Iron Physiology And Pathophysiology In Humans

Author : Gregory J. Anderson
Publisher : Springer Science & Business Media
ISBN 13 : 1603274847
Total Pages : 705 pages
Book Rating : 4.45/5 ( download)

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Download or read book Iron Physiology and Pathophysiology in Humans written by Gregory J. Anderson and published by Springer Science & Business Media. This book was released on 2012-01-16 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.

Author : Rosalia Kripke
Publisher : American Medical Publishers
ISBN 13 : 9781639277087
Total Pages : 0 pages
Book Rating : 4.80/5 ( download)

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Download or read book Physiology and Pathophysiology of Iron in Humans written by Rosalia Kripke and published by American Medical Publishers. This book was released on 2023-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: For human beings, iron is an important trace element. It is required for various bodily processes such as cell growth and division, oxygen transport, various catalytic reactions, and oxidative metabolism. Human body requires only a small amount of iron on a daily basis. It must be consumed in a strictly monitored manner because there is no mechanism for excreting excess iron out of the body. Erythropoiesis, i.e., the production of new blood cells, takes place in the bone marrow, which is the major consumer of iron. The reticuloendothelial system helps in recycling iron by erythrocyte phagocytosis. Various proteins are involved in iron metabolism. For instance, hepcidin is a liver-derived peptide hormone that works as a major regulator of iron metabolism. This book explores all the important aspects of the physiology and pathophysiology of iron in the present day scenario. It is a valuable compilation of topics, ranging from the basic to the most complex advancements. Those in search of information to further their knowledge will be greatly assisted by this book.

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 9780309072793
Total Pages : 804 pages
Book Rating : 4.94/5 ( download)

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Download or read book Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc written by Institute of Medicine and published by National Academies Press. This book was released on 2002-07-19 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.

Author : Randall B. Lauffer
Publisher : CRC Press
ISBN 13 : 9780849367793
Total Pages : 554 pages
Book Rating : 4.94/5 ( download)

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Download or read book Iron and Human Disease written by Randall B. Lauffer and published by CRC Press. This book was released on 1992-08-05 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron and Human Disease is the first book to cover the three key aspects of human iron metabolism: the accumulation of iron in adults, iron as a limiting factor for tumor and infectious cell growth, and iron as a catalyst for oxygen free radical production. The book describes the hypotheses and findings related to the role of iron in cardiovascular disease (including reperfusion injury), cancer, aging, and autoimmune and neurodegenerative diseases. Other topics covered include the molecular biology and biochemistry of iron, the general principles governing iron balance, iron in the immune system and acute phase response, and new preventive and therapeutic strategies. Iron and Human Disease will be a useful reference for biomedical investigators, physicians, nutritionists, and public health officials.

Author : Robert Crichton
Publisher : John Wiley & Sons
ISBN 13 : 9780470010297
Total Pages : 484 pages
Book Rating : 4.90/5 ( download)

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Download or read book Iron Metabolism written by Robert Crichton and published by John Wiley & Sons. This book was released on 2009-02-25 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage, and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in humans; the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well established role in infections by a range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism. Iron overloads and deficiencies are important factors in the health of humans and are therefore a key target in drug development. Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, 3rd Edition presents a comprehensive overview of this important field.Topics covered include: Solution chemistry of iron in biological media The importance of iron for biological systems Microbial iron transport and metabolism Iron uptake by plants and fungi Cellular iron uptake and export in mammals Intracellular iron storage and biomineralization Intracellular iron metabolism and cellular iron homeostasis Iron absorption in mammals, with particular reference to man, and regulation of systemic iron balance Pathophysiology of iron deficiency and iron overload in man Iron and oxidative stress Brain iron homeostasis and its perturbation in various neurodegenerative diseases Interactions between iron and other metals Written in a lively style by one of the leaders in the field and presented in full colour, this third, expanded edition of Iron Metabolism has been fully updated with the latest discoveries. Major additions include recent information on mitochondrial iron metabolism and the role of frataxin; transcriptional control of iron homeostasis; orally active iron chelators; the roles of hepcidin and erythropoietin; the increasing number of types of iron overload; and the importance of iron in Alzheimer’s disease. Iron Metabolism is essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and the medical sciences. It will also find space on the bookshelves of bioinorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, and pharmacologists in the pharmaceutical industry interested in developing novel iron-binding drugs.

Author : Dietmar Enko
Publisher : Mdpi AG
ISBN 13 : 9783036595900
Total Pages : 0 pages
Book Rating : 4.02/5 ( download)

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Download or read book Physiology and Pathophysiology of Iron Metabolism written by Dietmar Enko and published by Mdpi AG. This book was released on 2023-12-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reprint focuses on the importance of the micronutrient iron in human physiological iron homeostasis and iron-related diseases. Daily adequate dietary iron supply ensures vital body functions and hemoglobin synthesis during erythropoiesis. During the last few decades, scientific evidence has shown that the maintenance of human iron homeostasis is an important factor for physical and mental health. The present reprint gives an overview of how iron, as an essential dietary element, is responsible for physiological and pathological biochemical processes in the human body. For the readership, this relevant information will provide an evidence-based update on the complex regulatory mechanisms and related diseases of iron metabolism.

Author : Chaim Hershko
Publisher : Springer Science & Business Media
ISBN 13 : 1461525543
Total Pages : 394 pages
Book Rating : 4.47/5 ( download)

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Download or read book Progress in Iron Research written by Chaim Hershko and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4th International Conference on Hemochromatosis and the 11th International Conference on Iron and Iron Proteins took place in Jerusalem on April 27 -30 and on May 2 -7 1993, respectively. The first, a clinical meeting, and the second, a forum designed primarily for basic scientists. Both meetings are held regularly on alter nate years and represent probably the most important forum for the exchange of information in iron research. The present volume "Progress in Iron Research" is based on a selection of presentations delivered at these meetings. However, this volume represents much more than a publication of conference proceedings. It offers a comprehensive state-of-the-art review on most aspects of iron metabolism. We have tried to offer a balanced review of the most important recent developments in iron research including both basic research and clinical investigation. However, the scope of chapters was based, by definition, on the actual participants at the meetings and some important fields in iron research such as plant physiology, microbial aspects of iron metabolism, and free radical research have not been dealt with. Many of the authors of the 40 chapters have beel). pt1rsonally responsible for some of the most important developments in iron research ~~vidffig: n~~~ights into iron physiology and pathophysiology. The Editors wish to express their gratitude for the outstanding and timely cooperation of all contributors to this volume.

Author : Yan-Zhong Chang
Publisher : Springer Nature
ISBN 13 : 9811395896
Total Pages : 194 pages
Book Rating : 4.95/5 ( download)

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Download or read book Brain Iron Metabolism and CNS Diseases written by Yan-Zhong Chang and published by Springer Nature. This book was released on 2019-08-27 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.

Author : Marco Malavolta
Publisher : Springer
ISBN 13 : 3030037428
Total Pages : 328 pages
Book Rating : 4.20/5 ( download)

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Download or read book Trace Elements and Minerals in Health and Longevity written by Marco Malavolta and published by Springer. This book was released on 2018-11-13 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, and e) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals.

Author : Chaim Hershko
Publisher : Springer Science & Business Media
ISBN 13 : 1461505933
Total Pages : 275 pages
Book Rating : 4.38/5 ( download)

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Download or read book Iron Chelation Therapy written by Chaim Hershko and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).