Measurement And Analysis Of Kinetic Isotope Effects

Author :
Publisher : Academic Press
ISBN 13 : 0128122749
Total Pages : 628 pages
Book Rating : 4.47/5 ( download)

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Download or read book Measurement and Analysis of Kinetic Isotope Effects written by and published by Academic Press. This book was released on 2017-09-12 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Analysis of Enzyme Mechanism Using Isotope Effects, Volume 596, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this comprehensive update include Measurement of enzyme binding isotope effects, Chemical ligation and isotope labeling to locate dynamic effects, Measurement of heavy enzyme isotope effects, Extracting kinetic isotope effects from a global analysis of reaction progress curves, KIE of metabolic flux and enzymes, Solvent and Primary KIE on Flavin Enzymes, and The Rapid Determination of Primary Deuterium Isotope Effects on Enzyme-Catalyzed Proton Transfer at Carbon in 50/50 HOH/DOD. Readers who are interested in applying or understanding this research will find useful methods currently used for measuring isotope effects on solution and enzyme reactions. Written by pioneers of modern isotope effect research Is the only collection of modern kinetic isotope effect methods currently available

Author : Amnon Kohen
Publisher : CRC Press
ISBN 13 : 1420028022
Total Pages : 1092 pages
Book Rating : 4.27/5 ( download)

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Download or read book Isotope Effects In Chemistry and Biology written by Amnon Kohen and published by CRC Press. This book was released on 2005-11-01 with total page 1092 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of isotope effects has expanded exponentially in the last decade, and researchers are finding isotopes increasingly useful in their studies. Bringing literature on the subject up to date, Isotope Effects in Chemistry and Biology covers current principles, methods, and a broad range of applications of isotope effects in the physical, biolo

Author : Lars C. S. Melander
Publisher :
ISBN 13 :
Total Pages : 200 pages
Book Rating : 4.79/5 ( download)

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Download or read book Isotope Effects on Reaction Rates written by Lars C. S. Melander and published by . This book was released on 1960 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : E. Buncel
Publisher :
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.40/5 ( download)

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Download or read book Heavy Atom Isotope Effects written by E. Buncel and published by . This book was released on 1992 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : William Wallace Cleland
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.09/5 ( download)

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Download or read book Isotope Effects on Enzyme-catalyzed Reactions written by William Wallace Cleland and published by . This book was released on 1977 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Valentin P. Ananikov
Publisher : John Wiley & Sons
ISBN 13 : 3527678220
Total Pages : 483 pages
Book Rating : 4.28/5 ( download)

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Download or read book Understanding Organometallic Reaction Mechanisms and Catalysis written by Valentin P. Ananikov and published by John Wiley & Sons. This book was released on 2014-08-29 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring and highlighting the new horizons in the studies of reaction mechanisms that open joint application of experimental studies and theoretical calculations is the goal of this book. The latest insights and developments in the mechanistic studies of organometallic reactions and catalytic processes are presented and reviewed. The book adopts a unique approach, exemplifying how to use experiments, spectroscopy measurements, and computational methods to reveal reaction pathways and molecular structures of catalysts, rather than concentrating solely on one discipline. The result is a deeper understanding of the underlying reaction mechanism and correlation between molecular structure and reactivity. The contributions represent a wealth of first-hand information from renowned experts working in these disciplines, covering such topics as activation of small molecules, C-C and C-Heteroatom bonds formation, cross-coupling reactions, carbon dioxide converison, homogeneous and heterogeneous transition metal catalysis and metal-graphene systems. With the knowledge gained, the reader will be able to improve existing reaction protocols and rationally design more efficient catalysts or selective reactions. An indispensable source of information for synthetic, analytical, and theoretical chemists in academia and industry.

Author : Max Wolfsberg
Publisher : Springer Science & Business Media
ISBN 13 : 9048122651
Total Pages : 477 pages
Book Rating : 4.53/5 ( download)

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Download or read book Isotope Effects written by Max Wolfsberg and published by Springer Science & Business Media. This book was released on 2009-12-15 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the title suggests, Isotope Effects in the Chemical, Geological and Bio Sciences deals with differences in the properties of isotopically substituted molecules, such as differences in the chemical and physical properties of water and the heavy waters. Since the various fields in which isotope effects are applied do not only share fundamental principles but also experimental techniques, this book includes a discussion of experimental apparatus and experimental techniques. Isotope Effects in the Chemical, Geological and Bio Sciences is an educational monograph addressed to graduate students and others undertaking isotope effect research. The fundamental principles needed to understand isotope effects are presented in appropriate detail. While it is true that these principles are more familiar to students of physical chemistry and some background in physical chemistry is recommended, the text provides enough detail to make the book an asset to students in organic and biochemistry, and geochemistry.

Author : Steven Rosenberg
Publisher :
ISBN 13 :
Total Pages : 692 pages
Book Rating : 4.68/5 ( download)

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Download or read book The Elucidation of Mechanism and Transition State Structure for Enzyme and Non-enzyme Catalyzed Reactions with the Aid of Novel Methods for the Measurement of Oxygen-18 Isotope Effects written by Steven Rosenberg and published by . This book was released on 1978 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Attila Vértes
Publisher : Springer Science & Business Media
ISBN 13 : 144190719X
Total Pages : 3693 pages
Book Rating : 4.96/5 ( download)

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Download or read book Handbook of Nuclear Chemistry written by Attila Vértes and published by Springer Science & Business Media. This book was released on 2010-12-10 with total page 3693 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised and extended 6 volume handbook set is the most comprehensive and voluminous reference work of its kind in the field of nuclear chemistry. The Handbook set covers all of the chemical aspects of nuclear science starting from the physical basics and including such diverse areas as the chemistry of transactinides and exotic atoms as well as radioactive waste management and radiopharmaceutical chemistry relevant to nuclear medicine. The nuclear methods of the investigation of chemical structure also receive ample space and attention. The international team of authors consists of scores of world-renowned experts - nuclear chemists, radiopharmaceutical chemists and physicists - from Europe, USA, and Asia. The Handbook set is an invaluable reference for nuclear scientists, biologists, chemists, physicists, physicians practicing nuclear medicine, graduate students and teachers - virtually all who are involved in the chemical and radiopharmaceutical aspects of nuclear science. The Handbook set also provides further reading via the rich selection of references.

Author : Jennifer Sue Hirschi
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.82/5 ( download)

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Download or read book Application of Kinetic Isotope Effects and Theoretical Calculations to the Study of Interesting Reaction Mechanisms written by Jennifer Sue Hirschi and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A variety of biological and organic reaction mechanisms are studied using powerful tools from experimental and theoretical chemistry. These tools include the precise measurement of kinetic isotope effects (KIEs) and the use of theoretical calculations to predict KIEs as well as determine factors that contribute to reaction acceleration and selectivity. Theoretical analysis of the Swain-Schaad relationship involves the prediction of a large number of isotope effects and establishes the semiclassical boundaries of the relationship. Studies on the mechanism of oxidosqualene cyclase involve the determination of a large number of precise KIEs simultaneously. Transition state models for the Sharpless asymmetric epoxidation have been developed that explain the versatility, high selectivities, and ligand accelerated catalysis of the reaction. Theoretical predictions on the proposed enzymatic mechanism of flavin dependent amine oxidation suggest a hydride transfer mechanism and rules out mechanisms involving covalent intermediates. Finally, a theoretical analysis of Diels-Alder reactions successfully describes the unexpected exo selectivity in some of these reactions.