Mouse Genetics And Transgenics

Author : Ian J. Jackson
Publisher : OUP Oxford
ISBN 13 : 0191565830
Total Pages : 324 pages
Book Rating : 4.30/5 ( download)

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Download or read book Mouse Genetics and Transgenics written by Ian J. Jackson and published by OUP Oxford. This book was released on 1999-12-09 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique book that integrates knowledge from a wide range of expertise, specifically applied to the mouse, and addressed at a wide audience from those new to the field to experts who want an update on the state of the art. Mouse Genetics and Transgenics: APA covers all aspects of using the mouse as a genetic model organism: care & husbandry; archiving stocks as frozen embryos or sperm; making new mutations by chemical mutagenesis; transgenesis; and gene targetting; mapping mutations and polygenic traits by cytogenetic, genetic, and physical means; and disseminating and researching information via the Internet.

Author : Shree Ram Singh
Publisher : Humana
ISBN 13 : 9781071610077
Total Pages : 217 pages
Book Rating : 4.74/5 ( download)

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Download or read book Mouse Genetics written by Shree Ram Singh and published by Humana. This book was released on 2021-02-20 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated edition provides selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages, and modeling human diseases. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mouse Genetics: Methods and Protocols, Second Edition delivers fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students, and postdoctoral fellows working in the various disciplines of genetics, developmental biology, mouse genetics, and modeling human diseases.

Author : Jean Louis Guénet
Publisher : Springer
ISBN 13 : 3662442876
Total Pages : 417 pages
Book Rating : 4.76/5 ( download)

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Download or read book Genetics of the Mouse written by Jean Louis Guénet and published by Springer. This book was released on 2014-11-29 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

Author : Marten H. Hofker
Publisher : Springer Science & Business Media
ISBN 13 : 1592593402
Total Pages : 382 pages
Book Rating : 4.08/5 ( download)

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Download or read book Transgenic Mouse Methods and Protocols written by Marten H. Hofker and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.

Author : Professor of Molecular Biology Lee M Silver, Professor Dr
Publisher : Oxford University Press on Demand
ISBN 13 : 9780195075540
Total Pages : 362 pages
Book Rating : 4.44/5 ( download)

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Download or read book Mouse Genetics written by Professor of Molecular Biology Lee M Silver, Professor Dr and published by Oxford University Press on Demand. This book was released on 1995 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interpreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.

Author : Robert P. Erickson
Publisher : Academic Press
ISBN 13 : 0128240172
Total Pages : 346 pages
Book Rating : 4.75/5 ( download)

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Download or read book Twentieth Century Mouse Genetics written by Robert P. Erickson and published by Academic Press. This book was released on 2021-08-26 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and updates connecting historic research to ongoing advances. Past studies discussed use the T/t complex as an example and include the origins of mouse genetics, the synthesis of genetics and evolution, cytogenetics and gene mapping, population genetics and mutation research, immunogenetics, reproductive genetics, molecular cloning, X-inactivation and epigenetics, sex determination, and pharmacogenetics. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models and to translate those findings to clinical practice. Offers a comprehensive examination of key advances in mouse genetics throughout the 20th century Includes updates connecting historic research to ongoing advances Authored by a thought-leader in the field

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309172829
Total Pages : 113 pages
Book Rating : 4.20/5 ( download)

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Download or read book Microbial and Phenotypic Definition of Rats and Mice written by National Research Council and published by National Academies Press. This book was released on 1999-07-26 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: US-Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US-Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic of Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes published in 1991. In addition to these publications, these meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.

Author : Melissa A. Larson
Publisher : Humana
ISBN 13 : 9781493998395
Total Pages : 236 pages
Book Rating : 4.90/5 ( download)

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Download or read book Transgenic Mouse written by Melissa A. Larson and published by Humana. This book was released on 2020-09-12 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with a historical foundation in standard techniques and a comprehensive update on the latest methods used in making gene-modified mice. The chapters in this book cover topics such as pronuclear microinjection in one-cell embryos; embryo transfer surgery; nuclear transfer and cloning; blastocyst microinjection; and cryobanking and recovery of genetically modified mice. Importantly, there are chapters devoted to the latest application of CRISPR technology, as well as the establishment of induced pluripotent stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Transgenic Mouse: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field.

Author : Jerry J. Buccafusco
Publisher : CRC Press
ISBN 13 : 1420041819
Total Pages : 341 pages
Book Rating : 4.11/5 ( download)

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Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Author : Edward D. Levin
Publisher : CRC Press
ISBN 13 : 1420004336
Total Pages : 395 pages
Book Rating : 4.35/5 ( download)

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Download or read book Animal Models of Cognitive Impairment written by Edward D. Levin and published by CRC Press. This book was released on 2006-06-22 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen