Influence Of Protein Protein Interactions Ppis On The Outcome Of Viral Infections

Author : Gorka Lasso Cabrera
Publisher : Frontiers Media SA
ISBN 13 : 2889766144
Total Pages : 121 pages
Book Rating : 4.47/5 ( download)

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Download or read book Influence of Protein-Protein Interactions (PPIs) on the Outcome of Viral Infections written by Gorka Lasso Cabrera and published by Frontiers Media SA. This book was released on 2022-08-02 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author : Sriganesh Srihari
Publisher : Morgan & Claypool
ISBN 13 : 1970001534
Total Pages : 295 pages
Book Rating : 4.32/5 ( download)

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Download or read book Computational Prediction of Protein Complexes from Protein Interaction Networks written by Sriganesh Srihari and published by Morgan & Claypool. This book was released on 2017-05-30 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complexes of physically interacting proteins constitute fundamental functional units that drive almost all biological processes within cells. A faithful reconstruction of the entire set of protein complexes (the "complexosome") is therefore important not only to understand the composition of complexes but also the higher level functional organization within cells. Advances over the last several years, particularly through the use of high-throughput proteomics techniques, have made it possible to map substantial fractions of protein interactions (the "interactomes") from model organisms including Arabidopsis thaliana (a flowering plant), Caenorhabditis elegans (a nematode), Drosophila melanogaster (fruit fly), and Saccharomyces cerevisiae (budding yeast). These interaction datasets have enabled systematic inquiry into the identification and study of protein complexes from organisms. Computational methods have played a significant role in this context, by contributing accurate, efficient, and exhaustive ways to analyze the enormous amounts of data. These methods have helped to compensate for some of the limitations in experimental datasets including the presence of biological and technical noise and the relative paucity of credible interactions. In this book, we systematically walk through computational methods devised to date (approximately between 2000 and 2016) for identifying protein complexes from the network of protein interactions (the protein-protein interaction (PPI) network). We present a detailed taxonomy of these methods, and comprehensively evaluate them for protein complex identification across a variety of scenarios including the absence of many true interactions and the presence of false-positive interactions (noise) in PPI networks. Based on this evaluation, we highlight challenges faced by the methods, for instance in identifying sparse, sub-, or small complexes and in discerning overlapping complexes, and reveal how a combination of strategies is necessary to accurately reconstruct the entire complexosome.

Author : Shahid Mukhtar
Publisher : Springer Nature
ISBN 13 : 1071633279
Total Pages : 480 pages
Book Rating : 4.74/5 ( download)

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Download or read book Protein-Protein Interactions written by Shahid Mukhtar and published by Springer Nature. This book was released on 2023-07-14 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume provides a comprehensive collection of classic and cutting-edge methods and techniques in mapping protein-protein interactions. The chapters include a variety of in vitro and in vivo experimental methods covering cell biology, biochemistry, and biophysics. In addition, the book also explores in silico methods including sequence-, structure-, and phylogenetic profile-based approaches as well as gene expression and machine learning methods. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein-Protein Interactions: Methods and Protocols serves as an ideal guide for researchers working in protein science and beyond.

Author : Stefan Canzar
Publisher : Humana
ISBN 13 : 9781493998753
Total Pages : 286 pages
Book Rating : 4.57/5 ( download)

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Download or read book Protein-Protein Interaction Networks written by Stefan Canzar and published by Humana. This book was released on 2020-10-18 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores techniques that study interactions between proteins in different species, and combines them with context-specific data, analysis of omics datasets, and assembles individual interactions into higher-order semantic units, i.e., protein complexes and functional modules. The chapters in this book cover computational methods that solve diverse tasks such as the prediction of functional protein-protein interactions; the alignment-based comparison of interaction networks by SANA; using the RaptorX-ComplexContact webserver to predict inter-protein residue-residue contacts; the docking of alternative confirmations of proteins participating in binary interactions and the visually-guided selection of a docking model using COZOID; the detection of novel functional units by KeyPathwayMiner and how PathClass can use such de novo pathways to classify breast cancer subtypes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary hardware- and software, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Protein-Protein Interaction Networks: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field.

Author : Joseph Loscalzo
Publisher : Harvard University Press
ISBN 13 : 0674436539
Total Pages : 449 pages
Book Rating : 4.34/5 ( download)

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Download or read book Network Medicine written by Joseph Loscalzo and published by Harvard University Press. This book was released on 2017-02-01 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. With contributions from leading experts, Network Medicine introduces this rapidly evolving field of research, which promises to revolutionize the diagnosis and treatment of human diseases.

Author : D. Dhanasekaran
Publisher : CRC Press
ISBN 13 : 1000353141
Total Pages : 863 pages
Book Rating : 4.43/5 ( download)

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Download or read book Microbiome-Host Interactions written by D. Dhanasekaran and published by CRC Press. This book was released on 2021-04-01 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbiota are a promising and fascinating subject in biology because they integrate the microbial communities in humans, animals, plants, and the environment. In humans, microbiota are associated with the gut, skin, and genital, oral, and respiratory organs. The plant microbial community is referred to as "holobiont," and it is influential in the maintenance and health of plants, which themselves play a role in animal health and the environment. The contents of Microbiome-Host Interactions cover all areas as well as new research trends in the fields of plant, animal, human, and environmental microbiome interactions. The book covers microbiota in polar soil environments, in health and disease, in Caenorhabditis elegans, and in agroecosystems, as well as in rice root and actinorhizal root nodules, speleothems, and marine shallow-water hydrothermal vents. Moreover, this book provides comprehensive accounts of advanced next-generation DNA sequencing, metagenomic techniques, high-throughput 16S rRNA sequencing, and understanding nucleic acid sequence data from fungal, algal, viral, bacterial, cyanobacterial, actinobacterial, and archaeal communities using QIIME software (Quantitative Insights into Microbial Ecology). FEATURES Summarizes recent insight in microbiota and host interactions in distinct habitats, including Antarctic, hydrothermal vents, speleothems, oral, skin, gut, feces, reproductive tract, soil, root, root nodules, forests, and mangroves Illustrates the high-throughput amplicon sequencing, computational techniques involved in the microbiota analysis, downstream analysis and visualization, and multivariate analysis commonly used for microbiome analysis Describes probiotics and prebiotics in the composition of the gut microbiota, skin microbiome impact in dermatologic disease prevention, and microbial communities in the reproductive tract of humans and animals Presents information in a reachable way for students, teachers, researchers, microbiologists, computational biologists, and other professionals who are interested in strengthening or enlarging their knowledge about microbiome analysis with next-generation DNA sequencing in the different branches of the sciences

Author : Arvind Ramanathan
Publisher : Frontiers Media SA
ISBN 13 : 2889745457
Total Pages : 138 pages
Book Rating : 4.56/5 ( download)

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Download or read book Computational Approaches to Understand Molecular Mechanisms of SARS-CoV-2 written by Arvind Ramanathan and published by Frontiers Media SA. This book was released on 2022-02-28 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Author :
Publisher : Academic Press
ISBN 13 : 0128143436
Total Pages : 294 pages
Book Rating : 4.38/5 ( download)

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Download or read book Protein-Protein Interactions in Human Disease written by and published by Academic Press. This book was released on 2018-02-17 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein-Protein Interactions in Human Disease, Volume 111, Part B, promotes further research and development in the protein interaction network in order to identify critical proteins involved in the etiology of human diseases and locate new protein targets for drug development. Thus, this volume is of considerable interest to protein chemists, pharmacologists, cell biologists, immunologists, structural biologists, computational biochemists and other researchers working in the field. In addition, these articles would be of great benefit to medical, biology and pharmacology students who specialize in this field. Describes advances in the application of powerful techniques in studying and analyzing protein-protein interactions Ideal for a wide audience of researchers, specialists and students Written by authorities in their field Contains a number of high quality illustrations, figures and tables that support the presented information

Author : Vladimir Uversky
Publisher : John Wiley & Sons
ISBN 13 : 1118135563
Total Pages : 532 pages
Book Rating : 4.63/5 ( download)

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Download or read book Flexible Viruses written by Vladimir Uversky and published by John Wiley & Sons. This book was released on 2011-11-07 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.

Author : Milton W. Taylor
Publisher : Springer
ISBN 13 : 3319077589
Total Pages : 430 pages
Book Rating : 4.81/5 ( download)

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Download or read book Viruses and Man: A History of Interactions written by Milton W. Taylor and published by Springer. This book was released on 2014-07-21 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Milton Taylor, Indiana University, offers an easy-to-read and fascinating text describing the impact of viruses on human society. The book starts with an analysis of the profound effect that viral epidemics had on world history resulting in demographic upheavals by destroying total populations. It also provides a brief history of virology and immunology. Furthermore, the use of viruses for the treatment of cancer (viral oncolysis or virotherapy) and bacterial diseases (phage therapy) and as vectors in gene therapy is discussed in detail. Several chapters focus on viral diseases such as smallpox, influenza, polio, hepatitis and their control, as well as on HIV and AIDS and on some emerging viruses with an interesting story attached to their discovery or vaccine development. The book closes with a chapter on biological weapons. It will serve as an invaluable source of information for beginners in the field of virology as well as for experienced virologists, other academics, students, and readers without prior knowledge of virology or molecular biology.