Mechanisms Of Intestinal Inflammation

Author : R. Duchmann
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387879
Total Pages : 246 pages
Book Rating : 4.72/5 ( download)

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Download or read book Mechanisms of Intestinal Inflammation written by R. Duchmann and published by Springer Science & Business Media. This book was released on 2004-04-30 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years considerable progress has been achieved in regard to our understanding of the induction and modulation of the immune response in the intestinal mucosa. It is clear that this mucosal immune reaction is predominantly steered by certain T-cell populations, which are characterized by their cytokine secretion profile. Less well known are the conditions under which the uptake and processing of a specific antigen leads to a certain immune response, whether it be protective, tolerant or inflammatory. However, here again distinct progress has been made in our understanding. Equally significant for immune regulation in the gut appears to be so-called innate immunity. Every shift of equilibrium in the highly regulated mucosal immune reaction is accompanied by an inflammatory reaction and destruction of the mucosa. In nearly all cases, this inflammatory response is dependent on the presence of bacterial intestinal flora. This book, the proceedings of Falk Symposium 133 on Mechanisms of Intestinal Inflammation: Implications for Therapeutic Intervention in IBD', held in Berlin, Germany, on 10-11 June 2003, summarizes present knowledge in the area of unspecific and specific immune reactions in the gut, recording the gaps in our knowledge and, in particular, presenting the possibilities of targeted intervention. The link to inflammatory bowel diseases - Crohn's disease and ulcerative colitis - is always in focus. Chapters by an international panel of basic scientists, clinical researchers and clinicians also record the problems which can originate through today's possible modulation of the immune reaction, setting the basis for review of clinical problems. This book is valuable readings for all scientists and physicians, who, from different perspectives, have an interest in research on IBD and in the clinical management of these diseases.

Author : Richard Blumberg
Publisher : Springer Science & Business Media
ISBN 13 : 0387337784
Total Pages : 262 pages
Book Rating : 4.84/5 ( download)

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Download or read book Immune Mechanisms in Inflammatory Bowel Disease written by Richard Blumberg and published by Springer Science & Business Media. This book was released on 2007-02-26 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.

Author : Lorraine J. Maher
Publisher :
ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.72/5 ( download)

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Download or read book Mechanisms of Intestinal Inflammation written by Lorraine J. Maher and published by . This book was released on 2000 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Soichiro Miura
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041443
Total Pages : 125 pages
Book Rating : 4.42/5 ( download)

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Download or read book Intestinal Immune System written by Soichiro Miura and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: These negative regulatory mechanisms of the intestinal immune system are disturbed in certain disease conditions, causing the immunocompetent cells to respond to food components and commensal bacteria by becoming activated and to overproduce inflammatory cytokines and chemokines. These disease conditions include food allergies, such as celiac disease, and the inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, although their exact etiological mechanisms remain to be revealed. --Book Jacket.

Author : A. Stallmach
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387473
Total Pages : 350 pages
Book Rating : 4.73/5 ( download)

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Download or read book Induction and Modulation of Gastrointestinal Inflammation written by A. Stallmach and published by Springer Science & Business Media. This book was released on 1998-12-31 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, the proceedings of Falk Symposium No. 104, organized in collaboration with the Society of Mucosal Immunology, and held in Saarbrucken, Germany, March 5-7 1998, is centered around the immunological mechanisms of mucosal protection and their disturbances leading to intestinal inflammation and destruction. This is a rapidly expanding field involving recent knowledge of basic immunology and cell biology as well as clinical observations. The conference and this book summarize very recent data in this field and suggest strategies for future research and clinical applications, and will be of interest to both basic scientists and clinicians.

Author : Sami Karoui
Publisher : BoD – Books on Demand
ISBN 13 : 953307891X
Total Pages : 348 pages
Book Rating : 4.15/5 ( download)

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Download or read book Inflammatory Bowel Disease written by Sami Karoui and published by BoD – Books on Demand. This book was released on 2012-01-27 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is dedicated to inflammatory bowel disease, and the authors discuss the advances in the pathogenesis of inflammatory bowel disease, as well as several new parameters involved in the etiopathogeny of Crohn's disease and ulcerative colitis, such as intestinal barrier dysfunction and the roles of TH 17 cells and IL 17 in the immune response in inflammatory bowel disease. The book also focuses on several relevant clinical points, such as pregnancy during inflammatory bowel disease and the health-related quality of life as an end point of the different treatments of the diseases. Finally, advances in management of patients with inflammatory bowel disease are discussed, especially in a complete review of the recent literature.

Author : Stephan R. Targan
Publisher : John Wiley & Sons
ISBN 13 : 1444359118
Total Pages : 1429 pages
Book Rating : 4.14/5 ( download)

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Download or read book Inflammatory Bowel Disease written by Stephan R. Targan and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 1429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the state-of–the-art book on inflammatory bowel disease you have been waiting for Written and edited by international experts in gastroenterology this up-to-date volume provides a complete review of the basic science behind inflammatory bowel disease (IBD), as well as evidence-based clinical guidance on diagnosis, treatment and long-term management of IBD. In 50 chapters the authors cover the latest and most promising treatment modalities and the science behind them. There are chapters which cover the advances in the medical and surgical treatment of conditions such as Crohn's disease and ulcerative colitis, as well as chapters focusing on nutrition, imaging and complementary medicine. This is an invaluable information resource for all those in the medical team treating patients with IBD. Whether you are a gastroenterologist, gastrointestinal surgeon or GI nurse specialist this book deserves a place in your library.

Author : Lina Yakymenko Alkaissi
Publisher : Linköping University Electronic Press
ISBN 13 : 9176852784
Total Pages : 65 pages
Book Rating : 4.81/5 ( download)

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Download or read book Bacterial epithelial interaction in intestinal inflammation written by Lina Yakymenko Alkaissi and published by Linköping University Electronic Press. This book was released on 2018-04-27 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intestine is constantly exposed to bacteria, invading viruses and ingested food. The intestinal barrier serves as a gate preventing passage of harmful components, and at the same time maintaining absorption of nutrients and water. There are over 300 different bacteria species in the human gastrointestinal tract (GI) comprising over 10 times as many cells as the human body. These bacteria are both of commensal and pathogenic strains in which commensal bacteria and antimicrobial peptides have an important role of controlling the intestinal colonization. The intestinal flora is sampled by the membranous cells (M cells) that are present in the follicle associated epithelium (FAE). Antigens encounter immune cells found in Peyer’s patches located in the distal ileum with FAE overlaying them. Due to environmental factors, genetic predisposition, immune dysregulation or dysbiosis the balance can be shifted which, in turn, will lead to the defect in the barrier function, leading to the development of disorders such as Crohn’s disease (CD). CD is a chronic inflammation in the GI tract, often originating in the distal ileum in FAE and associated with an increased number of adherent invasive strains of bacteria. Specifically adherent invasive E.coli (AIEC) that have been isolated from the ileum and colon of CD patients. The aim of the present thesis was to study bacterial epithelial interaction during inflammation in in vivo, ex vivo and in vitro models. In the first project we found that that Faecalibacterium prausnitzii (FP), possess anti-inflammatory properties in the ileum of an in vivo DSS induced colitis mouse model. In the second project, we discovered that infliximab, known to have anti-inflammatory effects by binding soluble TNF and blocking TNF receptors, reduces bacterial transcytosis across colonic biopsies of CD patients and decreases transcytosis and internalization in cell monolayers in vitro. Moreover, we demonstrated that HM427 bacteria, isolated from colonic mucosa of CD patients, uses lipid raft formations to penetrate the barrier under the influence of TNF in an in vitro model. In project three, we demonstrated that LF82 bacteria, which is an adherent invasive strain of E.coli that has been isolated from the ileum of CD patients, exploits FAE of CD patients and non-IBD control patients to penetrate the barrier via the CEACAM6 receptor and long polar fimbriae. We further demonstrated that there is an increased expression of CEACM6 receptor in the FAE of CD patients, which leads to increased transcytosis of LF82 compared to non-IBD control group. In project four, our results suggested that human ?-defensin 5 significantly decreases the passage of LF82 bacteria in an in vitro and ex vivo models. Moreover, we demonstrated that CD patients have a lower expression of human ?-defensin 5 in the crypts compared to the non-IBD control patients. Taken together, our findings have given a novel insight into the etiology of CD and into the mechanisms involved in bacterial-epithelial interaction in CD.

Author : Aya Melody Westbrook
Publisher :
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.46/5 ( download)

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Download or read book Mechanisms of Intestinal Inflammation-associated Systemic Genotoxicity written by Aya Melody Westbrook and published by . This book was released on 2011 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Samuel Huber
Publisher : BoD – Books on Demand
ISBN 13 : 9535127543
Total Pages : 266 pages
Book Rating : 4.43/5 ( download)

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Download or read book New Insights into Inflammatory Bowel Disease written by Samuel Huber and published by BoD – Books on Demand. This book was released on 2016-10-26 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: The incidence of chronic inflammatory and autoimmune diseases is steadily increasing. Inflammatory bowel disease (IBD) is one example of a chronic inflammatory disease, which primarily affects the intestine but may also affect extraintestinal organs. The exact pathogenesis of IBD is currently unknown. However, it is clear that the pathogenesis is complex, involving barrier defects, changes in the intestinal microbiome, and chronic immune activation. This book aims to summarize basic aspects of these complex interactions between barrier function, microbiome, and the immune system. Of note, there is currently no cure for IBD. However, several therapies have evolved in the last years, which are overall able to-at least temporarily-suppress IBD. These therapies and the underlying mechanism are discussed.