Influenza Virology

Author : Yohei Yamauchi
Publisher : Humana Press
ISBN 13 : 9781493986774
Total Pages : 663 pages
Book Rating : 4.75/5 ( download)

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Download or read book Influenza Virus written by Yohei Yamauchi and published by Humana Press. This book was released on 2018-08-28 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides researchers with widely used techniques for the study of virology, focusing on molecular biology and imaging to encourage mechanistic investigation of virus-host interactions. Chapters detail a broad range of methods from diagnosis, virus propagation, proteomics, haploid screening, lentiviral screening, virus entry, single molecule RNA imaging, correlative light and electron microscopy (CLEM), EM, light-sheet microscopy, biochemistry, viral transcription, physiological infection models, animal models, in vivo imaging, antigenic evolution, immunology to mathematical modelling. Reviews cover general influenza, clinical trials, both sides of the gain-of-function debate, and computational modelling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Influenza Virus: Methods and Protocols aims to motivate experienced researchers and newcomers in the field and improve our overall understanding of influenza.

Author : Robert G. Webster
Publisher : John Wiley & Sons
ISBN 13 : 111863683X
Total Pages : 684 pages
Book Rating : 4.31/5 ( download)

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Download or read book Textbook of Influenza written by Robert G. Webster and published by John Wiley & Sons. This book was released on 2014-01-06 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain. This new edition is divided into eight key sections, containing chapters co-written by international experts from both the clinical and scientific communities, covering: • Influenza Perspectives • Structure and Replication • Evolution and Ecology • Epidemiology and Surveillance • Immunology • Vaccines and Vaccine Development • Clinical Aspects and Antivirals • Public Health Textbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners.

Author : Yoshihiro Kawaoka
Publisher : Horizon Scientific Press
ISBN 13 : 9781904455066
Total Pages : 367 pages
Book Rating : 4.69/5 ( download)

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Download or read book Influenza Virology written by Yoshihiro Kawaoka and published by Horizon Scientific Press. This book was released on 2006 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: World renowned scientists critically review the most important issues in this rapidly expanding field.

Author : Robert M. Krug
Publisher : Springer Science & Business Media
ISBN 13 : 1461308119
Total Pages : 443 pages
Book Rating : 4.19/5 ( download)

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Download or read book The Influenza Viruses written by Robert M. Krug and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Influenza virus is an important human pathogen, frequently causing widespread disease and a significant loss of life. Much has been learned about the structure of the virus, its genetic variation, its mode of gene expression and replication, and its interaction with the host immu nologic system. This knowledge has the potential of leading to ap proaches for the control of influenza virus. In addition, research on influ enza virus has led to important advances in eukaryotic molecular and cellular biology and in immunology. A major focus of this book is the molecular biology of influenza virus. The first chapter, which serves as an introduction, describes the structure of each of the genomic RNA segments and their encoded pro teins. The second chapter discusses the molecular mechanisms involved in the expression and replication of the viral genome. In addition to other subjects, this chapter deals with one of the most distinctive features of influenza virus, namely the unique mechanism whereby viral messenger RNA synthesis is initiated by primers deaved from newly synthesized host-cell RNAs in the nudeus. Among the most significant accomplish ments in influenza virus research has been the delineation of the three dimensional structure of the two surface glycoproteins of the virus, the hemagglutinin and neuraminidase. This has provided a structural basis for mapping both the antigenic sites and the regions involved in the major biological functions of these two molecules.

Author : P. Palese
Publisher : Springer Science & Business Media
ISBN 13 : 3709187060
Total Pages : 375 pages
Book Rating : 4.67/5 ( download)

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Download or read book Genetics of Influenza Viruses written by P. Palese and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of genetic engineering methods and improved biochemical tech niques, much has been learned about the replication of influenza viruses, their structure and their epidemiology. It appears that the time is ripe to review these efforts and to provide a molecular perspective of influenza virology. It is hoped that this book will stimulate our thinking, help us in designing new experiments, and possibly show avenues leading to the control of the diseases associated with influenza viruses. Peter Palese, New York, N. Y. August 1983 David W. Kingsbury, Memphis, Tenn. Contents List of Contributors. . . . . . . . . . . . . . . . . XV 1. The Evolution of Influenza Viral Genetics - A Perspective. By E. D. Kilbourne. . . . . . . . . . . . . . . . 1 I. Introduction. . . . . . . . . . . . . . . . . 1 II. The Development of Modern Influenza Viral Genetics 2 A. Early Evidence of Genetic Variation in the Laboratory 2 B. Application of Formal Genetic Techniques to Studies of Influenza Virus . . . . . . . 3 C. Genetic Markers. . . . . . . . . 3 D. Development of Plaquing Systems. . . 4 E. The Use of Conditional Lethal Mutants 5 F. New Approaches in Influenza Virus Genetics. 6 1. The Biochemical Identification of Viral Gene Products in the Unambiguous Definition of Viral Inheritance . . . 6 2. Mapping of the Influenza Virus Genome by Correlative Physico-Chemical and Biological Techniques. . . . . . 7 3. The Application of Molecular Biological Techniques to the Study of Viral Genetic Variation. . . . . . . . . 8 4. Oligonucleotide Mapping of Viral RNA's . . . . . . . 8 5. Contribution of Protein and RNA Sequencing to Influenza Viral Genetics-Intragenic Mapping . . . . . . . 8 III. Viral Genetics and the Understanding of Viral Virulence and Pathogenicity . . . . . . . . . . . . . . . . . . .

Author : Sir Charles Herbert Stuart-Harris
Publisher : Mosby Elsevier Health Science
ISBN 13 :
Total Pages : 264 pages
Book Rating : 4.98/5 ( download)

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Download or read book Influenza written by Sir Charles Herbert Stuart-Harris and published by Mosby Elsevier Health Science. This book was released on 1976 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Wiley
Publisher : John Wiley & Sons
ISBN 13 : 1118829476
Total Pages : 220 pages
Book Rating : 4.79/5 ( download)

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Download or read book Influenza Viruses written by Wiley and published by John Wiley & Sons. This book was released on 2013-11-26 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Influenza virus infections are a serious health problem. Each year, about 500 million people are infected by the virus, resulting in about 500,000 deaths worldwide. The occurrence of new influenza subtypes has caused severe pandemics, including the 2009 swine flu (vH1N1). In addition, highly pathogenic viruses, like subtypes H7N7 and H5N1, also called the fowl plague and bird flu, respectively, represent enormous economic threats to livestock farming. This book begins with descriptions of the molecular make-up of influenza viruses, their replication cycles and functions of viral proteins. A history of major influenza pandemics is provided as is a detailed article discussing how viral growth and decay is mathematically modeled to evaluate the biological parameters governing interaction between host and virus. Several laboratory protocols describe how influenza virus is handled and used in animal models to study host-pathogen interactions and test potential new therapies. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of influenza research for students or interdisciplinary collaborators.

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309095042
Total Pages : 431 pages
Book Rating : 4.44/5 ( download)

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Download or read book The Threat of Pandemic Influenza written by Institute of Medicine and published by National Academies Press. This book was released on 2005-04-09 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.

Author : John Carter
Publisher : John Wiley & Sons
ISBN 13 : 0470023864
Total Pages : 383 pages
Book Rating : 4.60/5 ( download)

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Download or read book Virology written by John Carter and published by John Wiley & Sons. This book was released on 2007-08-15 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents an accessible introduction to this fast moving field, providing a comprehensive resource enabling students to understand the key concepts surrounding virology. The authors have produced a text that stimulates and encourages the student through the extensive use of clear, colour-coded diagrams.

Author : E.D. Kilbourne
Publisher : Springer Science & Business Media
ISBN 13 : 1468452398
Total Pages : 370 pages
Book Rating : 4.96/5 ( download)

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Download or read book Influenza written by E.D. Kilbourne and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: My lifetime encompasses the postwar subsidence in the early 1920s of the greatest influenza pandemic in history, direct encounters with FM1 virus at Fort Mon mouth in 1947, the care of influenza patients in the 1950s, the pursuit of the in fluenza virus through the modern pandemics of 1957 and 1968, and a present in which the genes of the virus have dissembled in the DNA of vaccinia virus and Escherichia coli through the wand of "high tech. " If my corpus could be fossilized for archival and archaeological purposes, it would be found to contain immune cells branded with the imprint of the "swine" influenza virus of post-1918 and brain cells no less imprinted with memories of the abortive return of its descendant during America's bicentennial. But before that unlikely event, I wanted to try to make some sense out of this baffling dis ease and its viruses-expecting no definitive revelations but hoping for a sharper definition of problems. Hence this book. It is an audacious act in these days of specialization to essay a book such as this singlehandedly, but I have done so for selfish reasons. I wanted to reexam ine old questions about the nature of influenza and its epidemics in the light of the dazzling advances in molecular biology of the past few years. No virus has been better studied, but few diseases are less well understood.