Mathilda Savitch

Author : Victor Lodato
Publisher : Anchor Canada
ISBN 13 : 038566981X
Total Pages : 322 pages
Book Rating : 4.18/5 ( download)

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Download or read book Mathilda Savitch written by Victor Lodato and published by Anchor Canada. This book was released on 2010-08-03 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fiercely funny and touching debut novel of a young girl uncovering the truth about her sister’s death. Fear doesn’t come naturally to Mathilda Savitch. She prefers to look directly at things nobody else can even mention: for example, her beloved older sister’s death. She was pushed in front of a train by a man who is still on the loose, and after a year of searching for clues, Mathilda has come no closer to the truth about Helene’s murder…until she cracks her email password and a whole secret life emerges — one that swiftly draws Mathilda into her sister’s world of clouded motives and strange emotions. If she can find the keys to Helene’s past, she’s sure she can wake her family from their nightmare of grief. But in crossing into that underworld and tracing her sister’s footsteps, she has to risk everything that matters to her. Mathilda Savitch is a poignant, furiously funny, and tender page-turner from an extraordinary debut novelist.

Author : Frances M. Ashcroft
Publisher : Academic Press
ISBN 13 : 0080535216
Total Pages : 505 pages
Book Rating : 4.10/5 ( download)

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Download or read book Ion Channels and Disease written by Frances M. Ashcroft and published by Academic Press. This book was released on 1999-10-20 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

Author : Victor Lodato
Publisher : Macmillan
ISBN 13 : 1250096987
Total Pages : 544 pages
Book Rating : 4.82/5 ( download)

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Download or read book Edgar and Lucy written by Victor Lodato and published by Macmillan. This book was released on 2017-03-07 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eight-year-old Edgar Fini's loyalty is torn between the two women in his life. There's his mother, Lucy, who, though she has moments where she loves him, mostly disappears at night with her various 'suitors'. And then there's his grandmother, Florence, who dotes on him to the point where she is at a loss when he isn't around. Since his father's suicide, Florence and Edgar's relationship has become obsessive, each fully dependent on the other. When Florence suddenly dies, Lucy is thrown into the role of main caretaker and doesn't know how to handle her new job. But as Edgar and Lucy adjust, they must also deal with Ron, a local butcher who wants to court Lucy, and Conrad, an unsettlingly attentive adult whose intentions are at one more sinister and more innocent than Edgar could ever know.

Author : Kirsten Reed
Publisher : Text Publishing
ISBN 13 : 1921520744
Total Pages : 218 pages
Book Rating : 4.47/5 ( download)

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Download or read book The Ice Age written by Kirsten Reed and published by Text Publishing. This book was released on 2009-06-29 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: We stopped at a roadside diner. People asked if I was his daughter. They ask all the time. Hoping, accusing. We never say yes, and we never say no. We ate our food at a booth in a hungry, self-conscious rush, straight out of the wrappers. They didn't have plates. We left a tip, just change. The waitress scooped it up straight away as we slid out of the booth. She was middle-aged and bulgy, in a proper matronly waitress's dress. She shot us what I suppose was intended to be a look of gratitude. She really only managed a weak glare. I guess that's the countryside for you. People are a little edgy.' Across the heartless expanse of middle America, a teenaged girl is riding shotgun with an older man. She watches him; she sees her fascination tallied in the black looks of waitresses, the knowing smiles of motel clerks. The man can see no proper way of conducting this relationship but is bound to her by concern and tenderness; perhaps desire. The girl craves only closeness. She knows the Ice Age is coming, and we will need to huddle together for warmth. Kirsten Reed's debut novel, with its echoes of Nabokov, Kerouac and Bret Easton Ellis, captures the translucent moment at the end of childhood in all its awkwardness, sincerity and heedless vulnerability. In prose both lyrical and earthy, comic and darkly harrowing, this extraordinary young writer creates a journey of irresistible momentum and tragic possibility. It will leave you with the sense that you have met someone significant; and you will not soon forget her.

Author : Wally Lamb
Publisher : Simon and Schuster
ISBN 13 : 1471105342
Total Pages : 480 pages
Book Rating : 4.40/5 ( download)

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Download or read book She's Come Undone written by Wally Lamb and published by Simon and Schuster. This book was released on 2012-12-11 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meet Dolores Price. She's thirteen, wise-mouthed but wounded. Beached like a whale in front of her bedroom TV, she spends the next few years nourishing herself with the chocolate, crisps and Pepsi her anxious mother supplies. When she finally rolls into young womanhood at 257 pounds, Dolores is no stronger and life is no kinder. But this time she's determined to rise to the occasion and give herself one more chance before really going belly up. In his extraordinary coming-of-age odyssey, Wally Lamb invites us to hitch an incredible ride on a journey of love, pain, and renewal with the most heartbreakingly comical heroine to come along in years. At once a fragile girl and a hard-edged cynic, so tough to love yet so inimitably loveable, Dolores is as poignantly real as our own imperfections.

Author : Sandra Cisneros
Publisher : Vintage
ISBN 13 : 0307960862
Total Pages : 152 pages
Book Rating : 4.63/5 ( download)

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Download or read book Have You Seen Marie? written by Sandra Cisneros and published by Vintage. This book was released on 2012-10-02 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The internationally acclaimed author of The House on Mango Street and winner of the PEN/Nabokov Award for Achievement in International Literature gives us a deeply moving tale of loss, grief, and healing: a lyrically told, richly illustrated fable for grown-ups about a woman’s search for a cat who goes missing in the wake of her mother’s death. The word “orphan” might not seem to apply to a fifty-three-year-old woman. Yet this is exactly how Sandra feels as she finds herself motherless, alone like “a glove left behind at the bus station.” What just might save her is her search for someone else gone missing: Marie, the black-and-white cat of her friend, Roz, who ran off the day they arrived from Tacoma. As Sandra and Roz scour the streets of San Antonio, posting flyers and asking everywhere, “Have you seen Marie?” the pursuit of this one small creature takes on unexpected urgency and meaning. With full-color illustrations that bring this transformative quest to vivid life, Have You Seen Marie? showcases a beloved author’s storytelling magic, in a tale that reminds us how love, even when it goes astray, does not stay lost forever.

Author : Jayne Anne Phillips
Publisher : Vintage
ISBN 13 : 0307271277
Total Pages : 306 pages
Book Rating : 4.73/5 ( download)

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Download or read book Lark and Termite written by Jayne Anne Phillips and published by Vintage. This book was released on 2009-01-06 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: NATIONAL BESTSELLER • From the award-winning author a "powerful and emotionally piercing" novel (The New York Times) set during the 1950 in West Virginia and Korea, that intertwines family secrets, war, dreams, and ghosts in a story about the love that unites us all. Lark and Termite is a rich, wonderfully alive novel about seventeen year old Lark and her brother, Termite, living in West Virginia in the 1950s. Their mother, Lola, is absent, while their aunt, Nonie, raises them as her own, and Termite’s father, Corporal Robert Leavitt, is caught up in the early days of the Korean War. Told with deep feeling, the novel invites us deep into the hearts and thoughts of Lark, on the verge of adulthood, and her brother, Termite, a child unable to walk and talk, who is filled with radiance. We are also with Corporal Leavitt, trapped by friendly fire alongside the Korean children he tries to rescue. We see Lark’s dreams for Termite and her own future, and how, with the aid of a childhood love and a spectral social worker, she makes them happen. We learn of Lola’s love for her soldier husband and her children, and unravel the mystery of her relationship with Nonie. We discover the lasting connections between past and future on the night the town experiences an overwhelming flood, and we follow Lark and Termite as their lives are changed forever.

Author : Joseph Moninnger
Publisher : Simon and Schuster
ISBN 13 : 0731815416
Total Pages : 368 pages
Book Rating : 4.18/5 ( download)

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Download or read book Eternal on the Water written by Joseph Moninnger and published by Simon and Schuster. This book was released on 2011-08-01 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the day Cobb and Mary meet kayaking on Maine's Allagash River and fall deeply in love, the two approach life with the same sense of adventure they use to conquer the river's treacherous rapids. But rivers do not let go so easily...and neither does their love. So when Mary's life takes the cruelest turn, she vows to face those rough waters on her own terms and asks Cobb to promise, when the time comes, to help her return to their beloved river for one final journey. Set against the rugged wilderness of Maine, the exotic islands of Indonesia, the sweeping panoramas of Yellowstone National Park, and the tranquil villages of rural New England, Eternal on the Wateris at once heartbreaking and uplifting -- a timeless, beautifully rendered story of true love's power.

Author : Dean Koontz
Publisher : Penguin
ISBN 13 : 1101525363
Total Pages : 280 pages
Book Rating : 4.64/5 ( download)

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Download or read book The Eyes of Darkness written by Dean Koontz and published by Penguin. This book was released on 2011-04-05 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: A mother’s greatest wish—or worst nightmare—comes true in this chilling novel by #1 New York Times bestselling author Dean Koontz. Tina Evans has spent a year suffering from incredible heartache since her son Danny's tragic death. But now, with her Vegas show about to premiere, Tina can think of no better time for a fresh start. Maybe she can finally move on and put her grief behind her. Only there is a message for Tina, scrawled on the chalkboard in Danny's room: NOT DEAD. Two words that send her on a terrifying journey from the bright lights of Las Vegas to the cold shadows of the High Sierras, where she uncovers a terrible secret...

Author : Megan Abbott
Publisher : Reagan Arthur Books
ISBN 13 : 9780316175098
Total Pages : 256 pages
Book Rating : 4.99/5 ( download)

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Download or read book The End of Everything written by Megan Abbott and published by Reagan Arthur Books. This book was released on 2011-07-07 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thirteen-year old Lizzie Hood and her next door neighbor Evie Verver are inseparable. They are best friends who swap bathing suits and field-hockey sticks, and share everything that's happened to them. Together they live in the shadow of Evie's glamorous older sister Dusty, who provides a window on the exotic, intoxicating possibilities of their own teenage horizons. To Lizzie, the Verver household, presided over by Evie's big-hearted father, is the world's most perfect place. And then, one afternoon, Evie disappears. The only clue: a maroon sedan Lizzie spotted driving past the two girls earlier in the day. As a rabid, giddy panic spreads through the Midwestern suburban community, everyone looks to Lizzie for answers. Was Evie unhappy, troubled, upset? Had she mentioned being followed? Would she have gotten into the car of a stranger? Lizzie takes up her own furtive pursuit of the truth, prowling nights through backyards, peering through windows, pushing herself to the dark center of Evie's world. Haunted by dreams of her lost friend and titillated by her own new power at the center of the disappearance, Lizzie uncovers secrets and lies that make her wonder if she knew her best friend at all.