Molecular Diagnostics In Cancer Patients

Author : Kamla Kant Shukla
Publisher : Springer
ISBN 13 : 981135877X
Total Pages : 341 pages
Book Rating : 4.77/5 ( download)

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Download or read book Molecular Diagnostics in Cancer Patients written by Kamla Kant Shukla and published by Springer. This book was released on 2019-03-15 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.

Author : Joseph E. Roulston
Publisher : Springer Science & Business Media
ISBN 13 : 1592597602
Total Pages : 389 pages
Book Rating : 4.04/5 ( download)

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Download or read book Molecular Diagnosis of Cancer written by Joseph E. Roulston and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are currently experiencing a fundamental shift in the way in which we approach the characterization of cancer. Never before has the make up of cancer tissues and individual cells been so exhaustively researched and char- terized. We are now capable of producing molecular “fingerprints” that ch- acterize the expression of all known and unknown genes within tumors and their surrounding tissues. More than 30,000 different genes may be measured in each patient’s tumor in a single experiment. Simultaneously, novel therapies that exploit the molecular roadmap have been developed and are now being offered to patients. These novel agents, such as Glivec, Herceptin, Iressa, and others, specifically target individual genes within tumors and can produce d- matic responses in some patients. These drugs are only the forerunners of a coming tidal wave of novel therapeutics that individually target specific m- ecules within cancer cells—more than 300 such agents are currently in phase I or II clinical trials. This is an exciting time for cancer specialists and patients alike. However, if we have learned anything from the past 50 or more years of research into cancer, it is that Lord Beaverbrook, in founding the British national health service in the 1950s, was frighteningly prescient when he defined the primary goal of health care to be “Diagnosis, Diagnosis, Diag- sis. ” Now, more than ever, it is essential that appropriate diagnostic methods and approaches are applied to the selection of patients for treatment.

Author : Kamla Kant Shukla
Publisher :
ISBN 13 : 9789811358784
Total Pages : pages
Book Rating : 4.88/5 ( download)

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Download or read book Molecular Diagnostics in Cancer Patients written by Kamla Kant Shukla and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.

Author : Dongfeng Tan
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1469820641
Total Pages : 2177 pages
Book Rating : 4.44/5 ( download)

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Download or read book Principles of Molecular Diagnostics and Personalized Cancer Medicine written by Dongfeng Tan and published by Lippincott Williams & Wilkins. This book was released on 2012-12-07 with total page 2177 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.

Author : Asfar Azmi
Publisher : Elsevier
ISBN 13 : 0124079466
Total Pages : 467 pages
Book Rating : 4.65/5 ( download)

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Download or read book Molecular Diagnostics and Treatment of Pancreatic Cancer written by Asfar Azmi and published by Elsevier. This book was released on 2014-04-14 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas – helping researchers in pancreatic cancer drug discovery Summarizes many relevant computational and clinical references from fast-evolving literature Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

Author : Nader Rifai
Publisher : Elsevier
ISBN 13 : 0128160624
Total Pages : 422 pages
Book Rating : 4.26/5 ( download)

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Download or read book Principles and Applications of Molecular Diagnostics written by Nader Rifai and published by Elsevier. This book was released on 2018-06-13 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Applications of Molecular Diagnostics serves as a comprehensive guide for clinical laboratory professionals applying molecular technology to clinical diagnosis. The first half of the book covers principles and analytical concepts in molecular diagnostics such as genomes and variants, nucleic acids isolation and amplification methods, and measurement techniques, circulating tumor cells, and plasma DNA; the second half presents clinical applications of molecular diagnostics in genetic disease, infectious disease, hematopoietic malignancies, solid tumors, prenatal diagnosis, pharmacogenetics, and identity testing. A thorough yet succinct guide to using molecular testing technology, Principles and Applications of Molecular Diagnostics is an essential resource for laboratory professionals, biologists, chemists, pharmaceutical and biotech researchers, and manufacturers of molecular diagnostics kits and instruments. Explains the principles and tools of molecular biology Describes standard and state-of-the-art molecular techniques for obtaining qualitative and quantitative results Provides a detailed description of current molecular applications used to solve diagnostics tasks

Author : Gary S. Stein
Publisher : John Wiley & Sons
ISBN 13 : 1118962885
Total Pages : 708 pages
Book Rating : 4.86/5 ( download)

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Download or read book Cancer written by Gary S. Stein and published by John Wiley & Sons. This book was released on 2019-09-18 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to recent insights into the genetic and epigenetic parameters of cancer biology and pathology and emerging clinical applications The thoroughly updated second edition of The Biology and Treatment of Cancer, now titled Cancer: Prevention, Early Detection, Treatment and Recovery, goes beyond reviewing the fundamental properties of cancer biology and the relevant issues associated with treatment of the disease. The new edition contains coverage of additional "patient centric" topics and presents cancer biology with selection of topics, facts, and perspectives written in easy-to-understand terms. With contributions from noted experts, the book explores recent advances in the understanding of cancer including breakthroughs in the molecular and cellular basis of cancer and provides strategies for approaching cancer prevention, early detection, and treatment. The authors incorporate recent information on the genetic and epigenetic parameters of cancer biology and pathology with indications of emerging clinical applications. The text offers a unique guide to cancer prevention, early detection, treatment, and recovery for students, caregivers, and most importantly cancer patients. This significant book: Incorporates current insight into the genetic and epigenetic parameters of cancer biology and pathology and information on emerging clinical applications Contains contributions from leaders in cancer research, care, and clinical trials Offers an accessible guide to an accurate and balanced understanding of cancer and the cancer patient Focuses on the importance of cancer prevention, early detection, treatment, and survivorship Written for medical students, students of cancer biology, and caregivers and cancer patients, Cancer: Prevention, Early Detection, Treatment and Recovery offers an authoritative overview of the challenges and opportunities associated with cancer biology, cancer research, and the spectrum of clinical considerations.

Author : Pier Paolo Piccaluga
Publisher : BoD – Books on Demand
ISBN 13 : 1837694346
Total Pages : 286 pages
Book Rating : 4.41/5 ( download)

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Download or read book Molecular Diagnostics of Cancer written by Pier Paolo Piccaluga and published by BoD – Books on Demand. This book was released on 2024-04-10 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision medicine, also known as personalized medicine, is an innovative approach to medical treatment and diagnosis that takes into account individual variability in genes, environment, and lifestyle for each person. In the context of cancer, precision medicine aims to tailor medical care to the specific genetic and molecular characteristics of each patient's tumor. This allows for more targeted and effective treatments, minimizing side effects and improving outcomes. The first step in precision medicine, especially in oncology, is represented by an accurate diagnosis, including molecular and genetic data. A comprehensive assessment in molecular pathology includes conventional and more innovative techniques, including polymerase chain reaction (PCR)-based approaches, Sanger sequencing, and next-generation sequencing for genomic profiling. Precision medicine relies on the analysis of the patient's genomic information, including the DNA mutations present in their tumor. Genomic profiling helps identify specific genetic alterations that are driving the growth of cancer cells. This information is crucial for selecting targeted therapies that directly interfere with these specific molecular abnormalities. In addition, molecular diagnostics provide: • biomarker identification • tumor heterogeneity assessment In turn, this translates into direct treatment decision support. The information obtained through molecular tests guides oncologists in making more informed decisions about the most appropriate treatments for individual patients. This can include targeted therapies, immunotherapies, or other interventions based on the specific molecular profile of the tumor. Prognostication becomes treatment-specific (prediction) and predictive models can be developed by integrating genetic and molecular data with clinical information, to estimate the likelihood of treatment response, recurrence, and overall prognosis. Overall, molecular pathology has significantly advanced cancer diagnostics and treatment, leading to improved outcomes and a shift toward more personalized and effective care. The integration of molecular diagnostics and genomic information has transformed how cancer is understood and managed, offering new hope for patients and providing oncologists with powerful tools to combat the complexity of the disease.

Author : Jing He
Publisher : Frontiers Media SA
ISBN 13 : 2889743004
Total Pages : 192 pages
Book Rating : 4.01/5 ( download)

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Download or read book Molecular Diagnostics of Pediatric Cancer written by Jing He and published by Frontiers Media SA. This book was released on 2022-02-08 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : George P. Patrinos
Publisher : Academic Press
ISBN 13 : 0128029889
Total Pages : 520 pages
Book Rating : 4.86/5 ( download)

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Download or read book Molecular Diagnostics written by George P. Patrinos and published by Academic Press. This book was released on 2016-10-27 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field