Integrins Anti Integrins

Author : Vanadiya Ermekova
Publisher :
ISBN 13 : 9780595401451
Total Pages : 0 pages
Book Rating : 4.57/5 ( download)

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Download or read book Integrins & Anti-integrins written by Vanadiya Ermekova and published by . This book was released on 2006-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrins play a critical role in numerous vital processes on the systemic, tissue, cell, and molecular levels. These include homeostasis; immunity; hematopoiesis; fertility and embryogenesis; cell proliferation, differentiation, cell cycle division and apoptosis; and gene expression. Impairment of integrins' functions causes the dramatic remodeling of these processes. Prolonged therapy with anti-α4β antibodies may result in severe pathological consequences, including generalized immunosuppression leading to an extreme risk of very serious infections; uncontrolled proliferation and altered differentiation of hematopoietic cells possibly leading to hematological abnormalities and increased risk of malignancies; and alterations in spermatogenesis, fertility, and embryonic development. Natalizumab (Tysabri) is an impressively effective drug. In the professional opinion of well-known neurologists it is considered to be a promising agent for the treatment of multiple sclerosis. However, whereas the evaluation of the drug's benefits can be done by neurologists alone, it is mandatory that the risk in using this agent should be assessed by a team of experts in a number of fields: immunology, infectious diseases, hematology, oncology, and embryology. It is essential to recognize that innovative integrin-antagonist therapy, e.g. therapy with anti-α4β integrin monoclonal antibodies, must be handled with extreme caution.

Author : Anthony R. Howlett
Publisher : Springer Science & Business Media
ISBN 13 : 159259249X
Total Pages : 296 pages
Book Rating : 4.94/5 ( download)

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Download or read book Integrin Protocols written by Anthony R. Howlett and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Integrin Protocols, Anthony Howlett and a distinguished panel of experimentalists describe in detail a series of cutting-edge methods for dissecting the role of integrins in biological processes. This wide-ranging collection includes protocols for the analysis of integrin expression-at both the RNA and protein levels-and for elucidating the functional properties of integrins, including those at the cellular level. Each method provides step-by-step instructions for easy reproducibility, along with extensive notes about potential pitfalls, and tips on how to avoid failure. The emphasis is always on the practical steps necessary for experimental success and robust results. Offering powerful tools for understanding how integrins regulate cell growth, differentiation, migration, invasion, angiogenesis, and apoptosis, as well as how abnormalities of integrin expression and function may be implicated in various pathologic conditions, Integrin Protocols constitutes a gold-standard collection of techniques for both new and experienced investigators of the molecular and cellular basis of cardiovascular disease, inflammatory disorders, and cancer.

Author :
Publisher : Elsevier
ISBN 13 : 0080917291
Total Pages : 297 pages
Book Rating : 4.90/5 ( download)

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Download or read book Integrins written by and published by Elsevier. This book was released on 2012-12-02 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrins: Molecular and Biological Responses to the Extracellular Matrix will help basic, applied, and clinical researchers keep up with the explosion of literature on the integrin family of proteins. This volume extends material previously covered in Receptors for Extracellular Matrix. It addresses some of the most exciting areas of integrin biology, including the varied roles of integrins in cell division, differentiation, movement, wound healing, inflammation, thrombosis, osteoporosis, and cancer. Describes key aspects of integrin structure, function, and biology Covers collagen receptors, epithelial cell integrins, leukocyte integrins, platelet integrins, integrin signaling, and integrin antagonists Investigates the expression and role of integrins during development and in the cytoskeleton Includes the actions and influences of integrins in inflammation, thrombosis, and osteoporosis

Author : Donald Gullberg
Publisher : Springer Nature
ISBN 13 : 3031237811
Total Pages : 473 pages
Book Rating : 4.12/5 ( download)

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Download or read book Integrins in Health and Disease written by Donald Gullberg and published by Springer Nature. This book was released on 2023-03-10 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find “Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions” authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Author : Adam S. Cheifetz
Publisher : Springer
ISBN 13 : 9783319602752
Total Pages : 0 pages
Book Rating : 4.56/5 ( download)

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Download or read book Treatment of Inflammatory Bowel Disease with Biologics written by Adam S. Cheifetz and published by Springer. This book was released on 2017-11-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohn’s disease and ulcerative colitis. The volume details how best to utilize these medications in order to optimize their efficacy and safety, as well as how to understand, recognize, and treat complications that may arise from using biologics to treat IBD. The text also focuses on new data, novel biologics, and biosimilars of this rapidly expanding field. Written by experts in the field, Treatment of Inflammatory Bowel Disease with Biologics is a valuable resource for gastroenterologists, allied health professionals, fellows, and trainees who treat patients with inflammatory bowel disease.

Author : Andrea Becchetti
Publisher : Springer Science & Business Media
ISBN 13 : 144196066X
Total Pages : 138 pages
Book Rating : 4.65/5 ( download)

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Download or read book Integrins and Ion Channels written by Andrea Becchetti and published by Springer Science & Business Media. This book was released on 2010-12-28 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464956448
Total Pages : 30 pages
Book Rating : 4.47/5 ( download)

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Download or read book Integrins: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrins: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Integrins in a compact format. The editors have built Integrins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Integrins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Integrins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Erik H.J. Danen
Publisher : CRC Press
ISBN 13 : 1498712983
Total Pages : 234 pages
Book Rating : 4.89/5 ( download)

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Download or read book Integrins and Development written by Erik H.J. Danen and published by CRC Press. This book was released on 2006-05-12 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell adhesion is essential for the organization of multicellular organisms. Indeed, various types of cell adhesion receptors, including cadherins and integrins, are present in animals ranging from nematodes and insects to vertebrates. In this book, we focus on the integrin family, which is shared among all metazoans, but has expanded considerably w

Author : Donald Gullberg
Publisher : Springer
ISBN 13 : 9401791538
Total Pages : 188 pages
Book Rating : 4.33/5 ( download)

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Download or read book I Domain Integrins written by Donald Gullberg and published by Springer. This book was released on 2014-07-14 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.

Author : Klaus Ley
Publisher : Springer Science & Business Media
ISBN 13 : 376437974X
Total Pages : 314 pages
Book Rating : 4.42/5 ( download)

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Download or read book Adhesion Molecules: Function and Inhibition written by Klaus Ley and published by Springer Science & Business Media. This book was released on 2007-08-16 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.