Molecular And Cellular Gerontology

Author : Olivier Toussaint
Publisher :
ISBN 13 : 9781573312714
Total Pages : 0 pages
Book Rating : 4.11/5 ( download)

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Download or read book Molecular and Cellular Gerontology written by Olivier Toussaint and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work covers a number of relevant aspects of the molecular and cellular biology of ageing, a timely general topic highlighted by the United Nations' having declared 1999 the Year of the Elderly. The papers published here represent a wide range of complementary research areas: molecular and cellular aspects; theories of ageing; molecular basis of the loss of homeostatic maintenance mechanisms; lower and higher model organisms including transgenic animal models; the genetics of human longevity; clinical and molecular aspects of age-related diseases; and integrated systems like brain and immune system aging. It is hoped that the additions to knowledge of the molecular mechanisms of ageing provided by this volume may ultimately lead to the prevention of age-related diseases.

Author : Leonard Guarente
Publisher : CSHL Press
ISBN 13 : 0879698241
Total Pages : 610 pages
Book Rating : 4.49/5 ( download)

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Download or read book Molecular Biology of Aging written by Leonard Guarente and published by CSHL Press. This book was released on 2008 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.

Author : Thomas von Zglinicki
Publisher : Springer Science & Business Media
ISBN 13 : 9401706670
Total Pages : 249 pages
Book Rating : 4.74/5 ( download)

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Download or read book Aging at the Molecular Level written by Thomas von Zglinicki and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.

Author : A Roy
Publisher : Elsevier
ISBN 13 : 0323151558
Total Pages : 411 pages
Book Rating : 4.59/5 ( download)

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Download or read book Molecular Basis of Aging written by A Roy and published by Elsevier. This book was released on 2012-12-02 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Basis of Aging is a collection of papers that discuss the molecular aspects of aging in the light of molecular biology, biochemical gerontology, and genetics. Each chapter of the book contains a different study about the topic, which includes the effects of aging on DNA synthesis; the amplification of extrachromosomal circular copies and mitochondrial DNA during aging; and the altered actions of hormones and neurotransmitters during aging. The book also encompasses the loss of responsiveness to growth factors in cell senescence; the integration of cellular-molecular and neuroendocrine concepts of aging; changes and inactivation of enzymes during aging; and the relationship of aging with free radicals. The text is recommended for molecular biologists, biochemists, and gerontologists who wish to study further the effects of aging on the body on a molecular level.

Author : Konrad Beyreuther
Publisher : Springer Science & Business Media
ISBN 13 : 3642842240
Total Pages : 327 pages
Book Rating : 4.45/5 ( download)

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Download or read book Molecular Mechanisms of Aging written by Konrad Beyreuther and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Mark P. Mattson
Publisher : Elsevier
ISBN 13 : 9780444518767
Total Pages : 212 pages
Book Rating : 4.62/5 ( download)

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Download or read book Sleep and Aging written by Mark P. Mattson and published by Elsevier. This book was released on 2005-06-20 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sleep and Aging provides a unique and timely collection of review articles that cover the gamut of basic and clinical aspects of sleep and the abnormalities in sleep associated with aging and neurological disorders that occur during aging. From the evolutionary basis of sleep and its normal functions in processes such as learning and memory, to considerations of the roles of sleep abnormalities in neurological disorders such as depression, Alzheimer's and Parkinson's diseases, the chapters are written by experts in the field. Several chapters focus on signalling pathways involved in sleep regulation and abnormalities in sleep, including those activated by serotonin and BDNF. Basic and clinical research on insomnia, sleep apnea and other disorders of sleep, are covered thus providing students and scientists at all levels with a valuable source of information to advance their understanding of this important topic in aging, biology and medicine. The circuits in the brain involved in sleep regulation, their neurochemistry, how they are altered in disorders of sleep and current clinical treatments of various sleep disorders are reviewed. The important role of sleep disturbances in neurodegenerative disorders is described and research in this particular area is leading to a better understanding of the relationships between synaptic plasticity, neuronal degeneration and the clinical manifestations of disorders such as Alzheimer's disease, Parkinson's disease and depression. This book is a must for scientists, as well as non-scientists, who are interested in the neurobiology of aging, sleep and neurodegenerative disorders.

Author : Evandro Fei Fang
Publisher : Academic Press
ISBN 13 : 032391618X
Total Pages : 262 pages
Book Rating : 4.89/5 ( download)

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Download or read book Molecular, Cellular, and Metabolic Fundamentals of Human Aging written by Evandro Fei Fang and published by Academic Press. This book was released on 2022-10-23 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion. The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology. Covers the basic hallmarks of aging and their relevance in various diseases, such as cancer and Alzheimer’s disease Discusses the impact of genetic damage and how changes in genetic expression patterns affect the process of aging Highlights recurring themes and key principles shared across the hallmarks of aging Considers NAD+ depletion and defective autophagy as emerging aspects that impact human aging

Author : S.I. Rattan
Publisher : Springer Science & Business Media
ISBN 13 : 1461558891
Total Pages : 371 pages
Book Rating : 4.97/5 ( download)

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Download or read book Molecular Gerontology written by S.I. Rattan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Esteemed researchers from different European laboratories provide state-of-the-art studies on biology and ageing, along with guidelines for future investigations. They cover such issues in molecular gerontological research as regulation of gene expression from DNA to RNA to functional proteins, origin of various age-associated diseases, genetic regulation of ageing and longevity, and different mechanisms of defense and repair. Other contributions evaluate new technologies, including transgenic organisms, and the use of nutritional and chemical modulators of ageing and lifespan.

Author : Stringer Sue Yang
Publisher : Springer Science & Business Media
ISBN 13 : 1461529263
Total Pages : 336 pages
Book Rating : 4.62/5 ( download)

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Download or read book The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging written by Stringer Sue Yang and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background Cancer is a variety of malignancies generally associated with aging. As the overall health technology and health care delivery improved with the advances made in medicine and science in the United States, the life expectancy of the population also increased. The average life expectancy in the U. S. A. has increased from 49 years at the end of 1900 to 75 years today in 1990 (1-3). The population of 65 years and older that constituted 25. 5 million or 11. 3% of the total U. S. population in 1980(4) has now increased to 31. 1 million or 12. 5% of the population according to the 1990(5) census. As cancer diagnosis and treatment have improved, cancer mortality among patients under 55 has been significantly reduced within recent years *1; however, cancer incidence under 55 is still increasing at about 0. 4% per year (as compared to 1. 0% for all ages or 0. 6% for

Author : Bernard Strihler
Publisher : Academic Press
ISBN 13 :
Total Pages : 510 pages
Book Rating : 4.21/5 ( download)

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Download or read book Times, Cells, and Aging written by Bernard Strihler and published by Academic Press. This book was released on 1977-01-28 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Time, Cells, and Aging, 2nd Edition presents the mechanics of cell function and the relevant implications of the molecular-genetic view to the aging phenomena. This book explores the biology of the aging process. Comprised of 11 chapters, this edition starts with an overview of the causes and mechanisms underlying the gradual deterioration of structure and function characteristics of aging. This text then examines the two aspects of the behavior of man, including the reasoned conscious behavior and the greater dependence on reaction patterns predicted on the successful responses of the past. Other chapters explore the relationship between aging and mortality rate in animals, which is a result of an organism's deceasing ability to function optimally in carrying out his vital functions. The final chapter deals with the implementation of a research plan relevant to understanding the primary mechanisms of the aging process. This book is a valuable resource for gerontologists, biologists, and molecular biologists.