Author : Lluis Fajas
Publisher : Frontiers Media SA
ISBN 13 : 2889454843
Total Pages : 70 pages
Book Rating : 4.46/5 ( download)
Book Synopsis Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions by : Lluis Fajas
Download or read book Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions written by Lluis Fajas and published by Frontiers Media SA. This book was released on 2018-04-27 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer. However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor’s origin, the specific genetic alterations and the surrounding microenvironment. In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer.