Molecular Mechanisms And Therapies Of Colorectal Cancer 20

Author : Shilpa S. Dhar
Publisher : Frontiers Media SA
ISBN 13 : 2832506410
Total Pages : 201 pages
Book Rating : 4.17/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Mechanisms and Targeted Therapies for Colorectal Cancer written by Shilpa S. Dhar and published by Frontiers Media SA. This book was released on 2022-11-18 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Donatella Delle Cave
Publisher :
ISBN 13 : 9783036565460
Total Pages : 0 pages
Book Rating : 4.69/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Mechanisms and Therapies of Colorectal Cancer written by Donatella Delle Cave and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Donatella Delle Cave
Publisher :
ISBN 13 : 9783725809516
Total Pages : 0 pages
Book Rating : 4.18/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Mechanisms and Therapies of Colorectal Cancer 2.0 written by Donatella Delle Cave and published by . This book was released on 2024-05-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer (CRC) is currently the third leading cause of cancer-related mortality. Transforming growth factor beta (TGF-β) signaling has been associated with CRC growth and metastasis due to its involvement in proliferation, epithelial-to-mesenchymal transition (EMT), and angiogenesis. The TGF-β superfamily contains over forty members, including TGF-βs, Nodal, Activin, and bone morphogenetic proteins (BMPs). Three types of TGF-β receptors (TGFβRs) have been identified: types 1, 2, and 3. After ligand binding, TGF-βR2 recruits and phosphorylates TGF-βR1, which, in turn, phosphorylates downstream SMAD (small mother against decapentaplegic) proteins. Phosphorylated SMAD4 translocates into the nucleus, where it activates the transcription of numerous target genes (including SERPINE1, LTBP2, CDKN1A, ARID3B, ATXN1, PTPRK, RAB6A, SMAD7, EHBP1, etc.), acting predominantly as a tumor suppressor gene. Interestingly, alterations in SMAD4 are frequent in metastatic CRC and, together with TGF-βR2 gene mutations, have been reported as late events able to promote CRC progression. The study of the TGF-β pathway in metastatic CRC is challenging because of the great genetic heterogeneity of CRC. However, the increasing availability of targeted and whole-exome DNA sequencing techniques makes it possible to identify genetic mutations in complex, dynamic, and heterogeneous clinical contexts and make correlations with clinical outcomes.

Author : Ruowen Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2889743977
Total Pages : 512 pages
Book Rating : 4.71/5 ( download)

DOWNLOAD NOW!

Download or read book Advances in the Molecular Mechanisms in Gastrointestinal Tumorigenesis and Treatment written by Ruowen Zhang and published by Frontiers Media SA. This book was released on 2022-02-16 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Chi Hin Cho
Publisher : Academic Press
ISBN 13 : 0128199385
Total Pages : 242 pages
Book Rating : 4.81/5 ( download)

DOWNLOAD NOW!

Download or read book Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies written by Chi Hin Cho and published by Academic Press. This book was released on 2020-05-24 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

Author : W. Schmiegel
Publisher : Springer
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.77/5 ( download)

DOWNLOAD NOW!

Download or read book Colorectal Cancer: Molecular Mechanisms, Premalignant State and Its Prevention written by W. Schmiegel and published by Springer. This book was released on 1999-04-30 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer is one of the most common causes of tumour-associated death in Western countries, and its incidence has been increasing in recent decades. The most important determinant for the course of the disease is tumour stage at the time of diagnosis. The detection of molecular changes in tumour tissue and in benign adenomatous polyps has improved our knowledge of colorectal carcinogenesis. Diseases with a high risk for malignant transformation, as well as family predisposition as an independent risk factor, have been identified. Furthermore, dietary and environmental factors, together with the intake of aspirin and other NSAIDs, influence tumor development. This implies new ways of specific testing for early diagnosis and new prevention strategies based on endoscopy and drug therapy. The main topics of this book, the proceedings of the international Falk Symposium No. 109, held in Titisee, Germany, on October 14-15, 1998, are molecular mechanisms, premalignant state and prevention. State-of-the-art chapters deliver the latest scientific developments on every topic, followed by more detailed chapters on specific items.

Author : Kevin M. Haigis, Ph.D.
Publisher : Springer Science & Business Media
ISBN 13 : 146148412X
Total Pages : 319 pages
Book Rating : 4.27/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Pathogenesis of Colorectal Cancer written by Kevin M. Haigis, Ph.D. and published by Springer Science & Business Media. This book was released on 2013-10-02 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.

Author : Dora M. Velázquez
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.02/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Mechanisms Involved in the Acquisition of Resistance to Treatment of Colon Cancer Cells written by Dora M. Velázquez and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cells are remarkably resilient to therapies aimed at their elimination. The exploration of pathways that sustain cancer cells and that allow cancer cells to become resistant has revealed new avenues for chemotherapeutic development, as well as rational approaches to combination therapies based on existing treatment options. Several signaling pathways, such as Wnt, phosphoinositide 3-kinase (PI3K), and Ras-Raf-MEK, constitute integrated networks that work together to maintain cellular homeostasis under basal conditions and to drive cell-mass accumulation and cell cycle progression in the presence of appropriate mitogenic stimuli. During cancer development, these pathways are corrupted in malignant cells to maintain viability and proliferative activity under environmentally stressful conditions such as limited growth factors, oxygen, and nutrients that drive normal cells into quiescence or death. Importantly, dysfunction within any one of these pathways results in compensatory responses from the other networks. Thus, biological research is gradually shifting toward more general approaches that target entire pathways rather than isolated components and integrate those pathways into biological networks.

Author : Jindong Chen
Publisher : BoD – Books on Demand
ISBN 13 : 1789231000
Total Pages : 130 pages
Book Rating : 4.07/5 ( download)

DOWNLOAD NOW!

Download or read book Colorectal Cancer written by Jindong Chen and published by BoD – Books on Demand. This book was released on 2018-05-16 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: With international experts sharing their experience and knowledge on these different aspects in the management of colorectal cancer, this book has this opportunity to offer all physicians treating colorectal cancer, as well as researchers, updated information concerning the biology, diagnosis, screening, and treatment of colorectal carcinoma. This book provides a detailed evaluation of diagnostic modalities, in-depth analysis of screening for colorectal cancer, recent advances in treatment, and principles and trends in the management of colorectal cancer. This updated knowledge will be an interesting and informative read for any clinician involved in the management of patients with colorectal cancer. In addition, readers such as related physicians, researchers, and colorectal cancer patients are potential beneficiaries of this book.

Author : M.C. Langheinrich
Publisher :
ISBN 13 : 9789535100621
Total Pages : pages
Book Rating : 4.29/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Mechanisms of Lymphatic Metastasis written by M.C. Langheinrich and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: