Middle Molecular Strategy

Author : Koichi Fukase
Publisher : Springer Nature
ISBN 13 : 9811624585
Total Pages : 357 pages
Book Rating : 4.82/5 ( download)

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Download or read book Middle Molecular Strategy written by Koichi Fukase and published by Springer Nature. This book was released on 2021-07-13 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights recently discovered aspects of “middle-size molecules,” focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex natural products; (3) special synthetic methods for π-conjugated functional molecules; and (4) novel synthetic methods using flow chemistry. Given its scope, the book is of interest to industrial researchers and graduate students in the fields of organic chemistry, medicinal chemistry, and materials science.

Author : Koichi Fukase
Publisher : Springer
ISBN 13 : 9789811624575
Total Pages : 357 pages
Book Rating : 4.77/5 ( download)

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Download or read book Middle Molecular Strategy written by Koichi Fukase and published by Springer. This book was released on 2021-08-16 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights recently discovered aspects of “middle-size molecules,” focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex natural products; (3) special synthetic methods for π-conjugated functional molecules; and (4) novel synthetic methods using flow chemistry. Given its scope, the book is of interest to industrial researchers and graduate students in the fields of organic chemistry, medicinal chemistry, and materials science.

Author : Li Di
Publisher : Elsevier
ISBN 13 : 0080557619
Total Pages : 549 pages
Book Rating : 4.18/5 ( download)

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Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Author : A. Hemantaranjan
Publisher : Scientific Publishers
ISBN 13 : 9386102196
Total Pages : 474 pages
Book Rating : 4.95/5 ( download)

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Download or read book Plant Stress Tolerance Physiological & Molecular Strategies written by A. Hemantaranjan and published by Scientific Publishers. This book was released on 2016-03-01 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book entitled "Plant Stress Tolerance – Physiological & Molecular Strategies" has been especially edited for holistic development of the science of agriculture and crop production under distinctly changing environment. Resource utilization is always overlooked; hence a brief focus on sustainability has been remarkably presented to prove the meaningfulness of this publication. This book brings ingenious applied researches highlighting the major environmental factors coupled with scrupulous strategies in solving abiotic stresses in varied micro and macro agro-climatic conditions , in general, and unfolding the basis for tolerance mechanisms in plant systems, in particular.

Author : Yuichi Kobayashi
Publisher : Springer
ISBN 13 : 9811362440
Total Pages : 355 pages
Book Rating : 4.46/5 ( download)

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Download or read book Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules written by Yuichi Kobayashi and published by Springer. This book was released on 2019-05-30 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.

Author : Koichi Fukase
Publisher : Springer
ISBN 13 : 9789811624605
Total Pages : 0 pages
Book Rating : 4.07/5 ( download)

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Download or read book Middle Molecular Strategy written by Koichi Fukase and published by Springer. This book was released on 2022-07-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights recently discovered aspects of “middle-size molecules,” focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex natural products; (3) special synthetic methods for π-conjugated functional molecules; and (4) novel synthetic methods using flow chemistry. Given its scope, the book is of interest to industrial researchers and graduate students in the fields of organic chemistry, medicinal chemistry, and materials science.

Author : Eli A. Friedman
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 586 pages
Book Rating : 4.68/5 ( download)

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Download or read book Strategy in Renal Failure written by Eli A. Friedman and published by John Wiley & Sons. This book was released on 1978 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : G. Krick
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805599072
Total Pages : 202 pages
Book Rating : 4.78/5 ( download)

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Download or read book On-Line Hemodiafiltration: The Journey and the Vision written by G. Krick and published by Karger Medical and Scientific Publishers. This book was released on 2011-12-20 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: On-line HDF represents a major technical development in the delivery of hemodialysis therapy: It combines the properties of increased diffusion available in current high-flux membranes with convective removal of between 6 and 30 liters per treatment and requires the use of ultrapure water and online filtration of replacement fluid. On-line HDF has been successfully introduced in Europe and Asia and is routinely prescribed for dialysis patients in these regions.The book at hand summarizes the history and achievements of on-line HDF in four parts: A report of the technological development in both machine and fiber/dialyzer is followed by a description of the challenges encountered in the evolution of on-line HDF, collecting the accounts of clinical key opinion leaders who had been involved in its early application. The third part presents a comprehensive review of the clinical results achieved with on-line HDF from its inception to the present times, in which it represents the clinical golden standard. The fourth and final part is dedicated to on-line HDF as a ‘vision’ for the future.

Author : Syed Ibrahim Rizvi
Publisher : Springer
ISBN 13 : 9811316996
Total Pages : 386 pages
Book Rating : 4.99/5 ( download)

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Download or read book Molecular Basis and Emerging Strategies for Anti-aging Interventions written by Syed Ibrahim Rizvi and published by Springer. This book was released on 2018-11-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.

Author : Claude Jacobs
Publisher : OUP Oxford
ISBN 13 : 0192629719
Total Pages : 321 pages
Book Rating : 4.15/5 ( download)

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Download or read book Optimal Treatment Strategies in End-stage Renal Failure written by Claude Jacobs and published by OUP Oxford. This book was released on 2002 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past 4O years there have been major conceptual and technical advances in the domain of dialysis methods and renal/organ transplantation for long-term treatment of patients with End-Stage Renal Failure (ESRF). This now enables better defined, more selective strategies of treatment tobe undertaken, according to patient-specific criteria such as age or underlying renal disease also taking into account the lifetime duration of these treatments. For many patients this implies necessary successive changes of mode of therapy depending on their availability, occurrence ofmedical/technical complications or failure and social-environmental and economic factors. This rationale has inspired the structure of this volume which is divided into four sections: 1/ A descriptive overview of the various modes of renal replacement therapy (RRT): Extracorporeal dialysis/filtration, peritoneal dialysis, kidney and multi-organ transplantation.2/ Most appropriate indications and use of these methods, respective advantages, drawbacks and outcome in children,pregnant women and elderly patients 3/ In diabetic patients and in patients with hereditary/congenital diseases. 4/ The ethical issues generated by this new domain in Medicine by limitations in treatment facilities or medical dilemmas for acceptance, best technical choices, withdrawal or terminationof RRT in individual patients. Finally, contributors form Eastern European Countries, Africa and Far Eastern Countries analyse the current status of RRT in their respective geographical area and the ways and means required for a wider implementation of RRT in thus far lesser economically developed countries where the greatmajority of the populations still have no access to these life-saving therapeutic procedures.