Macrophages In Liver Disease

Author : Ruchi Bansal
Publisher : Frontiers Media SA
ISBN 13 : 2889660389
Total Pages : 178 pages
Book Rating : 4.84/5 ( download)

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Download or read book Macrophages in Liver Disease written by Ruchi Bansal and published by Frontiers Media SA. This book was released on 2020-10-08 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Anirban Ghosh
Publisher : BoD – Books on Demand
ISBN 13 : 9535131230
Total Pages : 174 pages
Book Rating : 4.36/5 ( download)

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Download or read book Biology of Myelomonocytic Cells written by Anirban Ghosh and published by BoD – Books on Demand. This book was released on 2017-05-10 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myelomonocytes are the multipotent cells in the stage of blood cell differentiation, which mainly comprise blood monocytes, tissue macrophages and subset of dendritic cells. Actually, their position and ability of judgement of the health of tissue or organ environment are the key initiators of tissue-specific immune response in a local and global fashion. Interestingly, the morpho-functional aspects of this group of cells vary to a wide range with their positional diversity. Their ability to communicate or represent the tissue microenvironment to the peripheral immune system and efficiency to engage the system to effector activation hold the key for a successful immune endeavour. The present volume shows some glimpses of such an extensive area of current immunology research.

Author : Chandrashekhar Gandhi
Publisher : Academic Press
ISBN 13 : 0128005440
Total Pages : 335 pages
Book Rating : 4.46/5 ( download)

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Download or read book Stellate Cells in Health and Disease written by Chandrashekhar Gandhi and published by Academic Press. This book was released on 2015-04-10 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.

Author : Hannelie Korf
Publisher : Frontiers Media SA
ISBN 13 : 2889633136
Total Pages : 189 pages
Book Rating : 4.35/5 ( download)

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Download or read book The Role of Myeloid-Derived Cells in the Progression of Liver Disease written by Hannelie Korf and published by Frontiers Media SA. This book was released on 2020-01-22 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.33/5 ( download)

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Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Author : M. Victoria Delpino
Publisher : Frontiers Media SA
ISBN 13 : 2889661660
Total Pages : 107 pages
Book Rating : 4.64/5 ( download)

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Download or read book Advances in Liver Inflammation and Fibrosis due to Infectious Diseases written by M. Victoria Delpino and published by Frontiers Media SA. This book was released on 2020-12-29 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Jenna Danielle Strickland
Publisher :
ISBN 13 :
Total Pages : 188 pages
Book Rating : 4.44/5 ( download)

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Download or read book Macrophage Polarization in Liver Disease written by Jenna Danielle Strickland and published by . This book was released on 2021 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: In severe cases of acetaminophen (APAP) overdose, acute liver injury rapidly progresses to acute liver failure (ALF), producing life threatening complications including, hepatic encephalopathy and multi-organ failure. Systemic levels of the proinflammatory cytokine interleukin-6 (IL-6) and the anti-inflammatory cytokine interleukin-10 (IL-10) are highest in ALF patients with the poorest prognosis. However, the mechanistic basis for dysregulation of these cytokines, and their association with outcome in ALF remains poorly defined. Standard experimental settings of APAP hepatotoxicity in mice (i.e., 300 mg/kg) do not recapitulate key features of ALF in critically ill patients, including impaired hepatocyte proliferation, kidney injury, evidence of hepatic encephalopathy (HE), and cytokine dysregulation. Further, in stark contrast to ALF patients, IL-6 and IL-10 limit liver injury, increase hepatocyte proliferation, and reduce mortality under these experimental conditions. Thus, to investigate cytokine dysregulation in true ALF, we used a robust experimental setting of failed liver repair after APAP overdose in which a high dose of APAP is administered. Under these experimental conditions, we detected high serum levels of several pro- and anti-inflammatory cytokines, including IL-6 and IL-10, and observed increased levels of PD-L1 on macrophages mimicking systemic inflammatory response syndrome (SIRS) that occurs in critically ill ALF patients. Further, cerebral blood flow was markedly reduced in these mice, recapitulating a key feature of hepatic encephalopathy in ALF patients. Remarkably, neutralization of IL-6 in this setting restored cerebral blood flow, reduced mortality, and normalized levels of IL-10 and PD-L1. Furthermore, neutralization of IL-6 increased levels of Gas6, the primary ligand for the receptor Axl, which our studies revealed is essential for protection of the hepatic sinusoidal vasculature from injury after APAP overdose. In addition, our studies demonstrated that macrophage-mediated clearance of necrotic cells was prevented in mice with ALF, but was restored by neutralization of IL-10. Lastly, our studies identified Kupffer cells (KCs), the resident macrophages of the liver, as a primary source of IL-6, IL-10 and PD-L1 in APAP-induced ALF, and demonstrated further that the transcriptional regulator, NFKBIZ, may be responsible for enhanced IL-6 production in ALF. Collectively, our studies reveal that exaggerated levels of IL-6 are detrimental in APAP-induced ALF in mice, and suggest that therapies aimed at reducing IL-6 levels in patients with APAP-induced ALF may be beneficial. Additionally, as a part of this dissertation, we have developed a high-throughput assay that can detect differentiation of proinflammatory macrophages into pro-repair macrophages for use as a drug screening platform to identify chemicals/drugs that stimulate this process. Drugs identified from this screen could ultimately be used to restore macrophage function and liver repair in patients with both acute and chronic forms of liver failure.

Author : Myriam Aouadi
Publisher : Humana
ISBN 13 : 9781071607060
Total Pages : 160 pages
Book Rating : 4.65/5 ( download)

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Download or read book Kupffer Cells written by Myriam Aouadi and published by Humana. This book was released on 2021-07-15 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a complete overview of kupffer cell biology, from isolation to phenotyping. Chapters guide readers through methods and protocols on phenotyping, including RNA sequencing, Mass cytometry and 3D microscopy, as well as gene manipulation in vivo, and disease models from fatty liver disease to cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Kupffer Cells: Methods and Protocols aims to ensure successful investigation of this growing field.

Author : Frederick J. Suchy
Publisher : Cambridge University Press
ISBN 13 : 1108911374
Total Pages : 875 pages
Book Rating : 4.75/5 ( download)

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Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.29/5 ( download)

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Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.