Molecular Mechanisms And Targeted Therapies For Colorectal Cancer

Author : Shilpa S. Dhar
Publisher : Frontiers Media SA
ISBN 13 : 2832506410
Total Pages : 201 pages
Book Rating : 4.17/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Mechanisms and Targeted Therapies for Colorectal Cancer written by Shilpa S. Dhar and published by Frontiers Media SA. This book was released on 2022-11-18 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Benjamin Bonavida
Publisher : Springer Science & Business Media
ISBN 13 : 1461470706
Total Pages : 271 pages
Book Rating : 4.00/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy written by Benjamin Bonavida and published by Springer Science & Business Media. This book was released on 2013-07-04 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​​​​​This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors and such new drugs may either be selective or common to various cancers. If successful, new drugs may not be toxic and may be used effectively in combination with subtoxic conventional drugs to achieve synergy and to reverse tumor cell resistance. The research developments presented in this book can be translated to produce better clinical responses to resistant tumors.

Author : Donatella Delle Cave
Publisher : Mdpi AG
ISBN 13 : 9783036565477
Total Pages : 0 pages
Book Rating : 4.77/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Mechanisms and Therapies of Colorectal Cancer written by Donatella Delle Cave and published by Mdpi AG. This book was released on 2023-01-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer (CRC) is currently the third leading cause of cancer-related mortality, with 1.9 million incidence cases and 0.9 million deaths worldwide. The global number of new CRC cases is predicted to reach 3.2 million in 2040, based on the projection of aging, population growth, and human development. In clinics, despite advances of diagnosis and surgical procedures, 20% of the patients with CRC present with metastasis at the time of diagnosis, caused by residual tumor cells that have spread to distant organs prior to surgery, affecting the patient survival rate. Standard systemic chemotherapy, alternative therapies that target mechanisms involved in cancer progression and metastasis, immunotherapy, and combination therapies are the major CRC-treatment strategies. In the advanced stage of CRC the transforming growth factor-beta (TGF-β) plays an oncogenic role by promoting cancer cell proliferation, cancer cell self-renewal, epithelial-to-mesenchymal transition, invasion, tumor progression, metastatic spread, and immune escape. Furthermore, high levels of TGF-β1 confers poor prognosis and is associated with early recurrence after surgery, resistance to chemo- or immunotherapy, and shorter survival. Based on the body of experimental evidence indicating that TGF-β signaling has the potential to be a good therapeutic target in CRC, several anti-TGF-β drugs have been investigated in cancer clinical trials. Here, we presented a comprehensive collection of manuscripts regarding studies on targeting the TGF-β signaling in CRC to improve patient's prognosis and personalized treatments.

Author : Chi Hin Cho
Publisher : Academic Press
ISBN 13 : 0128199385
Total Pages : 242 pages
Book Rating : 4.81/5 ( download)

DOWNLOAD NOW!

Download or read book Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies written by Chi Hin Cho and published by Academic Press. This book was released on 2020-05-24 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

Author : Ruowen Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2889743977
Total Pages : 512 pages
Book Rating : 4.71/5 ( download)

DOWNLOAD NOW!

Download or read book Advances in the Molecular Mechanisms in Gastrointestinal Tumorigenesis and Treatment written by Ruowen Zhang and published by Frontiers Media SA. This book was released on 2022-02-16 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Donatella Delle Cave
Publisher :
ISBN 13 : 9783725809516
Total Pages : 0 pages
Book Rating : 4.18/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Mechanisms and Therapies of Colorectal Cancer 2.0 written by Donatella Delle Cave and published by . This book was released on 2024-05-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer (CRC) is currently the third leading cause of cancer-related mortality. Transforming growth factor beta (TGF-β) signaling has been associated with CRC growth and metastasis due to its involvement in proliferation, epithelial-to-mesenchymal transition (EMT), and angiogenesis. The TGF-β superfamily contains over forty members, including TGF-βs, Nodal, Activin, and bone morphogenetic proteins (BMPs). Three types of TGF-β receptors (TGFβRs) have been identified: types 1, 2, and 3. After ligand binding, TGF-βR2 recruits and phosphorylates TGF-βR1, which, in turn, phosphorylates downstream SMAD (small mother against decapentaplegic) proteins. Phosphorylated SMAD4 translocates into the nucleus, where it activates the transcription of numerous target genes (including SERPINE1, LTBP2, CDKN1A, ARID3B, ATXN1, PTPRK, RAB6A, SMAD7, EHBP1, etc.), acting predominantly as a tumor suppressor gene. Interestingly, alterations in SMAD4 are frequent in metastatic CRC and, together with TGF-βR2 gene mutations, have been reported as late events able to promote CRC progression. The study of the TGF-β pathway in metastatic CRC is challenging because of the great genetic heterogeneity of CRC. However, the increasing availability of targeted and whole-exome DNA sequencing techniques makes it possible to identify genetic mutations in complex, dynamic, and heterogeneous clinical contexts and make correlations with clinical outcomes.

Author : Kevin M. Haigis, Ph.D.
Publisher : Springer Science & Business Media
ISBN 13 : 146148412X
Total Pages : 319 pages
Book Rating : 4.27/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Pathogenesis of Colorectal Cancer written by Kevin M. Haigis, Ph.D. and published by Springer Science & Business Media. This book was released on 2013-10-02 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.

Author : Francis S. Markland
Publisher : John Wiley & Sons
ISBN 13 : 3527320911
Total Pages : 353 pages
Book Rating : 4.12/5 ( download)

DOWNLOAD NOW!

Download or read book Tumor Angiogenesis written by Francis S. Markland and published by John Wiley & Sons. This book was released on 2010-06-08 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Themen dieses Bandes sind die molekularen Mechanismen der Tumor-Angiogenese, die Suche nach einschlägigen Targets für die Wirkstoffforschung und die Entwicklung von Kombinationstherapien mit bereits existierenden Ansätzen. Die ideale Informationsquelle für Studenten, Ärzte und Forscher in der Pharmaindustrie!

Author : Georg F. Weber
Publisher : Springer Science & Business Media
ISBN 13 : 1402060165
Total Pages : 643 pages
Book Rating : 4.68/5 ( download)

DOWNLOAD NOW!

Download or read book Molecular Mechanisms of Cancer written by Georg F. Weber and published by Springer Science & Business Media. This book was released on 2007-09-12 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.

Author : Daniel Gioeli
Publisher : Springer Science & Business Media
ISBN 13 : 1607614782
Total Pages : 211 pages
Book Rating : 4.84/5 ( download)

DOWNLOAD NOW!

Download or read book Targeted Therapies written by Daniel Gioeli and published by Springer Science & Business Media. This book was released on 2011-06-02 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.