Metronomic Chemotherapy

Author : Guido Bocci
Publisher : Springer
ISBN 13 : 3662436043
Total Pages : 302 pages
Book Rating : 4.42/5 ( download)

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Download or read book Metronomic Chemotherapy written by Guido Bocci and published by Springer. This book was released on 2014-09-04 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Author : Guido Bocci
Publisher : Springer
ISBN 13 : 9783662513194
Total Pages : 0 pages
Book Rating : 4.96/5 ( download)

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Download or read book Metronomic Chemotherapy written by Guido Bocci and published by Springer. This book was released on 2016-09-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Author : Manzoor Ahmad Mir
Publisher : CRC Press
ISBN 13 : 1040013716
Total Pages : 255 pages
Book Rating : 4.17/5 ( download)

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Download or read book Novel Approaches in Metronomic Chemotherapy for Breast Cancer Treatment written by Manzoor Ahmad Mir and published by CRC Press. This book was released on 2024-05-28 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the latest research and developments in the field of metronomic chemotherapy for breast cancer. It presents the principles and mechanisms of metronomic chemotherapy, preclinical and clinical studies, and the latest developments in drug delivery systems and nanoformulations. The clinical pharmacology of metronomic chemotherapy, including pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions, are also examined. Key Features: Introduces metronomics therapy in the neoadjuvant and adjuvant treatment of breast cancer Explores the potential of metronomics in terms of personalized chemotherapy Present pharmacological bases of metronomic chemotherapy Covers the latest developments in drug delivery systems, nanotechnology, and nanoformulations Discusses antiangiogenic effects and the impact of metronomics on immunity This book is useful for students, researchers, oncologists, pharmacologists, and healthcare experts interested in understanding the clinical potential of metronomic chemotherapy in breast cancer.

Author :
Publisher : Academic Press
ISBN 13 : 0323905560
Total Pages : 296 pages
Book Rating : 4.65/5 ( download)

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Download or read book Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy written by and published by Academic Press. This book was released on 2022-01-14 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field. Provides the most updated reviews on anti-angiogenic drugs as chemosensitizers by leaders in the field Encompasses summarized tables and schematic diagrams in each chapter to give a clear overview on recent findings in a didactic manner Brings not only relevant information of current research but also new ideas and suggestions for further investigations to help advance the field

Author : Guido Bocci
Publisher : Mdpi AG
ISBN 13 : 9783036592800
Total Pages : 0 pages
Book Rating : 4.06/5 ( download)

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Download or read book Clinical Applications of Metronomic Chemotherapy written by Guido Bocci and published by Mdpi AG. This book was released on 2023-12-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metronomic chemotherapy is now, finally, in clinical use. After 20 years of preclinical development and clinical trials, the emerging data will be of paramount importance in allowing us to assess the impact of metronomic chemotherapy on different tumor types. Indeed, it is likely that the next decade will see a major reassessment of the possible applications of metronomic chemotherapy, both alone and in combination with new therapeutic approaches such as immunotherapies, for the management of cancer. Moreover, the results of clinical trials will likely profoundly affect the direction of the laboratory efforts that are going on in parallel and aiming to improve the personalization of this therapeutic strategy. This Special Issue is our attempt to cover the past and present clinical results that have brought us to this pivotal moment and will form the basis of future clinical developments. Scientists and clinicians caring for cancer patients are well aware of the challenges in dealing with this particular therapeutic approach; one such challenge is obtaining improvements in patient survival without significant toxicity. This edition includes clinical research on chemotherapy and ongoing controversies related to metronomic chemotherapy.

Author : B. Kyewski
Publisher : Springer Science & Business Media
ISBN 13 : 3540277021
Total Pages : 331 pages
Book Rating : 4.26/5 ( download)

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Download or read book CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential written by B. Kyewski and published by Springer Science & Business Media. This book was released on 2006-01-09 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.

Author : Albert Altchek
Publisher : Elsevier
ISBN 13 : 008049451X
Total Pages : 568 pages
Book Rating : 4.17/5 ( download)

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Download or read book Diagnosis and Management of Ovarian Disorders written by Albert Altchek and published by Elsevier. This book was released on 2003-09-04 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. KEY FEATURES * Includes updated information on early diagnosis of ovarian cancer * Reviews new diagnostic techniques for ovarian disorders * Discusses latest information on reproductive technology * Presents translational treatment linking laboratory research with clinical medicine

Author : Nick Chen
Publisher : Rowman & Littlefield
ISBN 13 : 1538101610
Total Pages : 210 pages
Book Rating : 4.12/5 ( download)

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Download or read book Rx for Hope written by Nick Chen and published by Rowman & Littlefield. This book was released on 2018-10-16 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: In our current era of rapidly developing cancer drugs and therapies, we also see improvement of cancer treatment outcomes stagnating when it comes to determining quality of life or long-term survival. This is because while new treatments are making small incremental progress in outcomes, most cancer patients still depend on conventional methods that are both toxic and ineffective. While new cancer drugs are becoming more precise or targeted, less attention is being paid to the overall health and wellbeing of the patient, which we propose is essential for long-term cancer control and improving a patient’s quality of life. Rx for Hope, backed by rigorous science and real-life patient cases, calls for an urgent reevaluation of the current conventional approach to cancer treatments and encourages a progressive treatment model combining metronomic low-dose chemotherapy with complementary integrative medicine. Along with new, breakthrough immunotherapy drugs, these treatments can potentially create a response powerful enough to not only eradicate the presence of cancer but also to prevent it from returning. Because every 23 seconds someone in America is diagnosed with cancer, the number of people affected is growing rapidly. The American Cancer Society estimates that nearly two million new patients will need treatment in the coming year. Judging by current trends and methods of treatment, far too many of these people will be treated without the benefits of low-dose chemotherapy, and even less will enjoy the positive impact of immune-supportive complementary integrative medicine. Rx for Hope offers insight into a powerful way of treating cancer that patients and doctors can implement immediately for optimal results.

Author : Kenneth K.W. To
Publisher : Academic Press
ISBN 13 : 0128199032
Total Pages : 460 pages
Book Rating : 4.39/5 ( download)

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Download or read book Drug Repurposing in Cancer Therapy written by Kenneth K.W. To and published by Academic Press. This book was released on 2020-07-29 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Author : Rüdiger Liersch
Publisher : Springer Science & Business Media
ISBN 13 : 3540782818
Total Pages : 238 pages
Book Rating : 4.10/5 ( download)

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Download or read book Angiogenesis Inhibition written by Rüdiger Liersch and published by Springer Science & Business Media. This book was released on 2009-12-24 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in this exciting field.