Lectures On Statistical Physics And Protein Folding

Author : Kerson Huang
Publisher : World Scientific
ISBN 13 : 9812561439
Total Pages : 159 pages
Book Rating : 4.35/5 ( download)

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Download or read book Lectures on Statistical Physics and Protein Folding written by Kerson Huang and published by World Scientific. This book was released on 2005 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestion on possible research directions, as developed by the author in collaboration with C. C. Lin. The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes. The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix.

Author : Alexei V. Finkelstein
Publisher : Elsevier
ISBN 13 : 0081012365
Total Pages : 528 pages
Book Rating : 4.69/5 ( download)

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Download or read book Protein Physics written by Alexei V. Finkelstein and published by Elsevier. This book was released on 2016-06-22 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states. The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins. New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding. Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry. Fully revised and expanded new edition based on the latest research developments in protein physics Written by the world's top expert in the field Deals with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states Summarizes, in a systematic form, the results of several decades of worldwide fundamental research on protein physics and their structure and folding Examines experimental data on protein structure in the post-genome era

Author : Nikolay Perunov
Publisher :
ISBN 13 :
Total Pages : 128 pages
Book Rating : 4.93/5 ( download)

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Download or read book Statistical Physics of Biological Self-organization written by Nikolay Perunov and published by . This book was released on 2016 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, we use the methods of statistical physics to provide quantitative insights into the behavior of biological systems. In the first half of the thesis, we use equilibrium statistical physics to develop a phenomenological model of how the hydrophobic effect impacts the structure of proteins, and in the second half, we study the phenomenon of adaptation and Darwinian selection from the standpoint of nonequilibrium statistical physics. It has been known for a long time that the hydrophobic effect plays a major role in driving protein folding. However, it has been challenging to translate this understanding into a predictive, quantitative theory of how the full pattern of sequence hydrophobicity in a protein helps to determine its structure. Here, we develop and apply a phenomenological theory of the sequence-structure relationship in globular protein domains. In an effort to optimize parameters for the model, we first analyze the patterns of backbone burial found in single-domain crystal structures and discover that classic hydrophobicity scales derived from bulk physicochemical properties of amino acids are already nearly optimal for prediction of burial using the model. Subsequently, we apply the model to studying structural fluctuations in proteins and establish a means of identifying ligand-binding and protein-protein interaction sites using this approach. In the second half of the thesis, we undertake to address the question of adaptation from the standpoint of physics. Building on past fundamental results in nonequilibrium statistical mechanics, we demonstrate a generalization of the Helmholtz free energy for the finite-time stochastic evolution of driven Newtonian matter. By analyzing this expression, we show a general tendency in a broad class of driven many-particle systems toward self-organization into states formed through reliable absorption and dissipation of work energy from the surrounding environment. We demonstrate how this tendency plays out in the familiar example of Darwinian competition between two exponentially growing self-replicators. Subsequently, we illustrate the more general mechanism by which extra dissipation drives adaptation by analyzing the process of random hopping in driven energy landscapes.

Author : Giorgio Favrin
Publisher :
ISBN 13 : 9789162860738
Total Pages : 118 pages
Book Rating : 4.39/5 ( download)

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Download or read book Statistical Physics of Protein Folding and Aggregation written by Giorgio Favrin and published by . This book was released on 2004 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Daniel M. Zuckerman
Publisher : CRC Press
ISBN 13 : 1420073796
Total Pages : 356 pages
Book Rating : 4.99/5 ( download)

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Download or read book Statistical Physics of Biomolecules written by Daniel M. Zuckerman and published by CRC Press. This book was released on 2010-06-02 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the hydrophobic effect to protein-ligand binding, statistical physics is relevant in almost all areas of molecular biophysics and biochemistry, making it essential for modern students of molecular behavior. But traditional presentations of this material are often difficult to penetrate. Statistical Physics of Biomolecules: An Introduction brin

Author : Sebastian Doniach
Publisher : Springer Science & Business Media
ISBN 13 : 1489913491
Total Pages : 400 pages
Book Rating : 4.94/5 ( download)

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Download or read book Statistical Mechanics, Protein Structure, and Protein Substrate Interactions written by Sebastian Doniach and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of factors have come together in the last couple of decades to define the emerging interdisciplinary field of structural molecular biology. First, there has been the considerable growth in our ability to obtain atomic-resolution structural data for biological molecules in general, and proteins in particular. This is a result of advances in technique, both in x-ray crystallography, driven by the development of electronic detectors and of synchrotron radiation x-ray sources, and by the development ofNMR techniques which allow for inference of a three-dimensional structure of a protein in solution. Second, there has been the enormous development of techniques in DNA engineering which makes it possible to isolate and clone specific molecules of interest in sufficient quantities to enable structural measurements. In addition, the ability to mutate a given amino acid sequence at will has led to a new branch of biochemistry in which quantitative measurements can be made assessing the influence of a given amino acid on the function of a biological molecule. A third factor, resulting from the exponential increase in computing power available to researchers, has been the emergence of a growing body of people who can take the structural data and use it to build atomic-scale models of biomolecules in order to try and simulate their motions in an aqueous environment, thus helping to provide answers to one of the most basic questions of molecular biology: the relation of structure to function.

Author : Giancarlo Franzese
Publisher : Springer
ISBN 13 : 3540787658
Total Pages : 236 pages
Book Rating : 4.55/5 ( download)

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Download or read book Aspects of Physical Biology written by Giancarlo Franzese and published by Springer. This book was released on 2008-12-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application to Biology of the methodologies developed in Physics is attracting an increasing interest from the scientific community. It has led to the emergence of a new interdisciplinary field, called Physical Biology, with the aim of reaching a better understanding of the biological mechanisms at molecular and cellular levels. Statistical Mechanics in particular plays an important role in the development of this new field. For this reason, the XXth session of the famous Sitges Conference on Statistical Physics was dedicated to "Physical Biology: from Molecular Interactions to Cellular Behavior". As is by now tradition, a number of lectures were subsequently selected, expanded and updated for publication as lecture notes, so as to provide both a state-of-the-art introduction and overview to a number of subjects of broader interest and to favor the interchange and cross-fertilization of ideas between biologists and physicists. The present volume focuses on three main subtopics (biological water, protein solutions as well as transport and replication), presenting for each of them the on-going debates on recent results. The role of water in biological processes, the mechanisms of protein folding, the phases and cooperative effects in biological solutions, the thermodynamic description of replication, transport and neural activity, all are subjects that are revised in this volume, based on new experiments and new theoretical interpretations.

Author : Hamid Arabnia
Publisher : Springer Science & Business Media
ISBN 13 : 1441970460
Total Pages : 776 pages
Book Rating : 4.66/5 ( download)

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Download or read book Software Tools and Algorithms for Biological Systems written by Hamid Arabnia and published by Springer Science & Business Media. This book was released on 2011-03-23 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Software Tools and Algorithms for Biological Systems" is composed of a collection of papers received in response to an announcement that was widely distributed to academicians and practitioners in the broad area of computational biology and software tools. Also, selected authors of accepted papers of BIOCOMP’09 proceedings (International Conference on Bioinformatics and Computational Biology: July 13-16, 2009; Las Vegas, Nevada, USA) were invited to submit the extended versions of their papers for evaluation.

Author : Sauro Succi
Publisher : Oxford University Press
ISBN 13 : 0192897896
Total Pages : 401 pages
Book Rating : 4.93/5 ( download)

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Download or read book Sailing the Ocean of Complexity written by Sauro Succi and published by Oxford University Press. This book was released on 2022 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Both superb and essential... Succi, with clarity and wit, takes us from quarks and Boltzmann to soft matter - precisely the frontier of physics and life." Stuart Kauffman, MacArthur Fellow, Fellow of the Royal Society of Canada, Gold Medal Accademia Lincea We live in a world of utmost complexity, outside and within us. There are thousand of billions of billions of stars out there in the Universe, a hundred times more molecules in a glass of water, and another hundred times more in our body, all working in sync to keep us alive and well. At face value, such numbers spell certain doom for our ability to make any sense at all of the world around and within us. And yet, they don't. Why, and how - this book endeavours to provide an answer to these questions with specific reference to a selected window of the physics-biology interface. The story unfolds over four main Parts. Part I provides an introduction to the main organizational principles which govern the functioning of complex systems in general, such as nonlinearity, nonlocality and ultra-dimensions. Part II deals with thermodynamics, the science of change, starting with its historical foundations laid down in the 19th century, and then moving on to its modern and still open developments in connection with biology and cosmology. Part III deals with the main character of this book, free energy, and the wondrous scenarios opened up by its merger with the modern tools of statistical physics. It also describes the basic facts about soft matter, the state of matter most relevant to biological organisms. Finally, Part IV discusses the connection between time and complexity, and its profound implications on the human condition, i.e. the one-sided nature of time and the awareness of human mortality. It concludes with a few personal considerations about the special place of emotions and humility in science.

Author : Giovanni Naldi
Publisher : Springer Science & Business Media
ISBN 13 : 0817649468
Total Pages : 437 pages
Book Rating : 4.63/5 ( download)

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Download or read book Mathematical Modeling of Collective Behavior in Socio-Economic and Life Sciences written by Giovanni Naldi and published by Springer Science & Business Media. This book was released on 2010-08-12 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using examples from finance and modern warfare to the flocking of birds and the swarming of bacteria, the collected research in this volume demonstrates the common methodological approaches and tools for modeling and simulating collective behavior. The topics presented point toward new and challenging frontiers of applied mathematics, making the volume a useful reference text for applied mathematicians, physicists, biologists, and economists involved in the modeling of socio-economic systems.