younger readers, revealing information on current and upcoming smart technologies.

Author : Amitabha Acharya
Publisher : Springer Nature
ISBN 13 : 9811542805
Total Pages : 208 pages
Book Rating : 4.00/5 ( download)

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Download or read book Nanomaterial - Based Biomedical Applications in Molecular Imaging, Diagnostics and Therapy written by Amitabha Acharya and published by Springer Nature. This book was released on 2020-05-23 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the recent advances in nanomaterial-based molecular imaging, diagnostics, and personalized therapy. It discusses the novel biocompatible fluorescent nanomaterials, their synthesis, and modern state of art characterization, as well as the various strategies for immobilization of biomacromolecules on the nanomaterial surface and approaches for increasing their stability. In addition, the book describes the synthesis of lectin nanoconjugates using different types of biocompatible raw materials and their systematic characterization. Lastly, it presents our current understanding of the biomolecular carona, which affects nanoparticle-based targeted drug delivery, and examines the conceptual approaches to improve the in-vivo efficacy of targeted drug delivery.

Author : Habib Zaidi
Publisher : Saunders
ISBN 13 : 9781416049883
Total Pages : 240 pages
Book Rating : 4.86/5 ( download)

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Download or read book Instrumentation, an Issue of Pet Clinics written by Habib Zaidi and published by Saunders. This book was released on 2008-03 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently there is no shortage of challenges and opportunities for PET instrumentation and quantitative imaging techniques. Molecular imaging technologies are leading to a revolutionary paradigm shift in health care and clinical practice. This issue reviews recent advances in PET instrumentation as well as volume correction strategies and strategies for motion tracking and correction, scatter compensation techniques, and attenuation correction techniques.

Author : Michael R. Hamblin
Publisher : Elsevier
ISBN 13 : 1908818786
Total Pages : 573 pages
Book Rating : 4.82/5 ( download)

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Download or read book Applications of Nanoscience in Photomedicine written by Michael R. Hamblin and published by Elsevier. This book was released on 2015-02-17 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoscience has become one of the key growth areas in recent years. It can be integrated into imaging and therapy to increase the potential for novel applications in the field of photomedicine. In the past commercial applications of nanoscience have been limited to materials science research only, however, in recent years nanoparticles are rapidly being incorporated into industrial and consumer products. This is mainly due to the expansion of biomedical related research and the burgeoning field of nanomedicine. Applications of Nanoscience in Photomedicine covers a wide range of nanomaterials including nanoparticles used for drug delivery and other emerging fields such as optofluidics, imaging and SERS diagnostics. Introductory chapters are followed by a section largely concerned with imaging, and finally a section on nanoscience-enabled therapeutics. Covers a comprehensive up-to-date information on nanoscience Focuses on the combination of photomedicine with nanotechnology to enhance the diversity of applications Pioneers in the field have written their respective chapters Opens a plethora of possibilities for developing future nanomedicine Easy to understand and yet intensive coverage chapter by chapter