Modulation Of Oxidative Stress In Heart Disease

Author : Sajal Chakraborti
Publisher : Springer Nature
ISBN 13 : 9811389462
Total Pages : 686 pages
Book Rating : 4.67/5 ( download)

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Download or read book Modulation of Oxidative Stress in Heart Disease written by Sajal Chakraborti and published by Springer Nature. This book was released on 2019-11-10 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.

Author : Sajal Chakraborti
Publisher : Springer Nature
ISBN 13 : 9811382735
Total Pages : 596 pages
Book Rating : 4.34/5 ( download)

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Download or read book Oxidative Stress in Heart Diseases written by Sajal Chakraborti and published by Springer Nature. This book was released on 2019-11-06 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Author : Neelam Khaper
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.09/5 ( download)

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Download or read book Modulation of Oxidative Stress and Antioxidants by Losartan in Heart Failure written by Neelam Khaper and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : John F. Keaney Jr.
Publisher : Springer Science & Business Media
ISBN 13 : 9780792386780
Total Pages : 404 pages
Book Rating : 4.87/5 ( download)

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Download or read book Oxidative Stress and Vascular Disease written by John F. Keaney Jr. and published by Springer Science & Business Media. This book was released on 1999-12-31 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.

Author : Mohinder Bansal
Publisher : Springer
ISBN 13 : 8132220323
Total Pages : 183 pages
Book Rating : 4.29/5 ( download)

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Download or read book Oxidative Stress Mechanisms and their Modulation written by Mohinder Bansal and published by Springer. This book was released on 2014-10-17 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research over the years has demonstrated that free radicals mediated oxidative stress lies at the helm of almost all patho-physiological phenomena. These findings emphasize on the need to understand the underlying molecular mechanism(s) and their critical role in the pathogenesis. This book aims to focus on these areas to provide readers a comprehensive outlook about the major redox sensitive pathways and networks involved in various disease conditions. In the first chapter of the book, basic information about the oxidative stress, its generation, its biomarkers and its role in body are discussed. In the next three chapters, the role of oxidative stress in various pathologies ranging from neurological disorders, to cardiovascular diseases, cancers, metabolic diseases and ageing have been described. Chapter 5 cumulatively describes the most important molecular signaling pathways that are affected by reactive oxygen species (ROS). These are the mechanisms which are common denominators in various pathological states. In the next part of the book, various antioxidant strategies to target and mitigate ROS have been discussed with details on the mechanisms. Selenium, being the research focus and interest of the authors for years, the role of selenium as an antioxidant as part of selenoproteins has been included in the book. Finally, the book culminates with authors’ perspective on the future of the redox biology field. Throughout the book, efforts have been made to use simplified language and suitable figures for ease to understand the contents. Although the authors have tried to touch on all the different aspects of oxidative stress in detail, the fact that it is a continuously growing field with updates coming every day, there might be some areas which might not be described in depth. This book is designed for students, young scientists to get acquainted with the redox biology. Overall, this book is a reference to understand the redox regulation of cellular signaling pathways involved in pathogenesis.

Author : Muiruri Macharia
Publisher :
ISBN 13 :
Total Pages : 172 pages
Book Rating : 4.25/5 ( download)

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Download or read book Modulation of Oxidative Stress Biomarkers by Rooibos in Adults at Risk of Developing Coronary Heart Disease written by Muiruri Macharia and published by . This book was released on 2008 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.72/5 ( download)

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Download or read book Modulation of Oxidative Stress and Antioxidants by Losartan in Heart Failure written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In patients surviving a myocardial infarction M), the heart undergoes a remodefing process characterized by hypertrophy which can also lead to heart failure. Although hypertrophy is an early response that may temporarily preserve cardiac function, numerous studies have suggested that this long term process of remodefing is also associated with an increase in oxidative stress and cardiac decompensation. The objectives of the present research on rat hearts subsequent to MI therefore, were to: (i) characterize changes in the oxidative stress and enzymatic antioxidants, (superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and catalase) in relation to their rnRNA abundance and protein content; (ii) study changes in nonenzymatic antioxidants at different stages of heart failure in relation to cardiac function in order to have a more comprehensive information about the antioxidant reserve, and (iii) study the effects of RAS inhibition at the AT1 receptor site by losartan on the myocardial enzymatic and non-enzymatic antioxidants (SOD, GSHPx, catalase, vitamins A and E) and oxidative stress (Lipid hydroperoxides, reduced and oxidized glutathione and the redox ratio) in relation to the changes in hemodynamic function during the sequelae of congestive heart failure. It is concluded that inhibition of the RAS at the AT1 receptor site with losartan, in addition to reducing cardiac remodeling and improving hemodynamic function, reduces oxidative stress and improves myocardial endogenous antioxidants subsequent to myocardial infarction. The study suggests a newer role for losartan in the treatment of heart failure. Although changes in the SOD and catalase activities during heart failure correlated with changes in mRNA for these enzymes, the precise mechanism/s for decrease in oxidative, stress and improvement in antioxidant reserve after losartan treatment is/are unclear at this time. (Abstract shortened by UMI.).

Author : Emmett Allison
Publisher : States Academic Press
ISBN 13 : 9781639897711
Total Pages : 0 pages
Book Rating : 4.12/5 ( download)

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Download or read book Mechanisms and Modulation of Oxidative Stress written by Emmett Allison and published by States Academic Press. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative stress refers to a condition caused by an imbalance between the systemic expression of reactive oxygen species (ROS) and the ability of a biological system to quickly detoxify the reactive intermediates or repair the harm. Strand breaks in DNA and base damage are caused by oxidative stress. It can interrupt normal mechanisms of cellular signaling and has been linked to the development of a number of diseases such as cancer, cardiovascular diseases and neurodegenerative diseases. Modulation of oxidative stress is done specifically through the regulation of gene transcription, such as the activation or inhibition of Nrf2. It is regarded as an important strategy for developing new drugs for some of the pathologies, including neoplastic and cardiovascular diseases, that are resistant to other treatments. This book provides significant information to help develop a good understanding of oxidative stress mechanisms and modulation. It presents researches and studies performed by experts across the globe. The extensive content of this book provides the readers with a thorough understanding of this subject.

Author : Luciano Saso
Publisher : Elsevier
ISBN 13 : 0443192480
Total Pages : 308 pages
Book Rating : 4.87/5 ( download)

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Download or read book Modulation of Oxidative Stress written by Luciano Saso and published by Elsevier. This book was released on 2023-08-01 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids. This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out. Provides the latest updates in the fast-developing field of REDOX biochemistry and pharmacology Presents content that is clear and easy to read Useful for researchers and instructors in many fields

Author : Hande Gurer-Orhan
Publisher : MDPI
ISBN 13 : 9783039432288
Total Pages : 298 pages
Book Rating : 4.81/5 ( download)

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Download or read book Modulators of Oxidative Stress written by Hande Gurer-Orhan and published by MDPI. This book was released on 2020-11-03 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book starts with the editors' preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress.