Mucosal Vaccination Strategies To Induce And Evaluate Mucosal Immunity

Author : Andreas Frey
Publisher : Frontiers Media SA
ISBN 13 : 2889762165
Total Pages : 241 pages
Book Rating : 4.63/5 ( download)

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Download or read book Mucosal Vaccination: Strategies to Induce and Evaluate Mucosal Immunity written by Andreas Frey and published by Frontiers Media SA. This book was released on 2022-05-25 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Hiroshi Kiyono
Publisher : Elsevier
ISBN 13 : 0080537057
Total Pages : 501 pages
Book Rating : 4.54/5 ( download)

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Download or read book Mucosal Vaccines written by Hiroshi Kiyono and published by Elsevier. This book was released on 1996-10-23 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.14/5 ( download)

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Download or read book Strategies for the Induction of Mucosal Immunity Against Hepatitis B Virus written by and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Pamela A. Kozlowski
Publisher : Springer Science & Business Media
ISBN 13 : 3642236936
Total Pages : 204 pages
Book Rating : 4.38/5 ( download)

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Download or read book Mucosal Vaccines written by Pamela A. Kozlowski and published by Springer Science & Business Media. This book was released on 2012-01-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.

Author : Pamela A. Kozlowski
Publisher : Springer
ISBN 13 : 9783642236945
Total Pages : 198 pages
Book Rating : 4.44/5 ( download)

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Download or read book Mucosal Vaccines written by Pamela A. Kozlowski and published by Springer. This book was released on 2012-01-26 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309174988
Total Pages : 472 pages
Book Rating : 4.85/5 ( download)

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Download or read book Vaccines for the 21st Century written by Institute of Medicine and published by National Academies Press. This book was released on 2001-02-21 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have made it possible to eradicate the scourge of smallpox, promise the same for polio, and have profoundly reduced the threat posed by other diseases such as whooping cough, measles, and meningitis. What is next? There are many pathogens, autoimmune diseases, and cancers that may be promising targets for vaccine research and development. This volume provides an analytic framework and quantitative model for evaluating disease conditions that can be applied by those setting priorities for vaccine development over the coming decades. The committee describes an approach for comparing potential new vaccines based on their impact on morbidity and mortality and on the costs of both health care and vaccine development. The book examines: Lessons to be learned from the polio experience. Scientific advances that set the stage for new vaccines. Factors that affect how vaccines are used in the population. Value judgments and ethical questions raised by comparison of health needs and benefits. The committee provides a way to compare different forms of illness and set vaccine priorities without assigning a monetary value to lives. Their recommendations will be important to anyone involved in science policy and public health planning: policymakers, regulators, health care providers, vaccine manufacturers, and researchers.

Author : Virgil Schijns
Publisher : Elsevier
ISBN 13 : 0080457215
Total Pages : 396 pages
Book Rating : 4.15/5 ( download)

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Download or read book Immunopotentiators in Modern Vaccines written by Virgil Schijns and published by Elsevier. This book was released on 2005-12-19 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. Contributions from leading international authorities in the field Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator

Author : Dominiek Maes
Publisher : CABI
ISBN 13 : 1789249945
Total Pages : 346 pages
Book Rating : 4.41/5 ( download)

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Download or read book Mycoplasmas in Swine written by Dominiek Maes and published by CABI. This book was released on 2021-03-12 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Swine can be infected with many different mycoplasmas. Some are important pathogens, causing significant health and welfare issues in pigs and major losses to the swine industry worldwide. Other mycoplasmas are not pathogenic for swine and can be considered commensals. This book provides up-to-date scientific, clinical and practical information of the most important pathogenic mycoplasmas in swine. Most emphasis has been placed on Mycoplasma hyopneumoniae as the most economically important, but other pathogenic species like Mycoplasma hyorhinis, Mycoplasma hyosynoviae and Mycoplasma suis are also discussed. Written by internationally renowned scientists and clinicians from all over the world, this book draws together in depth knowledge, expertise and experience in swine mycoplasmas to provide an evidence-based, academically rigorous and practical collection. It aims to serve the scientific and veterinary community and the swine industry worldwide.

Author : Shaswath Sekar Chandrasekar
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.47/5 ( download)

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Download or read book Development of Mucosal Vaccine Strategies Against Respiratory Coronaviruses written by Shaswath Sekar Chandrasekar and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Respiratory coronaviruses (rCoVs) cause acute respiratory disease in various animal hosts like infectious bronchitis virus (IBV) in chickens, porcine respiratory CoV (PRCoV) in pigs and SARS-CoV-2 in humans. rCoVs negatively impact the welfare of animals and consequently affects the livelihoods of people and industries that depend on them. Therefore, to develop potent vaccines for the control of rCoVs, we explored nanovaccine strategies based on plasmid DNA and viral vector platforms delivered via the intranasal route against IBV and SARS-CoV-2. A novel nanoadjuvant system, QAC (quil-a and chitosan), was developed to deliver plasmid DNA immunogens via the intranasal route. Plasmid DNA vaccines are poorly immunogenic by themselves, and nucleases present in the mucosal tract can limit their bioavailability. The QAC adjuvant system, based on quil-A and chitosan, formed mucoadhesive nanoparticles when encapsulating plasmid DNA, ensuring protection and intranasal delivery of the DNA immunogens. Immunization of birds with QAC-encapsulated plasmid DNA encoding for IBV N protein (pQAC-N) protected chickens against virulent IBV challenge as shown by reduction in viral burden and alleviating clinical signs. Furthermore, pQAC-N immunization elicited lung IBV responsive CD8+ and TCR[gamma][delta]+ T-cells, a potential hallmark of QAC adjuvant mechanism. In a heterologous prime-boost vaccination strategy, a Modified Vaccinia Ankara (MVA) viral vector encoding for IBV N (MVA-N) was administered intranasally as a booster dose two weeks after pQAC-N priming. Similar to homologous pQAC-N vaccination, the heterologous vaccination reduced viral load and clinical severity with an expansion of IBV-specific lung T-cells in immunized birds. In contrast, we did not observe comparable protection with homologous MVA-N prime-boost vaccination, indicating that heterologous vaccination strategy is more immunogenic and protective than homologous vaccination. The developed mucosal vaccine strategies were translated for use against SARS-CoV-2 in K18-hACE2 mice. The heterologous prime-boost vaccination (pQAC/MVA-CoV) expressing both SARS-CoV-2 S and N elicited only mucosal T-cell and neutralizing responses that limited viral replication in the lungs of immunized mice. In contrast, parenteral administration of QAC encapsulated constructs encoding for S and N elicited systemic neutralizing immune responses that prevented both viral replication in the lungs and prevented dissemination to distal sites protecting against SARS-CoV-2 clinical outcomes. Our study indicates that mucosal immune responses elicited by intranasal administration are sufficient for reducing local viral replication, but systemic responses are required to prevent viral dissemination. In summary, we have attempted to highlight the importance and ability of local mucosal immune responses in limiting rCoV replication using IBV and SARS-CoV-2 models. Also, by developing a novel nanoadjuvant system, we extended the utility of plasmid DNA vaccines for intranasal delivery.

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309219396
Total Pages : 570 pages
Book Rating : 4.96/5 ( download)

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Download or read book The Science and Applications of Synthetic and Systems Biology written by Institute of Medicine and published by National Academies Press. This book was released on 2011-12-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.