Molecular Mechanisms And Signaling In Endothelial Cell Biology And Vascular Heterogeneity

Author : Bin Ren
Publisher : Frontiers Media SA
ISBN 13 : 2889742520
Total Pages : 332 pages
Book Rating : 4.23/5 ( download)

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Download or read book Molecular Mechanisms and Signaling in Endothelial Cell Biology and Vascular Heterogeneity written by Bin Ren and published by Frontiers Media SA. This book was released on 2022-02-02 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Mirko HH Schmidt
Publisher : Springer
ISBN 13 : 1493929070
Total Pages : 401 pages
Book Rating : 4.78/5 ( download)

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Download or read book Endothelial Signaling in Development and Disease written by Mirko HH Schmidt and published by Springer. This book was released on 2015-10-08 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies. The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research. Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.

Author : Józef Dulak
Publisher : Springer Science & Business Media
ISBN 13 : 3709114284
Total Pages : 414 pages
Book Rating : 4.85/5 ( download)

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Download or read book Angiogenesis and Vascularisation written by Józef Dulak and published by Springer Science & Business Media. This book was released on 2014-02-10 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents the overview of the current knowledge in some fields of vascular biology, addressing cellular and molecular aspects of blood-vessel formation and their role in health and disease. The major factors involved in the formation of blood vessels are presented by scientists actively involved in this area of research. Special emphasis is put on the presentation of various molecular mechanisms not addressed in similar works to date. The book is divided into three parts. The first part describes the cells and mediators in angiogenesis. The significance of various populations of potential endothelial progenitors is particularly highlighted. The chapters of the second part focus on molecular mechanisms, with special emphasis on the role of hypoxia, gasotransmitters and reactive oxygen species as well as microRNAs in regulation of angiogenic processes. In the third part, the pathological aspects of disturbed – aggravated or impaired – vascularization are discussed and new modalities for potential therapies are presented. The book is intended for scientists and PhD students in the fields of vascular biology and cancer research. It may be of interest for medical professionals in the fields of cardiovascular disease, diabetes, oncology and rheumatoid arthritis.

Author : Jean-Jacques Feige
Publisher : Springer
ISBN 13 : 281780466X
Total Pages : 501 pages
Book Rating : 4.68/5 ( download)

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Download or read book Molecular Mechanisms of Angiogenesis written by Jean-Jacques Feige and published by Springer. This book was released on 2014-05-27 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.

Author : Gabor M. Rubanyi
Publisher : CRC Press
ISBN 13 : 0203166477
Total Pages : 488 pages
Book Rating : 4.75/5 ( download)

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Download or read book Vascular Protection written by Gabor M. Rubanyi and published by CRC Press. This book was released on 2002-02-21 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular Protection explores advances in vascular biology and how they translate into innovations in drug therapy for vascular disease. It addresses recent advances in the knowledge of endothelial vasoactive factors and other biologically active molecules as well as gene therapy. Written by leading experts in their respective fields, each chapter e

Author : Eric A. Jaffe
Publisher : Springer Science & Business Media
ISBN 13 : 146132825X
Total Pages : 471 pages
Book Rating : 4.54/5 ( download)

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Download or read book Biology of Endothelial Cells written by Eric A. Jaffe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: The participation of endothelial cells in various physiologic and pathologic processes has been hypothesized since before the turn of the century. However, until recently, direct evidence for endothelial involvement in these processes has been extremely difficult to obtain due to the inability to study endothelial cell function in vitro. Though the possibility of using cultured endothelial cells to study endothelial cell function in vitro was recognized many years ago, the inability to culture unambiguously identifiable endothelial cells limited investigators in their studies of endothelial function. As a result, the field of endothelial cell biology lay relatively fallow for many years. The development in the early 1970's of routine and easily implemented methods for culturing human endothelial cells and the demonstration that cultured endothelial cells synthesized a physiologically relevant protein, Factor VIII/von Willebrand Factor, quickly changed this state of affairs. Over the following decade the scope of endothelial cell research rapidly widened, spreading in a number of directions. First, methods were developed to culture endothelial cells from a variety of species. Second, methods were developed to culture endothelial cells from different organs and types of blood vessels (arteries, veins, and capillaries) within a single species. Third, and most important, investigators began using cultured endothelial cells as tools to study the potential involvement of endothelial cells in a wide assortment of biologically interesting processes. The net result has been a tremendous increase in our understanding of endothelial cell function.

Author : Sarah Y. Yuan
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041206
Total Pages : 159 pages
Book Rating : 4.06/5 ( download)

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Download or read book Regulation of Endothelial Barrier Function written by Sarah Y. Yuan and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the vascular wall and surrounding extravascular tissues. In addition to regulating blood delivery and perfusion, a major function of vascular endothelia, especially those in exchange microvessels (capillaries and postcapillary venules), is to provide a semipermeable barrier that controls blood-tissue exchange of fluids, nutrients, and metabolic wastes while preventing pathogens or harmful materials in the circulation from entering into tissues. During host defense against infection or tissue injury, endothelial barrier dysfunction occurs as a consequence as well as cause of inflammatory responses. Plasma leakage disturbs fluid homeostasis and impairs tissue oxygenation, a pathophysiological process contributing to multiple organ dysfunction associated with trauma, infection, metabolic disorder, and other forms of disease. In this book, we provide an updated overview of microvascular endothelial barrier structure and function in health and disease. The discussion is initiated with the basic physiological principles of fluid and solute transport across microvascular endothelium, followed by detailed information on endothelial cell-cell and cell-matrix interactions and the experimental techniques that are employed to measure endothelial permeability. Further discussion focuses on the signaling and molecular mechanisms of endothelial barrier responses to various stimulations or drugs, as well as their relevance to several common clinical conditions. Taken together, this book provides a comprehensive analysis of microvascular endothelial cell and molecular pathophysiology. Such information will assist scientists and clinicians in advanced basic and clinical research for improved health care. Table of Contents: Acknowledgments / Introduction / Structure and Function of Exchange Microvessels / Methods for Measuring Permeability / The Endothelial Barrier / Signaling Mechanisms in the Regulation of Endothelial Permeability / Endothelial Barrier Protectors / Pathophysiology and Clinical Relevance / Conclusion / References

Author : John D. Catravas
Publisher :
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.28/5 ( download)

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Download or read book Vascular Endothelium written by John D. Catravas and published by . This book was released on 1999 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Mark Slevin
Publisher : Springer Science & Business Media
ISBN 13 : 9048194954
Total Pages : 438 pages
Book Rating : 4.57/5 ( download)

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Download or read book Therapeutic Angiogenesis for Vascular Diseases written by Mark Slevin and published by Springer Science & Business Media. This book was released on 2010-10-11 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis is the growth of new blood vessels and is a key process which occurs during pathological disease progression. Excessive and damaging angiogenesis occurs in diseases such as cancer, diabetic retinopathies, age-related macular degeneration and atherosclerosis. In other diseases such as stroke and myocardial infarction, insufficient or improper angiogenesis results in tissue loss and ultimately higher morbidity and mortality. In this book we will begin by providing the reader with an overview of the process of angiogenesis including normal embryological development of blood vessels. The following chapters will each focus on a key angiogenic disease incorporating current scientific knowledge concerning the causes of activation of the “angiogenic switch”, pathological consequences, current treatment options and future perspectives. Where appropriate, results from pre-clinical trials, novel imaging modalities and nanotechnological approaches will be incorporated into these sections. Finally, since it is now believed that the process of angiogenesis operated via different signalling mechanisms in different vascular beds, we will discuss our current understanding of this phenomenon. The target audience for this book would include researchers in all the basic sciences; post-graduate students at Universities and Institutes; pharmaceutical industries; clinicians working in vascular biology or tissue imaging; pathologists; neurologists; tumour biologists; ophthalmologists and cardiologists.

Author : Marcelo González
Publisher : BoD – Books on Demand
ISBN 13 : 1839690356
Total Pages : 230 pages
Book Rating : 4.58/5 ( download)

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Download or read book Vascular Biology written by Marcelo González and published by BoD – Books on Demand. This book was released on 2020-11-11 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two main causes of death in the world are directly related to cardiovascular system disorders, ischemic heart disease, and stroke. These pathological conditions are caused by complex molecular mechanisms related to endothelial dysfunction and, finally, structural and functional alterations of blood vessels. Clinical evidence demonstrates the relevance of knowledge about vascular biology, from molecular mechanisms to clinical applications, especially for students of medical sciences or basic sciences. This book is an international effort of collaboration, with the purpose to create an academic tool for students or people interested in learning about vascular biology. I invite the readers to check the chapters and explore the topics developed by experts in the field.