Liver Regeneration And Carcinogenesis

Author : Bozzano G Luisa
Publisher : Elsevier
ISBN 13 : 0080535542
Total Pages : 427 pages
Book Rating : 4.48/5 ( download)

DOWNLOAD NOW!

Download or read book Liver Regeneration and Carcinogenesis written by Bozzano G Luisa and published by Elsevier. This book was released on 1995-09-27 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because of its marked capacity to regenerate and the ability of chemical carcinogens and viruses to ready transform hepatocytes, the liver has been used extensively as a model for investigating the molecular mechanisms of cellular proliferation and carcinogenesis. Recently, striking advances have occured in the understanding of hepatocyte growth regulation and the manner in which chemical agents and viruses alter these normal growth regulatory pathways in liver carcinogenesis. This explosion of information has occured in a multitude of researh disciplines. This book brings together current findings in a coherent manner, from a molecular point of view. Three sections cover in detail the areas of liver regeneration, liver carcinogenesis, and liver tumor therapy. The contributors are pioneers and leaders in this field. * Logical organization of material in three detailed and comprehensive sections: liver regeneration, liver carcinogenesis, and liver tumor treatment * Contributors are pioneers and leaders in the field * There are currently no books on this subject on the market * Research focus is at the molecular level

Author : George G. Skouteris
Publisher : Springer Science & Business Media
ISBN 13 : 3642792154
Total Pages : 489 pages
Book Rating : 4.51/5 ( download)

DOWNLOAD NOW!

Download or read book Liver Carcinogenesis written by George G. Skouteris and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last years much attention has been given to the investigation of the roles of specific growth modulators acting on liver cell populations. HGF functions as a pleotropic factor in the liver as well as in other extrahepatic tissues. The hepatic stem cell compartment is thought to play a major role in liver tissue restoration. Mechanisms of cell growth and cell death of the liver are described in detail, with particular emphasis on apoptosis. The functions of HBV-pX protein and the roles of hepatitis B virus gene expression relation to hepatocellular carcinoma are discussed. Techniques for obtaining human and nonhuman hepatocytes and other liver cell types and for efficient transfer and expression of genes in hepatocytes and liver-derived cell lines are presented.

Author : D. Bernuau
Publisher : John Libbey Eurotext
ISBN 13 : 9780861963478
Total Pages : 180 pages
Book Rating : 4.74/5 ( download)

DOWNLOAD NOW!

Download or read book Liver Regeneration written by D. Bernuau and published by John Libbey Eurotext. This book was released on 1992 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents an approach to the hepatic physiology and multiple developments about cellular biology such as cell cycle regulation, growth factors and oncogenes.

Author : Nancy Lou Thompson
Publisher :
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.70/5 ( download)

DOWNLOAD NOW!

Download or read book Liver Regeneration and Carcinogenesis written by Nancy Lou Thompson and published by . This book was released on 1986 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Wolf-Dieter Kuhlmann
Publisher : Cuvillier Verlag
ISBN 13 : 3736967756
Total Pages : 94 pages
Book Rating : 4.55/5 ( download)

DOWNLOAD NOW!

Download or read book Cellular fluctuations, alpha-fetoprotein expression, and the question of stem cells in experimental liver regeneration and hepatocarcinogenesis written by Wolf-Dieter Kuhlmann and published by Cuvillier Verlag. This book was released on 2023-05-25 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocytes and bile ductular cells possess stem-like potential in restoring liver tissue. This was derived from rat and mouse injury models such as (a) partial hepatectomy by surgery; (b) acute carbon tetrachloride intoxication; © injuries by D-galactosamine (GalN) or by N-nitrosomorpholine (NNM); (d) experimental hepatocarcinogenesis with NNM using different doses. Liver parenchyma was restored by adult hepatocytes after partial hepatectomy as well as after carbon tetrachloride intoxication. Concurrently, hepatocytes resumed synthesis of alpha-1-fetoprotein (AFP) which depended to a high degree on the animal species and strains used in that studies. In contrast to this way of regeneration, liver repair after heavy injuries by agents such as GalN and NNM was initiated by oval cell proliferation deriving from ductular epithelial cells of the canaliculi of HERING (canals of Hering, intrahepatic bile ductules) as sources of endogenous progenitors. Progenitor populations reach levels of differentiation with fetal gene reactivation and significant AFP expression. Proliferating oval cells operated as transit and amplification compartment during liver regeneration. Oval cell proliferation and concurrent AFP synthesis occurred also in the early stages of hepatocarcinogenesis when the carcinogen NNM was applied in toxic doses. The histologic features compared to those seen in GalN intoxication. NNM carcinogenicity was of concern for both oval cells and adult hepatocytes with risks of transformation and malignant development. At the cancer stage, carcinomas either synthesizing AFP or not can be found side by side in the same liver. AFP expression by cancer cells seems to be a special attribute to differentiation stages in carcinogenesis. Clonality, maturation arrest and retro-differentiation feature cells with high autonomy.

Author : W.E. Fleig
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387480
Total Pages : 268 pages
Book Rating : 4.81/5 ( download)

DOWNLOAD NOW!

Download or read book Normal and Malignant Liver Cell Growth written by W.E. Fleig and published by Springer Science & Business Media. This book was released on 1998-12-31 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although cell turnover in normal adult liver is extremely low, hepatic tissue is notorious for its almost infinite capacity to regenerate in cases of viral, toxic or traumatic damage. Hepatocellular carcinoma is one of the most frequent malignancies worldwide and causes more than a million deaths per year. The mechanisms governing normal proliferation and malignant transformation of liver cells are of utmost interest for the understanding of regeneration and hepatocarcinogenesis and for the development of new therapeutic strategies. Therefore, the International Falk Workshop held in Halle, Germany, on January 29-30 1998, focused on the issues of normal and malignant liver cell growth. Knowledge in this area of research has expanded rapidly during recent years. This book of proceedings summarizes the latest advances both in basic science and clinical research. Stimulating discussion set the basis for the development of new strategies in diagnosis and treatment of hepatocellular carcinoma and for the manipulation of regeneration in cases of acute or chronic loss of functional liver tissue.

Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.33/5 ( download)

DOWNLOAD NOW!

Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.29/5 ( download)

DOWNLOAD NOW!

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Author : Michele Claire Goyette
Publisher :
ISBN 13 :
Total Pages : 84 pages
Book Rating : 4.76/5 ( download)

DOWNLOAD NOW!

Download or read book Activation of Cellular Oncogenes During Liver Regeneration and Chemical Carcinogenesis written by Michele Claire Goyette and published by . This book was released on 1983 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Udayan M. Apte
Publisher : Academic Press
ISBN 13 : 0128004312
Total Pages : 326 pages
Book Rating : 4.19/5 ( download)

DOWNLOAD NOW!

Download or read book Liver Regeneration written by Udayan M. Apte and published by Academic Press. This book was released on 2015-08-13 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications presents cutting-edge information on liver regeneration research through an integrated, systems-wide perspective. The book addresses discoveries on hepatic progenitor cells, liver regeneration after chemical damage, and liver regeneration as a prime therapy for liver failure and disease. By addressing the urgent need for translating basic research findings into clinically relevant modalities and potential therapeutic applications, the book provides the data needed to improve liver patient management. Hundreds of full-color, graphic photographs and illustrations underline key elements and show researchers and students important aspects of liver transplantation, immunofluorescence, and other techniques used in liver regeneration. Summarizes current liver regeneration studies and discussions on expected discoveries Provides an overview of standard scientific and cutting-edge technologies to study liver regeneration Presents details on the molecular mechanisms that affect liver regeneration Highly illustrated, with hundreds of full-color, graphic photographs and illustrations to enhance the learning process