Innovative Imaging Techniques In Preclinical Models Of Neurodegenerative Diseases

Author : Rodolfo Gabriel Gatto
Publisher : Frontiers Media SA
ISBN 13 : 2889743160
Total Pages : 160 pages
Book Rating : 4.62/5 ( download)

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Download or read book Innovative Imaging Techniques in Preclinical Models of Neurodegenerative Diseases written by Rodolfo Gabriel Gatto and published by Frontiers Media SA. This book was released on 2022-02-10 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309134153
Total Pages : 173 pages
Book Rating : 4.56/5 ( download)

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Download or read book Advancing Nuclear Medicine Through Innovation written by National Research Council and published by National Academies Press. This book was released on 2007-09-11 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.

Author : Agustín Ibáñez
Publisher : Frontiers Media SA
ISBN 13 : 2889454940
Total Pages : 217 pages
Book Rating : 4.45/5 ( download)

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Download or read book Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America written by Agustín Ibáñez and published by Frontiers Media SA. This book was released on 2018-06-21 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.

Author : Fabian Kiessling
Publisher : Springer
ISBN 13 : 3319422022
Total Pages : 875 pages
Book Rating : 4.22/5 ( download)

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Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.

Author : David Finkelstein
Publisher : BoD – Books on Demand
ISBN 13 : 9533074639
Total Pages : 412 pages
Book Rating : 4.34/5 ( download)

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Download or read book Towards New Therapies for Parkinson's Disease written by David Finkelstein and published by BoD – Books on Demand. This book was released on 2011-11-02 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The dopamine precursor levodopa is the most valuable drug currently available for the treatment of PD. However for most PD patients, the optimal clinical benefit from levodopa decreases around five to six years of treatment. The aim of the chapters of this book is to work towards an understanding in the mechanisms of degeneration and to develop disease modifying therapies.

Author : Rudi A.J.O. Dierckx
Publisher : Springer Nature
ISBN 13 : 3030531767
Total Pages : 1127 pages
Book Rating : 4.68/5 ( download)

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Download or read book PET and SPECT of Neurobiological Systems written by Rudi A.J.O. Dierckx and published by Springer Nature. This book was released on 2020-09-29 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.

Author : Luca Saba
Publisher : Oxford University Press, USA
ISBN 13 : 0199671613
Total Pages : 585 pages
Book Rating : 4.18/5 ( download)

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Download or read book Imaging in Neurodegenerative Disorders written by Luca Saba and published by Oxford University Press, USA. This book was released on 2015 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text summarizes the latest developments in imaging techniques and other new diagnostic methods as applied to the neurodegenerative disorders.

Author : Stefano Gaburro
Publisher : Frontiers Media SA
ISBN 13 : 2889765989
Total Pages : 328 pages
Book Rating : 4.80/5 ( download)

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Download or read book Home Cage-based Phenotyping in Rodents: Innovation, Standardization, Reproducibility and Translational Improvement written by Stefano Gaburro and published by Frontiers Media SA. This book was released on 2022-07-25 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Irving E. Vega
Publisher : Frontiers Media SA
ISBN 13 : 2889199568
Total Pages : 133 pages
Book Rating : 4.63/5 ( download)

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Download or read book Unraveling Neuroprotective and Neurodegenerative Signals in Neurodegeneration written by Irving E. Vega and published by Frontiers Media SA. This book was released on 2016-09-15 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteinopathy is a collective term used to classified neurodegenerative diseases associated with the progressive accumulation of toxic protein molecules in specific brain regions. Alzheimer’s disease (AD) is a well-known proteinopathy characterize by the accumulation of A peptides and tau proteins. The accumulation of these toxic molecules in the brain starts many years before any clinical presentation, being the onset in the range of 65 to 72 years of age. Therefore, age is considered a risk factor due, in part, to the loss of molecular competence to clear the brain from these toxic protein molecules. This fact, supported by years of research, demonstrates that brain cells activate a neuroprotective mechanism upon detection of a pathobiological signal that (if the detrimental conditions persist) precedes the activation of the neurodegeneration pathway. The progressive brain region specific neuronal death in neurodegenerative diseases also indicates that the transition from neuroprotection to neurodegeneration is individually triggered in cells of the affected brain region. Thus, molecular understanding of the pathophysiology associated with proteinopathies needs to take in consideration this intricate transition process, especially when genomics and proteomics approaches are used.

Author : Jue Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2889637506
Total Pages : 177 pages
Book Rating : 4.08/5 ( download)

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Download or read book Advances of Neuroimaging and Data Analysis written by Jue Zhang and published by Frontiers Media SA. This book was released on 2020-06-05 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: