Interindividual Variability In Human Drug Metabolism

Author : Gian Maria Pacifici
Publisher : CRC Press
ISBN 13 : 9780748408641
Total Pages : 560 pages
Book Rating : 4.49/5 ( download)

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Download or read book Interindividual Variability in Human Drug Metabolism written by Gian Maria Pacifici and published by CRC Press. This book was released on 2001-05-24 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of drug metabolism in vivo: variability of psychotropic drugs, antiepileptic drugs, the dopamine precursor levodopa, cardiovascular active drugs and anti HIV drugs. Seven chapters address the interindividual variability of the main drug metabolizing enzymes: CYP-450s, acetyltransferases, glucuronosyl transferase, methyl transferases, sulfotransferases and glutathione transferases in human liver and extrahepatic tissues. A separate chapter discusses the prediction of drug interaction. Comprehensive in coverage, and with contributions from the leading international experts, this book is essential reading for researchers from both academia and the pharmaceutical industry. Advanced undergraduates and postgraduates in pharmacology, clinical pharmacology, toxicology, biochemistry and epidemiology who are interested in drug metabolism will also find this an indispensable resource.

Author : Stephen E. Smith
Publisher : Elsevier
ISBN 13 : 1483165116
Total Pages : 181 pages
Book Rating : 4.10/5 ( download)

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Download or read book Variability in Human Drug Response written by Stephen E. Smith and published by Elsevier. This book was released on 2013-10-22 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Variability in Human Drug Response examines why individual patients differ significantly in their response to drug administration. This book is devoted mainly to pharmacokinetics and covers topics such as drug absorption, distribution, metabolism, and excretion. The sensitivity of tissues of the body to drugs and the importance of monitoring drug therapy are also discussed. This book is comprised of 10 chapters and begins with an introduction to variability in clinical response to administration of defined drugs, as well as the importance of closely matching dosage to the individual patient's requirement to achieve an optimal response to drug administration. The chapters that follow highlight the pharmacokinetic origin of most variability in the clinical response to drugs, along with the difficulties inherent in predicting the effect of drug administration in an individual patient. The role of genetic and environmental factors, disease, and the concomitant administration of other drugs in determining an individual's response to any therapeutic maneuver is also examined. The last chapter describes two methods of monitoring drug therapy: monitoring drug effects or monitoring the plasma levels of drugs. This monograph will be of interest to practicing clinicians and senior medical students.

Author : Fundación Dr. Antonio Esteve. Symposium
Publisher : Elsevier Science & Technology
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.12/5 ( download)

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Download or read book Variability in Human Drug Response written by Fundación Dr. Antonio Esteve. Symposium and published by Elsevier Science & Technology. This book was released on 1999 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. Variability in Human Drug Response represents a comprehensive account of the information shared by the participants of the Esteve Foundation's Eight Symposium held in Sitges, Spain. The Esteve Foundation which operates independently of any pharmaceutical enterprise, organizes international multidisciplinary meetings like The Esteve Foundation Symposia whose main goal is to stimulate progress in pharmacotherapy through scientific communication and discussion. The 8th symposium provided a timely forum which took into account the many aspects of variability in human drug response. The fact that every patient is different indicates the reason why the art and science of medical diagnosis is so interesting. The diversity in treatment can be viewed both as a challenge and as an obstacle. Clinical pharmacologists have been dealing with the challenge of understanding the many sources of variability in drug responses. With the advent of mo

Author : Kewal K. Jain
Publisher : Humana Press
ISBN 13 : 1493925539
Total Pages : 762 pages
Book Rating : 4.37/5 ( download)

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Download or read book Textbook of Personalized Medicine written by Kewal K. Jain and published by Humana Press. This book was released on 2015-03-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

Author :
Publisher : Academic Press
ISBN 13 : 0128137975
Total Pages : 378 pages
Book Rating : 4.70/5 ( download)

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Download or read book Chromatin Signaling and Neurological Disorders written by and published by Academic Press. This book was released on 2019-05-24 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-based therapies. A diverse range of chapters from international experts speaks to the basis of chromatin and epigenetic signaling pathways and specific chromatin signaling factors that regulate a range of diseases. In addition to the basic science of chromatin signaling factors, each disease-specific chapter speaks to the translational or clinical significance of recent findings, along with important implications for the development of epigenetics-based therapeutics. Common themes of translational significance are also identified across disease types, as well as the future potential of chromatin signaling research. Examines specific chromatin signaling factors that regulate spinal muscular atrophy, ulbospinal muscular atrophy, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, multiple sclerosis, Angelman syndrome, Rader-Willi syndrome, and more Contains chapter contributions from international experts who speak to the clinical significance of recent findings and the implications for the development of epigenetics-based therapeutics Provides researchers, students and clinicians with approaches to better interpret and employ new diagnostic studies for treating neurological disorders

Author : Jennifer B. Dressman
Publisher : CRC Press
ISBN 13 : 1420077341
Total Pages : 432 pages
Book Rating : 4.46/5 ( download)

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Download or read book Oral Drug Absorption written by Jennifer B. Dressman and published by CRC Press. This book was released on 2016-04-19 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an

Author : Stephen Edward Smith
Publisher : Butterworth-Heinemann
ISBN 13 : 9780407433014
Total Pages : 172 pages
Book Rating : 4.15/5 ( download)

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Download or read book Variability in Human Drug Response written by Stephen Edward Smith and published by Butterworth-Heinemann. This book was released on 1973 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Martin F. Fromm
Publisher : Springer Science & Business Media
ISBN 13 : 3642145418
Total Pages : 457 pages
Book Rating : 4.14/5 ( download)

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Download or read book Drug Transporters written by Martin F. Fromm and published by Springer Science & Business Media. This book was released on 2010-11-19 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Author : Albert P. Li
Publisher : John Wiley & Sons
ISBN 13 : 1119170842
Total Pages : 530 pages
Book Rating : 4.46/5 ( download)

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Download or read book Transporters and Drug-Metabolizing Enzymes in Drug Toxicity written by Albert P. Li and published by John Wiley & Sons. This book was released on 2021-07-27 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITY Explore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resources Transporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development – accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences. Mechanism and species differences in drug metabolizing enzymes and transporters are discussed, as are the methods used to investigate the role of drug metabolizing enzymes and transporters in drug toxicity. Finally, the distinguished authors describe promising new experimental approaches to accurately assessing human drug toxicity via the consideration of human-specific drug metabolism in toxicity assays. In addition to topics as diverse as extended clearance models, experimental approaches for the estimation of DILI potential of drug candidates and roles of transporters in renal drug toxicity, readers will also enjoy the inclusion of such subjects as: A thorough overview of and introduction to drug metabolism and transporters and drug toxicity An exploration of drug metabolism enzymes and transporter activities as risk factors of marketed drugs associated with drug-induced fatalities A discussion of human-based in vitro experimental models for the evaluation of metabolism-dependent drug toxicity A treatment of mechanism-based experimental models for the evaluation of BSEP inhibition and DILI An examination of transporters and cochlea toxicity Perfect for scientists, students, and practitioners with interests in metabolism, toxicology, and drug development in the pharmaceutical industry, Transporters and Drug-Metabolizing Enzymes in Drug Toxicity will also earn a place in the libraries of medicinal chemists, pharmacologists, biochemists, toxicologists, and regulators in the pharmaceutical and health industries.

Author : Mino R. Caira
Publisher : Springer Science & Business Media
ISBN 13 : 140204142X
Total Pages : 431 pages
Book Rating : 4.26/5 ( download)

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Download or read book Drug Metabolism written by Mino R. Caira and published by Springer Science & Business Media. This book was released on 2006-07-10 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.