Models Of Obesity

Author : Stanley J. Ulijaszek
Publisher : Cambridge University Press
ISBN 13 : 1108515150
Total Pages : 250 pages
Book Rating : 4.53/5 ( download)

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Download or read book Models of Obesity written by Stanley J. Ulijaszek and published by Cambridge University Press. This book was released on 2017-10-12 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taking a comparative approach, this book investigates the ways in which obesity and its susceptibilities are framed in science and policy and how they might work better. Providing a clear, authoritative voice on the debate, the author builds on early work to engage further in ecological and complexity thinking in obesity. Many of the models that have emerged since obesity became a population-level issue are examined, including the energy balance model, and models used to examine human body fatness from a range of perspectives including evolutionary, anthropological, environmental, and political viewpoints. The book is ideal for those working on, or interested in, obesity science, health policy, health economics, evolutionary medicine, medical sociology, nutrition and public health who want to understand the shifts that have taken place in obesity science, policy, and intervention in the past forty years.

Author : Michael F.W. Festing
Publisher : Springer
ISBN 13 : 1349042013
Total Pages : 263 pages
Book Rating : 4.12/5 ( download)

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Download or read book Animal Models of Obesity written by Michael F.W. Festing and published by Springer. This book was released on 1979-06-17 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Thomas Weichhart
Publisher : Humana Press
ISBN 13 : 9781617794292
Total Pages : 0 pages
Book Rating : 4.95/5 ( download)

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Download or read book mTOR written by Thomas Weichhart and published by Humana Press. This book was released on 2011-12-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its discovery, the mammalian target of rapamycin (mTOR) has been shown to regulate many critical molecular processes in eukaryotes such as metabolism, growth, survival, aging, synaptic plasticity, memory, and immunity. In mTOR: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study mTOR. These include methods and techniques used for the study of the mTOR pathway and potential therapeutic applications of mTOR inhibitors such as, immunosuppressive and anticancer agents. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, mTOR: Methods and Protocols seeks to aid scientists in the further study of this crucially important molecule ranging from the analysis of signal transduction events within a cell to the assessment of complex human diseases such as metabolic disorders or cancer.

Author : Bartholomew Ibeh
Publisher : BoD – Books on Demand
ISBN 13 : 1789231647
Total Pages : 410 pages
Book Rating : 4.49/5 ( download)

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Download or read book Experimental Animal Models of Human Diseases written by Bartholomew Ibeh and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309089964
Total Pages : 277 pages
Book Rating : 4.68/5 ( download)

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Download or read book Weight Management written by Institute of Medicine and published by National Academies Press. This book was released on 2003-12-01 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary purpose of fitness and body composition standards in the U.S. Armed Forces has always been to select individuals best suited to the physical demands of military service, based on the assumption that proper body weight and composition supports good health, physical fitness, and appropriate military appearance. The current epidemic of overweight and obesity in the United States affects the military services. The pool of available recruits is reduced because of failure to meet body composition standards for entry into the services and a high percentage of individuals exceeding military weight-for-height standards at the time of entry into the service leave the military before completing their term of enlistment. To aid in developing strategies for prevention and remediation of overweight in military personnel, the U.S. Army Medical Research and Materiel Command requested the Committee on Military Nutrition Research to review the scientific evidence for: factors that influence body weight, optimal components of a weight loss and weight maintenance program, and the role of gender, age, and ethnicity in weight management.

Author : Andrew J. Krentz
Publisher : Springer
ISBN 13 : 3030117480
Total Pages : 556 pages
Book Rating : 4.81/5 ( download)

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Download or read book Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease written by Andrew J. Krentz and published by Springer. This book was released on 2019-04-02 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Author : Claude Bouchard
Publisher :
ISBN 13 :
Total Pages : 352 pages
Book Rating : 4.41/5 ( download)

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Download or read book Regulation of Body Weight written by Claude Bouchard and published by . This book was released on 1996-06-19 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fact that about 30-40% of the adults in the Western world are overweight or obese testifies to the frequency of the disturbances in body weight regulation. Scientists have established that caloric intake, macronutrient composition of the diet, basal and resting metabolic rate, thermic response to food, energy expenditure associated with movement and physical activity, and preferential storage of the surplus of calories as fat or lean tissues are critical determinants of energy balance and body weight. While much has been learned, the field is poised for major advances with the advent of a variety of imaging techniques, progress in quantitative and molecular genetics, use of transgenic rodent models and of breeding experiments with informative inbred strains, availability of stable isotopes for metabolic and behavioral studies, and a growing number of useful experimental animal and human models. This volume takes an integrative approach to obesity. It is structured around four major topics: (1) the animal and human models currently available for the study of body weight regulation with their strengths and limitations, (2) the molecular and genetic basis of the regulation of body weight, (3) the metabolic and physiological mechanisms involved, and (4) the behavioral and social determinants. The 13 background papers provide a critical overview of the present knowledge base while the group reports summarize the extensive deliberations of 38 international experts. Particular emphasis has been given to promising research areas and on the advances needed to ensure a better understanding of the biological and behavioral mechanisms of the regulation of body weight, with a particular emphasis on overweight and obesity.

Author : Patrick C. Even
Publisher : Frontiers Media SA
ISBN 13 : 2889454258
Total Pages : 161 pages
Book Rating : 4.59/5 ( download)

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Download or read book Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? written by Patrick C. Even and published by Frontiers Media SA. This book was released on 2018-02-15 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases.

Author : Michael Francis Wogan Festing
Publisher :
ISBN 13 : 9780333253397
Total Pages : 258 pages
Book Rating : 4.96/5 ( download)

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Download or read book Animal Models of Obesity written by Michael Francis Wogan Festing and published by . This book was released on 1979 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Wiley
Publisher : John Wiley & Sons
ISBN 13 : 1118734297
Total Pages : 194 pages
Book Rating : 4.92/5 ( download)

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Download or read book Obesity and Overeating written by Wiley and published by John Wiley & Sons. This book was released on 2013-07-12 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the increasing worldwide incidence of obesity and the resulting increase in metabolic disorders such as diabetes, cardiovascular diseases and some cancers, an understanding of the multitude of factors that contribute to obesity is crucial for researchers to develop more effective treatments. This collection of overviews and protocols provides the reader with an introduction to the major features of obesity research, including the interplay between energy balance, hormones and neurobiological networks. An overview is provided which describes the animal models of obesity most commonly utilized in research. A standardized laboratory protocol for producing diet?]induced obesity (DIO) in both mouse and rat is provided as are protocols that describe how diet formulation can be modified to generate mouse models of human metabolic pathologies. Protocols are also provided for testing the effects of dietary manipulations, caloric restriction and potential therapeutics. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of obesity research for students or interdisciplinary collaborators.