Molecular Signaling In Spermatogenesis And Male Infertility

Author : Rajender Singh
Publisher : CRC Press
ISBN 13 : 0429534426
Total Pages : 338 pages
Book Rating : 4.23/5 ( download)

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Download or read book Molecular Signaling in Spermatogenesis and Male Infertility written by Rajender Singh and published by CRC Press. This book was released on 2019-11-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successful spermatogenesis Covers comprehensive information about Spermatogenesis at one place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell development and fertility Highlights the translational opportunities in molecular signaling in testis

Author : C.Yan Cheng
Publisher : Springer Nature
ISBN 13 : 3030777790
Total Pages : 323 pages
Book Rating : 4.91/5 ( download)

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Download or read book Molecular Mechanisms in Spermatogenesis written by C.Yan Cheng and published by Springer Nature. This book was released on 2021-08-28 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition provides an update on the molecular mechanisms that regulate spermatogenesis. In addition to the rodent as a study model, chapters also include research on studies in humans. It includes the latest approaches of studying spermatogenesis, such as the use of bioinformatics, molecular modeling and others which are not commonly found in published materials. It also reviews the latest developments in the field, such as studies on the role of regulatory RNAs on spermatogenesis. Due to the declining fertility rate among men, a brand new chapter highlights the impact of environmental toxicants on spermatogenesis.

Author : Xiang Xiao
Publisher : Frontiers Media SA
ISBN 13 : 2832551459
Total Pages : 128 pages
Book Rating : 4.55/5 ( download)

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Download or read book Analyzing Male Reproductive Risk, Understanding Molecular Targets, and Developing Treatments written by Xiang Xiao and published by Frontiers Media SA. This book was released on 2024-07-10 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Male fertility, both resilient and fragile, is heavily affected by external factors such as the environment, drug use, and eating habits, in a similar way to a wall of stone that is constantly attacked and weathered to varying degrees. The use of cancer drugs, for instance, may increase life expectancy and cure diseases, but may also negatively affect male fertility. A variety of factors complicate male infertility, such as the intricate spermatogenesis process. The available methods for diagnosis are limited, not to mention treatment. However, some evidence showed that different reproductive physiologies may share some biological basis and thus molecular pathways, such as mTOR, which plays a role in testis physiology, Sertoli cell function, transcriptional and translational control of spermatogenesis, as well as drug and environmental exposure. Moreover, male fertility can also reflect men's overall health and the likelihood of suffering from certain diseases, suggesting that these events have common regulatory mechanisms. This Research Topic aims to identify these potential shared mechanisms, analyze and explore how environment, disease, drug use, and nutritional supplements affect male fertility, as well as reveal the seemingly chaotic but traceable phenomena. It will be crucial for the development of diagnostics, treatments, and maintenance methods needed to enhance male fertility, which is also the objective of this research topic. This Research Topic encourages Original Research, Reviews, and other accepted article types, including, but not limited to: • Analyses of the possible effects of environmental pollutants brought about by industry and human activities, such as endocrine-disrupting chemicals (EDCs), on male reproduction; • Links between men's overall health and fertility, as well as andrological effects of various illnesses, including infectious diseases, deficiencies, hereditary diseases, and physiological disorders; • Effects of medications and dietary supplements on male reproductive systems, such as those used for cancer treatment, psychiatric disorders, diabetes, etc; • The use of herbal and medicinal remedies to prevent or reverse adverse andrological effects caused by putative toxic chemicals and diseases; • Specific molecular mechanisms and signalling pathways that affect spermatogenesis, the testis, and sperm function associated with the above 4 points; • Shared molecular mechanisms underlying both the generation and remission of male infertility disease.

Author : Kavindra Kumar Kesari
Publisher : Springer Nature
ISBN 13 : 3030893405
Total Pages : 384 pages
Book Rating : 4.08/5 ( download)

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Download or read book Oxidative Stress and Toxicity in Reproductive Biology and Medicine written by Kavindra Kumar Kesari and published by Springer Nature. This book was released on 2022-05-31 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the role of oxidative stress in human reproduction with a focus on men’s health. The physiological roles of reactive oxygen species (ROS) in male fertility are the focus in this book. This topic is important because oxidative stress is a result of the imbalance between ROS and antioxidants in the body which may lead to sperm damage (DNA or count), deformity, and eventually, male infertility. Therefore, for a better understanding of the molecular mechanisms related to male genotoxicity and its regulation in infertility, this book provides an up-to-date view on the impact of oxidative stress factors in male reproduction . The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of ROS or oxidative stress in physiological and pathological states in relation to (in)fertility in the male. This book presents various state-of-the-art chapters of the recent progress in the field of cellular toxicology and clinical manifestations of various issues related to men’s health and fertility. Topics include cell signaling, DNA damage and infertility, the pathophysiology of disease instigation and distribution, immune toxicity and prevention.

Author : Erwin Goldberg
Publisher : Springer
ISBN 13 :
Total Pages : 316 pages
Book Rating : 4.35/5 ( download)

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Download or read book The Testis written by Erwin Goldberg and published by Springer. This book was released on 2000-08-04 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the XVth North American Testis Workshop, held in Louisville, Kentucky, April 7 to 10, 1999, to describe current advances in testis biology. The first two chapters provide a useful historical perspective of testis physiology and formulate compelling research questions about important aspects of sperm formation and function. This prologue sets the scene for the remainder of the volume that follows a logical progression, as the title implies, from stem cell to cell function, but that is necessarily preceded by sex determination, the quintessential requirement for there being a testis in the first place. The program for this XVth Testis Workshop evolved from recommenda tions of the scientific committee and their advice on the selection of invited speakers. The XVth Testis Workshop has a strong comparative flavor with contributions on worms (Caenorhabditis), flies (Drosophila), and chickens, which are models that permit and thereby reveal the power of genetic analy ses of the molecular mechanisms involved in spermatogenesis. A glimpse into the future is provided with information from EST, protein, and genome databases that already have an impact on progress in our understanding of the male germ cell. Although there is heavy emphasis in these chapters on cellular and molecular e,¥ents, database mining and translational profiling relevant to testis function and dysfunction and assisted reproduction tech nologies are not overlooked.

Author : Douglas T. Carrell
Publisher : Springer Science & Business Media
ISBN 13 : 1597451762
Total Pages : 337 pages
Book Rating : 4.65/5 ( download)

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Download or read book The Genetics of Male Infertility written by Douglas T. Carrell and published by Springer Science & Business Media. This book was released on 2007-11-08 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. New tools discussed are discussed. This book therefore serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

Author : Larry I. Lipshultz
Publisher : Cambridge University Press
ISBN 13 : 1139483242
Total Pages : 691 pages
Book Rating : 4.47/5 ( download)

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Download or read book Infertility in the Male written by Larry I. Lipshultz and published by Cambridge University Press. This book was released on 2009-09-24 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this canonical text on male reproductive medicine will cement the book's market-leading position. Practitioners across many specialties - including urologists, gynecologists, reproductive endocrinologists, medical endocrinologists and many in internal medicine and family practice – will see men with suboptimal fertility and reproductive problems. The book provides an excellent source of timely, well-considered information for those training in this young and rapidly evolving field. While several recent books provide targeted 'cookbooks' for those in a male reproductive laboratory, or quick reference for practising generalists, the modern, comprehensive reference providing both a background for male reproductive medicine as well as clinical practice information based on that foundation has been lacking until now. The book has been extensively revised with a particular focus on modern molecular medicine. Appropriate therapeutic interventions are highlighted throughout.

Author : P.H. Vogt
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318060984
Total Pages : 178 pages
Book Rating : 4.80/5 ( download)

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Download or read book Genetics of Human Infertility written by P.H. Vogt and published by Karger Medical and Scientific Publishers. This book was released on 2017-09-12 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.

Author : José A. Horcajadas
Publisher : Academic Press
ISBN 13 : 0128126760
Total Pages : 425 pages
Book Rating : 4.69/5 ( download)

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Download or read book Reproductomics written by José A. Horcajadas and published by Academic Press. This book was released on 2018-07-23 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The –Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine. Thoroughly discusses how genomics and other omics approaches aid clinicians in various areas of reproductive medicine Identifies specific genomic and molecular factors of translational value in treating infertility and analyzing patient data Features chapter contributions by leading international experts

Author : Manuela Simoni
Publisher : Springer
ISBN 13 : 9783319444406
Total Pages : 1364 pages
Book Rating : 4.09/5 ( download)

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Download or read book Endocrinology of the Testis and Male Reproduction written by Manuela Simoni and published by Springer. This book was released on 2017-09-18 with total page 1364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of endocrinology of the male reproductive system, explaining how it works and how, sometimes, it fails to work. World-class specialists present state of the art knowledge on all aspects, including anatomy, physiology, molecular biology, genetics, pathophysiology, clinical manifestations of testicular diseases, endocrine aspects of andrological and sexual diseases, and therapy. Extensive consideration is given to sexual development, testicular function, the clinical approach to disorders of male reproduction, male hypogonadism, sexual dysfunction, and male infertility. In addition, sociodemographic, psychological, and ethical aspects of male reproductive disorders are discussed. The book is intended as a major reference for endocrinologists, andrologists, and sexologists, as well as basic and clinical scientists. It is published as part of the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.