Motif Tools

Author : Altuna Akalin
Publisher : CRC Press
ISBN 13 : 1498781861
Total Pages : 462 pages
Book Rating : 4.62/5 ( download)

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Download or read book Computational Genomics with R written by Altuna Akalin and published by CRC Press. This book was released on 2020-12-16 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.

Author : Wang, John
Publisher : IGI Global
ISBN 13 : 159904952X
Total Pages : 4092 pages
Book Rating : 4.26/5 ( download)

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Download or read book Data Warehousing and Mining: Concepts, Methodologies, Tools, and Applications written by Wang, John and published by IGI Global. This book was released on 2008-05-31 with total page 4092 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the science of managing and analyzing large datasets has emerged as a critical area of research. In the race to answer vital questions and make knowledgeable decisions, impressive amounts of data are now being generated at a rapid pace, increasing the opportunities and challenges associated with the ability to effectively analyze this data.

Author : Stella Tartsinis, DMA
Publisher : Stella Tartsinis
ISBN 13 :
Total Pages : 42 pages
Book Rating : 4./5 ( download)

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Download or read book Melody Design Tools written by Stella Tartsinis, DMA and published by Stella Tartsinis. This book was released on 2020-08-12 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: The guide is divided into four melodic composition tools: basic, intermediate, advance and Counterpoint. It is a guide how to write a good melody to include how to add the melody into musical form. There are practical exercises to practice combining melodic devises and examples showing how these compositional techniques are used in melodic writing.

Author : Helder Nakaya
Publisher : Frontiers Media SA
ISBN 13 : 2889661334
Total Pages : 177 pages
Book Rating : 4.36/5 ( download)

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Download or read book User-Friendly Tools Applied to Genetics or Systems Biology written by Helder Nakaya and published by Frontiers Media SA. This book was released on 2020-12-01 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Lin Zhang
Publisher : Springer
ISBN 13 : 9811026661
Total Pages : 709 pages
Book Rating : 4.69/5 ( download)

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Download or read book Theory, Methodology, Tools and Applications for Modeling and Simulation of Complex Systems written by Lin Zhang and published by Springer. This book was released on 2016-09-21 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: This four-volume set (CCIS 643, 644, 645, 646) constitutes the refereed proceedings of the 16th Asia Simulation Conference and the First Autumn Simulation Multi-Conference, AsiaSim / SCS AutumnSim 2016, held in Beijing, China, in October 2016. The 265 revised full papers presented were carefully reviewed and selected from 651 submissions. The papers in this second volume of the set are organized in topical sections on HMI and robot simulations; modeling and simulation for intelligent manufacturing; military simulation; visualization and virtual reality.

Author : Sylvia E. Thornbush
Publisher : Bentham Science Publishers
ISBN 13 : 9811441243
Total Pages : 297 pages
Book Rating : 4.40/5 ( download)

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Download or read book Changing Landscapes in Urban British Churchyards written by Sylvia E. Thornbush and published by Bentham Science Publishers. This book was released on 2020-04-27 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: his interdisciplinary reference work presents a linked consideration, to the reader, of physical- cultural (physicocultural) representations of headstones located in urban churchyards in England and Scotland. The geomorphology of landscapes relevant to these locations is explained with the help of detailed case studies from Oxford and Edinburgh. The integrated physicocultural approach addresses the conservation of the archaeological record and presents a cross-temporal perspective of landscape change – of the headstones as landforms in their landscape (as part of deathscapes). The physical record (of headstones) is examined in the context of both cultural representation and change. In this way, an integrated approach is employed that connects the physical (natural) and cultural (social) records kept by historians and archeologists over the years. Changing Landscapes in Urban British Churchyards is of interest to geomorphologists, historians and scholars interested in understanding landscaping studies and cultural nuance of specific historical urban sites in England and Scotland.

Author :
Publisher :
ISBN 13 :
Total Pages : 98 pages
Book Rating : 4./5 ( download)

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Download or read book InfoWorld written by and published by . This book was released on 1993-06-14 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: InfoWorld is targeted to Senior IT professionals. Content is segmented into Channels and Topic Centers. InfoWorld also celebrates people, companies, and projects.

Author : David J. Gilmore
Publisher : Springer Science & Business Media
ISBN 13 : 9783540576532
Total Pages : 400 pages
Book Rating : 4.33/5 ( download)

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Download or read book User-Centred Requirements for Software Engineering Environments written by David J. Gilmore and published by Springer Science & Business Media. This book was released on 1994-02-28 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on a NATO Advanced Research Workshop on User-Centred Requirements for Software Engineering Environments held in Bonas, France, in September 1991. The workshop was organized in two halves, one dominated by discussion of usability problems in software engineering and the other by discussion of existing solutions to these problems. The papers in the volume are grouped under four themes: - Design activities and representations for design - Code representation and manipulation - Technological solutions - The impact of design methods and new programming paradigms.

Author : Martin Zacharias
Publisher : World Scientific
ISBN 13 : 1908978546
Total Pages : 400 pages
Book Rating : 4.47/5 ( download)

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Download or read book Protein-Protein Complexes written by Martin Zacharias and published by World Scientific. This book was released on 2010-05-04 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the immense progress achieved in elucidating protein–protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein–protein interactions from the analysis of protein–protein complex structures and interfaces. What are the driving forces for protein–protein association? How can we extract the mechanism of specific recognition from studying protein–protein interfaces? How can this knowledge be used to predict and design protein–protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein–protein interactions, and how can we influence protein–protein interactions by mutagenesis and small-molecule drugs or peptide mimetics? The book consists of about 15 review chapters, written by experts, on the characterization of protein–protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein–protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein–protein complex structures (docking and homology modeling of complexes, etc.) and design of protein–protein interactions. It serves as a bridge between studying/analyzing protein–protein complex structures (interfaces), predicting interactions, and influencing/designing interactions. Contents: X-ray Study of Protein–Protein Complexes and Analysis of Interfaces (J Janin)A Structural Perspective on Protein–Protein Interactions in Macromolecular Assemblies (R P Bahadur)Energetics of Protein–Protein Interactions (I Jelezarov)Kinetics of Biomacromolecular Complex Formation: Theory and Experiment (G V Pachov et al.)Evolutionary Trace of Protein Functional Determinants (O Lichtarge)Protein–Protein Docking (A Saladin & C Prevost)Data-driven Docking: Using External Information to Spark the Biomolecular Rendez-vous (A S J Melquiond & A M J J Bonvin)High-Resolution Protein–Protein Docking (N London & O Schueler-Furman)Scoring and Refinement of Predicted Protein–Protein Complexes (M Zacharias)Motif-medicated Protein Interactions and Their Role in Disease (H Dinkel & H Sticht)Prediction and Calculation of Protein–Protein Binding Affinities and Mutation Effects (S Fiorucci et al.)Small-molecule Inhibitors of Protein–Protein Interactions (T Berg)Protein Dynamics and Drug Design: The Role of Molecular Simulations (G Morra et al.) Readership: Graduate students and researchers in bioinformatics and computational biology, biophysics, biochemistry, structural biology, and drug design. Keywords:Protein–Protein Interactions;Protein–Protein Complexes;Protein Design;Binding Interface, Protein Evolution;Structural Bioinformatics;Protein Interaction NetworkKey Features:Covers protein–protein interactions at the structural level in great detailDescribes the structure of protein–protein complexes, and also gives insight into the mechanism of complex formation and the forces that drive complex formationCovers to some degree the emerging field of designing new protein–protein interactions, i.e. how to interfere with protein–protein interactions that are of medical importance through drug design

Author : Michael R. Barnes
Publisher : John Wiley & Sons
ISBN 13 : 0470026197
Total Pages : 577 pages
Book Rating : 4.99/5 ( download)

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Download or read book Bioinformatics for Geneticists written by Michael R. Barnes and published by John Wiley & Sons. This book was released on 2007-04-16 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise from the reviews: "Without reservation, I endorse this text as the best resource I've encountered that neatly introduces and summarizes many points I've learned through years of experience. The gems of truth found in this book will serve well those who wish to apply bioinformatics in their daily work, as well as help them advise others in this capacity." CIRCGENETICS "This book may really help to get geneticists and bioinformaticians on 'speaking-terms'... contains some essential reading for almost any person working in the field of molecular genetics." EUROPEAN JOURNAL OF HUMAN GENETICS "... an excellent resource... this book should ensure that any researcher's skill base is maintained." GENETICAL RESEARCH “… one of the best available and most accessible texts on bioinformatics and genetics in the postgenome age… The writing is clear, with succinct subsections within each chapter….Without reservation, I endorse this text as the best resource I’ve encountered that neatly introduces and summarizes many points I’ve learned through years of experience. The gems of truth found in this book will serve well those who wish to apply bioinformatics in their daily work, as well as help them advise others in this capacity.” CIRCULATION: CARDIOVASCULAR GENETICS A fully revised version of the successful First Edition, this one-stop reference book enables all geneticists to improve the efficiency of their research. The study of human genetics is moving into a challenging new era. New technologies and data resources such as the HapMap are enabling genome-wide studies, which could potentially identify most common genetic determinants of human health, disease and drug response. With these tremendous new data resources at hand, more than ever care is required in their use. Faced with the sheer volume of genetics and genomic data, bioinformatics is essential to avoid drowning true signal in noise. Considering these challenges, Bioinformatics for Geneticists, Second Edition works at multiple levels: firstly, for the occasional user who simply wants to extract or analyse specific data; secondly, at the level of the advanced user providing explanations of how and why a tool works and how it can be used to greatest effect. Finally experts from fields allied to genetics give insight into the best genomics tools and data to enhance a genetic experiment. Hallmark Features of the Second Edition: Illustrates the value of bioinformatics as a constantly evolving avenue into novel approaches to study genetics The only book specifically addressing the bioinformatics needs of geneticists More than 50% of chapters are completely new contributions Dramatically revised content in core areas of gene and genomic characterisation, pathway analysis, SNP functional analysis and statistical genetics Focused on freely available tools and web-based approaches to bioinformatics analysis, suitable for novices and experienced researchers alike Bioinformatics for Geneticists, Second Edition describes the key bioinformatics and genetic analysis processes that are needed to identify human genetic determinants. The book is based upon the combined practical experience of domain experts from academic and industrial research environments and is of interest to a broad audience, including students, researchers and clinicians working in the human genetics domain.