Kidney Inflammation Injury And Regeneration 2020

Author : Patrick C. Baer
Publisher : MDPI
ISBN 13 : 3039285386
Total Pages : 496 pages
Book Rating : 4.89/5 ( download)

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Download or read book Kidney Inflammation, Injury and Regeneration written by Patrick C. Baer and published by MDPI. This book was released on 2020-04-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.

Author : Patrick C Baer
Publisher : Mdpi AG
ISBN 13 : 9783036523705
Total Pages : 318 pages
Book Rating : 4.07/5 ( download)

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Download or read book Kidney Inflammation, Injury and Regeneration 2020 written by Patrick C Baer and published by Mdpi AG. This book was released on 2021-11-23 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of chronic kidney disease in the sequel. Whereas the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function-in both the short- and long-term-is urgently needed. This Special Issue includes papers investigating the pathological mechanisms of renal inflammation and AKI and diagnostics using new biomarkers. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate kidney dysfunction are included, as well as review articles.

Author : Patrick C. Baer
Publisher :
ISBN 13 : 9783039285396
Total Pages : 496 pages
Book Rating : 4.94/5 ( download)

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Download or read book Kidney Inflammation, Injury and Regeneration written by Patrick C. Baer and published by . This book was released on 2020 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.

Author : Patrick C. Baer
Publisher :
ISBN 13 : 9783036523699
Total Pages : 318 pages
Book Rating : 4.93/5 ( download)

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Download or read book Kidney Inflammation, Injury and Regeneration 2020 written by Patrick C. Baer and published by . This book was released on 2021 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of chronic kidney disease in the sequel. Whereas the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function--in both the short- and long-term--is urgently needed. This Special Issue includes papers investigating the pathological mechanisms of renal inflammation and AKI and diagnostics using new biomarkers. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate kidney dysfunction are included, as well as review articles.

Author : Yoshio Terada
Publisher : Springer Nature
ISBN 13 : 981151108X
Total Pages : 390 pages
Book Rating : 4.80/5 ( download)

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Download or read book Acute Kidney Injury and Regenerative Medicine written by Yoshio Terada and published by Springer Nature. This book was released on 2020-05-14 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis.Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.

Author : Manuela Ghielli
Publisher :
ISBN 13 :
Total Pages : 209 pages
Book Rating : 4.99/5 ( download)

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Download or read book Role of Inflammatory Cells on Injury and Regeneration of the Kidney written by Manuela Ghielli and published by . This book was released on 1999 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Vladimir T. Todorov
Publisher : Frontiers Media SA
ISBN 13 : 2832523994
Total Pages : 119 pages
Book Rating : 4.95/5 ( download)

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Download or read book Recent advances on renoprotection and kidney regeneration written by Vladimir T. Todorov and published by Frontiers Media SA. This book was released on 2023-05-25 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Simon Steddon
Publisher : Oxford University Press
ISBN 13 : 0199651612
Total Pages : 1002 pages
Book Rating : 4.10/5 ( download)

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Download or read book Oxford Handbook of Nephrology and Hypertension written by Simon Steddon and published by Oxford University Press. This book was released on 2014-03 with total page 1002 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the Oxford Textbook of Clinical Nephrology and companion to the Oxford Handbook of Dialysis, this handbook provides clear information and practical advice about the day-to-day management of patients with renal disease.

Author : Jong Hoon Park
Publisher : Springer
ISBN 13 : 9811020418
Total Pages : 128 pages
Book Rating : 4.14/5 ( download)

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Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Author : Z.-H. Liui
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318026514
Total Pages : 274 pages
Book Rating : 4.11/5 ( download)

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Download or read book Podocytopathy written by Z.-H. Liui and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-16 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.