Multi Copper Oxidases

Author : Albrecht Messerschmidt
Publisher : World Scientific
ISBN 13 : 9810227116
Total Pages : 477 pages
Book Rating : 4.11/5 ( download)

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Download or read book Multi-copper Oxidases written by Albrecht Messerschmidt and published by World Scientific. This book was released on 1997 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biological activation of dioxygen is a key reaction in biological systems. Enzymes involved in direct oxygen activation are oxidases and oxygenases. Multi-copper oxidases are an important class of oxidases reducing dioxygen in a four-electron reduction to water with concomitant one-electron oxidation of the reducing substrate. The progress in the characterization and understanding of the structure and function of these enzymes has advanced so tremendously over the last ten years that the publication of a book documenting these achievements has been overdue.Especially the recent discovery of a key role of the FET3 protein of Saccharomyces cerevisae, a multi-copper oxidase, in iron metabolism of this eukaryote has underpinned the function of the plasma multi-copper oxidase ceruloplasmin in vetebrate iron transport. The lately determined x-ray structure of human ceruloplasmin confirms its close structural relatedness to the plant multi-copper oxidases ascorbate oxidase and laccase and due to strong amino-acid sequence similarities has allowed to construct a useful model of the more distantly related blood-clotting factor VIII.This book contains review articles from experts in the field, dealing with modern spectroscopy, enzyme kinetics, bioinorganic chemistry, x-ray crystallography, electron transfer reactions, molecular biology, medical aspects and potential industrial applications of the three main members of multi-copper oxidases, i.e., laccase, ascorbate oxidase and ceruloplasmin.

Author : Kenji Kano
Publisher : Springer Nature
ISBN 13 : 9811589607
Total Pages : 135 pages
Book Rating : 4.07/5 ( download)

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Download or read book Enzymatic Bioelectrocatalysis written by Kenji Kano and published by Springer Nature. This book was released on 2020-11-13 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the fundamental aspects of the electrochemistry and redox enzymes that underlie enzymatic bioelectrocatalysis, in which a redox enzyme reaction is coupled with an electrode reaction. Described here are the basic concept and theoretical aspects of bioelectrocatalysis and the various experimental techniques and materials used to study and characterize related problems. Also included are the various applications of bioelectrocatalysis to bioelectrochemical devices including biosensors, biofuel cells, and bioreactors. This book is a unique source of information in the area of enzymatic bioelectrocatalysis, approaching the subject from a cross-disciplinary point of view.

Author : Chang Cui
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.10/5 ( download)

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Download or read book Engineering Heme-copper and Multi-copper Oxidases for Efficient Oxygen Reduction Catalysis written by Chang Cui and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Xiaoyu Wang
Publisher : Springer
ISBN 13 : 3662530686
Total Pages : 134 pages
Book Rating : 4.89/5 ( download)

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Download or read book Nanozymes: Next Wave of Artificial Enzymes written by Xiaoyu Wang and published by Springer. This book was released on 2016-07-27 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the fundamental concepts, the latest developments and the outlook of the field of nanozymes (i.e., the catalytic nanomaterials with enzymatic characteristics). As one of today’s most exciting fields, nanozyme research lies at the interface of chemistry, biology, materials science and nanotechnology. Each of the book’s six chapters explores advances in nanozymes. Following an introduction to the rise of nanozymes research in the course of research on natural enzymes and artificial enzymes in Chapter 1, Chapters 2 through 5 discuss different nanomaterials used to mimic various natural enzymes, from carbon-based and metal-based nanomaterials to metal oxide-based nanomaterials and other nanomaterials. In each of these chapters, the nanomaterials’ enzyme mimetic activities, catalytic mechanisms and key applications are covered. In closing, Chapter 6 addresses the current challenges and outlines further directions for nanozymes. Presenting extensive information on nanozymes and supplemented with a wealth of color illustrations and tables, the book offers an ideal guide for readers from disparate areas, including analytical chemistry, materials science, nanoscience and nanotechnology, biomedical and clinical engineering, environmental science and engineering, green chemistry, and novel catalysis.

Author : Sreedhar Kilaru
Publisher : Cuvillier Verlag
ISBN 13 : 3867270961
Total Pages : 398 pages
Book Rating : 4.60/5 ( download)

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Download or read book Identification of Fungal Multi-copper Oxidase Gene Families written by Sreedhar Kilaru and published by Cuvillier Verlag. This book was released on 2006 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Timothy E. Machonkin
Publisher :
ISBN 13 :
Total Pages : 670 pages
Book Rating : 4.08/5 ( download)

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Download or read book Spectroscopic and Biochemical Studies of Multicopper Oxidases Involved in Iron Metabolism written by Timothy E. Machonkin and published by . This book was released on 2000 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Zeyu Peng
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.36/5 ( download)

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Download or read book Characterization of Multicopper Oxidase-related Protein and Multicopper Oxidase-1 in Insects written by Zeyu Peng and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Typical multicopper oxidases (MCOs) have ten conserved histidines and one conserved cysteine that coordinate four copper atoms, which are required for oxidase activity. During our studies of insect MCOs, we discovered a gene that we named multicopper oxidase-related protein (MCORP). MCORPs share sequence identity with MCOs, but lack many of the copper-coordinating residues. We identified MCORP orthologs in many insect species, but not in other invertebrates or vertebrates. We purified recombinant Tribolium castaneum (red flour beetle) MCORP. As expected, no oxidase activity was detected. We analyzed expression profiles of TcMCORP and Anopheles gambiae (African malaria mosquito) MCORP. They are constitutively expressed at a low level in many tissues, including ovaries. TcMCORP larval RNAi led to 100% mortality before adult stage. These deaths occurred during the larval to pupal and pupal to adult molts. Pharate pupal RNAi resulted in 20% mortality during the pupal to adult molt, and 100% mortality by one month after adult eclosion. In addition, knockdown of TcMCORP in females prevented oocyte maturation, thus greatly decreasing the number of eggs laid. These results indicate that TcMCORP is an essential gene and that its function is required for reproduction. An understanding of the role MCORP plays in insect physiology may help to develop new strategies for controlling insect pests. A multicopper oxidase-1 (MCO1) ortholog has been identified in all insect species examined so far; thus, MCO1 probably has a conserved physiological function in insects. Most of the well-studied MCOs are laccases, ferroxidases, or ascorbate oxidases. Previously we found Drosophila melanogaster MCO1 has ferroxidase activity and we identified three putative iron binding residues in DmMCO1. Our kinetic analysis of recombinant MCO1 from Drosophila melanogaster, Anopheles gambiae, Tribolium castaneum and Manduca sexta showed that MCO1 orthologs are much better at oxidizing ascorbate than laccase substrates or ferrous iron, suggesting that MCO1 orthologs function as ascorbate oxidases. The putative iron binding residues are required for ascorbate oxidase activity but not ferroxidase and laccase activities. Ascorbate oxidases have been identified only in plants. This is the first identification of ascorbate oxidase in insects. Further studies are needed to understand their physiological function in insects.

Author : Fausto Almeida
Publisher : Frontiers Media SA
ISBN 13 : 2889661326
Total Pages : 167 pages
Book Rating : 4.29/5 ( download)

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Download or read book The Fungal Cell Wall written by Fausto Almeida and published by Frontiers Media SA. This book was released on 2020-11-19 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Amy Elizabeth Palmer
Publisher :
ISBN 13 :
Total Pages : 464 pages
Book Rating : 4.46/5 ( download)

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Download or read book Spectroscopic Studies of Multicopper Oxidases : Probing the Nature and Reactivity of the Different Copper Sites written by Amy Elizabeth Palmer and published by . This book was released on 2001 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Wilhelmina May Huston
Publisher :
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.15/5 ( download)

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Download or read book Identification and Characterisation of Bacterial Multi-copper Oxidases and Their Potential Role in Iron Acquisition written by Wilhelmina May Huston and published by . This book was released on 2003 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: