Microsurgical Models In Rats For Transplantation Research

Author : Arnulf Thiede
Publisher : Springer Science & Business Media
ISBN 13 : 3642616577
Total Pages : 412 pages
Book Rating : 4.70/5 ( download)

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Download or read book Microsurgical Models in Rats for Transplantation Research written by Arnulf Thiede and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preclinical experimental transplantation research that is based on microsurgical models in rats fulfills two indispensable conditions for modern organ transplanta tion research: Almost all organ grafts can be performed on the rat with an amount of technical effort that is still justifiable. Thus transplantation models that are analogous to human organ transplantation can be developed, tested, and evaluated. This fulfills a necessary condition from the standpoint of surgery. With the species rat, we have a great variety of genetically different inbred strains. From the immunological point of view this is an indispensable prerequisite for the investigation of preclinical transplantation models that can be expected to produce controllable, reproducible results. In vivo experimental results can be supplemented by and correlated to in vitro tests. Lately these experimental results are being greatly expanded and more precisely defined by the application of immunohistological methods that have been established recently in Kiel. In this book we hope to present a cross section of the microsurgical models in use today and of current immunological and immunohistological models. Furthermore, we wish to record the present state of microsurgical organ transplantation research and to show its relationship to the current state and development of clinical organ transplantation. A special aspect of our Kiel research group is the long-term, well-functioning, interdisciplinary cooperation between surgery, immunology, and pathology. Through this cooperation we attempt to provide an atmosphere in which theoretical and practical viewpoints can mutually influence each other.

Author : Wolfgang Timmermann
Publisher : Springer Science & Business Media
ISBN 13 : 3642721400
Total Pages : 655 pages
Book Rating : 4.03/5 ( download)

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Download or read book Organtransplantation in Rats and Mice written by Wolfgang Timmermann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Main focus of the new book will be the description and discussion of rat and mouse models for organ transplantation. Various microsurgical techniques will be presented which allow transplantation of functional organs in syngeneic systems. In particular, the extremely difficult methods necessary for organ transplantation in mice will be presented and evaluated. Besides these practical aspects the book will also cover the theoretical sides of organ transplantation like the immunobiology of allotransplantation. Special emphasis will be given to the resurgent field of xenotransplantation. The results from xenograft models developed in the recent years using rats or mice will be reviewed and their impact on future human xenotransplantation will be discussed.

Author : Peter Girman
Publisher : Springer
ISBN 13 : 3319145592
Total Pages : 252 pages
Book Rating : 4.94/5 ( download)

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Download or read book Rat Experimental Transplantation Surgery written by Peter Girman and published by Springer. This book was released on 2015-11-16 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the book is to describe tested microsurgical procedures of kidney, pancreas, islets, heat, liver and small bowel transplantation. All procedures written in the book are used in our experimental research laboratory and their description will be provided by an experienced researcher. The book is organized into ‘General’ and ‘Specific’ sections. The ‘General’ section will include principles, doses and available drugs for rat anaesthesia, the surgical anatomy of the rat, a brief review of immunosuppressant’s used in rat models, a description of basic surgical techniques and blood sampling. The ‘Specific’ section will include a description of the rat model with the appropriate organ failure relevant to the organ transplantation, which will be followed by a detailed description of the surgical procedure with high quality pictures of key steps. Each chapter will describe ‘tips and tricks’ including practical advice and recommendations.

Author : Peter Girman
Publisher :
ISBN 13 : 9783319145600
Total Pages : pages
Book Rating : 4.06/5 ( download)

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Download or read book Rat Experimental Transplantation Surgery written by Peter Girman and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the book is to describe tested microsurgical procedures of kidney, pancreas, islets, heat, liver and small bowel transplantation. All procedures written in the book are used in our experimental research laboratory and their description will be provided by an experienced researcher. The book is organized into 'General' and 'Specific' sections. The 'General' section will include principles, doses and available drugs for rat anaesthesia, the surgical anatomy of the rat, a brief review of immunosuppressant's used in rat models, a description of basic surgical techniques and blood sampling. The 'Specific' section will include a description of the rat model with the appropriate organ failure relevant to the organ transplantation, which will be followed by a detailed description of the surgical procedure with high quality pictures of key steps. Each chapter will describe 'tips and tricks' including practical advice and recommendations.

Author : Donald V. Cramer
Publisher : CRC Press
ISBN 13 : 9780849336294
Total Pages : 372 pages
Book Rating : 4.95/5 ( download)

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Download or read book Handbook of Animal Models in Transplantation Research written by Donald V. Cramer and published by CRC Press. This book was released on 1993-12-09 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Animal Models in Transplantation Research is a new surgical handbook that provides detailed information concerning the transplantation of a variety of tissues in experimental animals. The text provides a practical guide for experienced investigators to develop new surgical transplantation models for application in a laboratory setting. Each chapter gives consistent descriptions of the anatomical considerations, the surgical model, and potential applications of the procedure. The organ systems covered include the heart and/or lung, liver, small bowel, kidneys, and bone marrow. The species selected for representation of each experimental model is based upon the usefulness and frequency of the model for studies in transplantation research. This book is important for all experimental surgeons, transplantation biologists, and students of surgical research.

Author : Eberhard Deltz
Publisher : Springer Science & Business Media
ISBN 13 : 3642710875
Total Pages : 302 pages
Book Rating : 4.72/5 ( download)

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Download or read book Small-Bowel Transplantation written by Eberhard Deltz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: In contrast to the continuously increasing success in kidney, liver, heart, and pancreas transplantation, small-bowel transplantation has not shown simi larly impressive progress until recently. The few clinical attempts at small-intestinal transplantation in the late 1960s and early 1970s were unsuccessful. In spite of these initial failures, a few groups of surgeons continued to investigate the problems of small-bowel transplantation from the technical, functional, and immunologic point of view. Now, about 15 years later, conditions have changed. Total parenteral nutrition has made tremendous progress, thus maintaining patients with short-bowel syndrome who are potential recipients of small-bowel grafts in an acceptable physical condition. Immunologists and clinicians have furt hermore been able to expand our knowledge of basic immunologic reactions induced by transplanted organs. In addition, within the last 8 years, new immunosuppressive drugs and regimens have been introduced which have proved to be extremely effective. Taking all these aspects into account, we regarded it as an extremely worthwhile and effective undertaking to invite scientists from all over the world who are working in the field of small-bowel transplantation to participate in a symposium on this topic. This meeting, the first to deal exclusively with small-bowel transplantation, was held in Kiel, West Ger many, in October 1985. Its aims were twofold: 1. ) To'stimulate direct communication between basic scientists and clini cians 2.

Author : Jann Hau
Publisher : CRC Press
ISBN 13 : 142004091X
Total Pages : 569 pages
Book Rating : 4.13/5 ( download)

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Download or read book Handbook of Laboratory Animal Science written by Jann Hau and published by CRC Press. This book was released on 2002-10-28 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of an international bestseller, this book provides veterinary specialists as well as veterinary and biomedical researchers with detailed information about laboratory animal genetics, diseases, health monitoring, nutrition, and environmental impact on animal experiments. Completely revised and updated, Volume I now contains expand

Author : Maria-Angeles Aller
Publisher : Bentham Science Publishers
ISBN 13 : 1608050688
Total Pages : 226 pages
Book Rating : 4.80/5 ( download)

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Download or read book Microsurgery in Liver Research written by Maria-Angeles Aller and published by Bentham Science Publishers. This book was released on 2009-10-28 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last two decades microsurgery has progressively taken the place of macrosurgery since it largely improves the experimental models in liver research. This is a concise but comprehensive book focusing on key issues in microsurgical techniques for

Author : B. R. Christie
Publisher : CRC Press
ISBN 13 : 9783718655236
Total Pages : 516 pages
Book Rating : 4.33/5 ( download)

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Download or read book Experimental Transplantation Models in Small Animals written by B. R. Christie and published by CRC Press. This book was released on 1995-03-01 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to small animal use in transplantation research, for biomedical researchers. In most cases, the techniques were developed by the chapter authors. While some chapters are of general interest, other deal with specific procedures, mostly in rats and mice but with some rabbit work included. In acknowledgment of the ethical aspects of live animal experimentation, the detailed handling of the animals and the description of anesthesia and analgesia are central to many of the chapters. Thoroughly illustrated in bandw. Annotation copyright by Book News, Inc., Portland, OR

Author : H Gregerson
Publisher : CRC Press
ISBN 13 : 9783718654963
Total Pages : 802 pages
Book Rating : 4.62/5 ( download)

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Download or read book Essentials of Experimental Surgery written by H Gregerson and published by CRC Press. This book was released on 1996-05-28 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all aspects of experimental gastrointestinal research including anatomy, physiology, surgical procedures and animal experimental models As well as being a useful reference guide to established scientists, it serves as an ideal introduction to the field of gastroenterology By consulting the book, the appropriate animal species and experimental model can be chosen for physiological and pathophysiological studies