Integrins In Health And Disease

Author : Donald Gullberg
Publisher : Springer Nature
ISBN 13 : 3031237811
Total Pages : 473 pages
Book Rating : 4.12/5 ( download)

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Download or read book Integrins in Health and Disease written by Donald Gullberg and published by Springer Nature. This book was released on 2023-03-10 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find “Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions” authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.81/5 ( download)

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Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Andreja Ambriovic-Ristov
Publisher : Frontiers Media SA
ISBN 13 : 2832517781
Total Pages : 252 pages
Book Rating : 4.89/5 ( download)

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Download or read book Integrin adhesion receptors in health and disease written by Andreja Ambriovic-Ristov and published by Frontiers Media SA. This book was released on 2023-03-17 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : David A. Cheresh
Publisher : Academic Press
ISBN 13 : 0121711609
Total Pages : 297 pages
Book Rating : 4.03/5 ( download)

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Download or read book Integrins written by David A. Cheresh and published by Academic Press. This book was released on 1994-09-26 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrins: Molecular and Biological Responses to the Extracellular Matrix will help basic, applied, and clinical researchers keep up with the explosion of literature on the integrin family of proteins. This volume extends material previously covered in Receptors for Extracellular Matrix. It addresses some of the most exciting areas of integrin biology, including the varied roles of integrins in cell division, differentiation, movement, wound healing, inflammation, thrombosis, osteoporosis, and cancer. Describes key aspects of integrin structure, function, and biology Covers collagen receptors, epithelial cell integrins, leukocyte integrins, platelet integrins, integrin signaling, and integrin antagonists Investigates the expression and role of integrins during development and in the cytoskeleton Includes the actions and influences of integrins in inflammation, thrombosis, and osteoporosis

Author : Paul
Publisher : CRC Press
ISBN 13 : 9780824798246
Total Pages : 784 pages
Book Rating : 4.44/5 ( download)

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Download or read book Adhesion Molecules in Health and Disease written by Paul and published by CRC Press. This book was released on 1997-05-16 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an overview of the structure, transcription regulation and binding characteristics of cellular adhesion molecules and their ligands in the maintenance of function, immunological reactions and inflammatory processes with organ systems. The text examines the role of adhesion molecules in biological processes such as morphogenesis, blood coagulation, tumour metastasis, bone tissue remodelling and transplant rejection.

Author : Vanadiya Ermekova
Publisher :
ISBN 13 : 9780595401451
Total Pages : 0 pages
Book Rating : 4.57/5 ( download)

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Download or read book Integrins & Anti-integrins written by Vanadiya Ermekova and published by . This book was released on 2006-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrins play a critical role in numerous vital processes on the systemic, tissue, cell, and molecular levels. These include homeostasis; immunity; hematopoiesis; fertility and embryogenesis; cell proliferation, differentiation, cell cycle division and apoptosis; and gene expression. Impairment of integrins' functions causes the dramatic remodeling of these processes. Prolonged therapy with anti-α4β antibodies may result in severe pathological consequences, including generalized immunosuppression leading to an extreme risk of very serious infections; uncontrolled proliferation and altered differentiation of hematopoietic cells possibly leading to hematological abnormalities and increased risk of malignancies; and alterations in spermatogenesis, fertility, and embryonic development. Natalizumab (Tysabri) is an impressively effective drug. In the professional opinion of well-known neurologists it is considered to be a promising agent for the treatment of multiple sclerosis. However, whereas the evaluation of the drug's benefits can be done by neurologists alone, it is mandatory that the risk in using this agent should be assessed by a team of experts in a number of fields: immunology, infectious diseases, hematology, oncology, and embryology. It is essential to recognize that innovative integrin-antagonist therapy, e.g. therapy with anti-α4β integrin monoclonal antibodies, must be handled with extreme caution.

Author : Shaker A. Mousa
Publisher :
ISBN 13 :
Total Pages : 276 pages
Book Rating : 4.17/5 ( download)

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Download or read book Cell Adhesion Molecules and Matrix Proteins written by Shaker A. Mousa and published by . This book was released on 1998 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Peter J. Barnes
Publisher : Elsevier
ISBN 13 : 0080920608
Total Pages : 897 pages
Book Rating : 4.03/5 ( download)

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Download or read book Asthma and COPD written by Peter J. Barnes and published by Elsevier. This book was released on 2009-03-19 with total page 897 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations

Author : Markus J. Seibel
Publisher : Elsevier
ISBN 13 : 9780080456263
Total Pages : 920 pages
Book Rating : 4.6X/5 ( download)

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Download or read book Dynamics of Bone and Cartilage Metabolism written by Markus J. Seibel and published by Elsevier. This book was released on 2006-07-24 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components Part II covers the organizational structure and cellular metabolism of bone and cartilage Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

Author : Julia Thom Oxford
Publisher : MDPI
ISBN 13 : 3038975702
Total Pages : 357 pages
Book Rating : 4.00/5 ( download)

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Download or read book Extracellular Matrix in Development and Disease written by Julia Thom Oxford and published by MDPI. This book was released on 2019-02-21 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Extracellular Matrix in Development and Disease" that was published in IJMS