Multimodal And Longitudinal Bioimaging Methods For Characterizing The Progressive Course Of Dementia

Author : Javier Ramírez
Publisher : Frontiers Media SA
ISBN 13 : 2889459497
Total Pages : 168 pages
Book Rating : 4.90/5 ( download)

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Download or read book Multimodal and Longitudinal Bioimaging Methods for Characterizing the Progressive Course of Dementia written by Javier Ramírez and published by Frontiers Media SA. This book was released on 2019-08-12 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : M. Filippi
Publisher : Springer Science & Business Media
ISBN 13 : 8847022347
Total Pages : 188 pages
Book Rating : 4.48/5 ( download)

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Download or read book Primary Progressive Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin ical trials have excluded PPMS patients on two counts. Clinical worsening devel ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the ~-interferons and glatiramer acetate, preliminary, uncontrolled clinical experi ence suggests that the results may not be dramatic.

Author : Agustín Ibáñez
Publisher : Frontiers Media SA
ISBN 13 : 2889454940
Total Pages : 217 pages
Book Rating : 4.45/5 ( download)

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Download or read book Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America written by Agustín Ibáñez and published by Frontiers Media SA. This book was released on 2018-06-21 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.

Author : Roberto Cabeza
Publisher : Oxford University Press
ISBN 13 : 0199372934
Total Pages : 633 pages
Book Rating : 4.35/5 ( download)

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Download or read book Cognitive Neuroscience of Aging written by Roberto Cabeza and published by Oxford University Press. This book was released on 2017 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: A rapidly growing body of research has consituted a new discipline that may be called cognitive neuroscience of aging. This book offers an introduction to the topic, useful to both professionals & students in cognitive neuroscience, cognitive psychology, neuroscience, neuropsychology & neurology.

Author : Heiko Braak
Publisher : Springer
ISBN 13 : 3319126792
Total Pages : 168 pages
Book Rating : 4.91/5 ( download)

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Download or read book Neuroanatomy and Pathology of Sporadic Alzheimer's Disease written by Heiko Braak and published by Springer. This book was released on 2014-12-11 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail

Author : Yoshiaki Toyama
Publisher : Springer Nature
ISBN 13 : 9811379084
Total Pages : 292 pages
Book Rating : 4.86/5 ( download)

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Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.

Author : Padma V. Devarajan
Publisher : Springer
ISBN 13 : 3319113550
Total Pages : 788 pages
Book Rating : 4.55/5 ( download)

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Download or read book Targeted Drug Delivery : Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Author : Ayman El-Baz
Publisher : IOP Publishing Limited
ISBN 13 : 9780750327213
Total Pages : 285 pages
Book Rating : 4.19/5 ( download)

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Download or read book Neurological Disorders Imaging Physics written by Ayman El-Baz and published by IOP Publishing Limited. This book was released on 2020-07-16 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on major trends and challenges in the area of dyslexia, epilepsy and Parkinson's, and aims to identify new techniques and their applications in biomedical analysis. This fifth volume on neurological disorders explores topics such as real-time epilepsy prediction applied on EEG pediatric data; delineation of epileptogenic zone; behavioral and biological correlates and treatment of dyslexia; potential biomarkers of Parkinson's disease; Rett Syndrome; and automatic assessment of motor impairments for Parkinson's disease. This is an essential reference for students and researchers in medical imaging, brain imaging, image processing, and neurology. Key Features World class contributors in neurological disorders imaging Presents a comprehensive review of imaging related dyslexia, epilepsy and Parkinson's Introductory section presents the fundamentals of various imaging techniques

Author : Leonardo Pantoni
Publisher : Cambridge University Press
ISBN 13 : 1107031664
Total Pages : 375 pages
Book Rating : 4.61/5 ( download)

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Download or read book Cerebral Small Vessel Disease written by Leonardo Pantoni and published by Cambridge University Press. This book was released on 2014-05 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.

Author : Reid R. Heffner
Publisher :
ISBN 13 :
Total Pages : 256 pages
Book Rating : 4.24/5 ( download)

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Download or read book Muscle Pathology written by Reid R. Heffner and published by . This book was released on 1984 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: