Inflammation Fundamental Mechanisms

Author : Ley Klaus
Publisher : World Scientific
ISBN 13 : 9813109459
Total Pages : 372 pages
Book Rating : 4.52/5 ( download)

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Download or read book Inflammation: Fundamental Mechanisms written by Ley Klaus and published by World Scientific. This book was released on 2018-03-13 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation is important in many diseases, yet it is hard to find current information on the pertinent cellular and molecular mechanisms of inflammation. This book is a current and authoritative review of various aspects of inflammation in mammalian organisms. Basic principles, including regulation by cytokines, lipid mediators, reactive oxygen species and leukocyte recruitment are followed by chapters on integrative aspects of inflammation, such as neutrophil extracellular traps, sepsis and granulomatous inflammation. Contents: TNF Superfamily in Inflammation (Marisol Veny, Richard Virgen-Slane and Carl F Ware) Complement as a Mediator of Inflammation (B Paul Morgan) Lipids and Inflammation (Valerie B O'Donnell, Robert C Murphy and Garret A FitzGerald) Reactive Oxygen Species (Ulla G Knaus) Leukocyte Adhesion (Klaus Ley and Zhichao Fan) Neutrophil Extracellular Traps (Tobias A Fuchs, Abdul Hakkim and Constantin F Urban) Sepsis (Jamison J Grailer, Matthew J Delano and Peter A Ward) Granulomatous Inflammation (Marc Hilhorst, Gene Hunder, Jörg Goronzy and Cornelia Weyand) Readership: Graduate students, medical doctors/ practitioners, researchers, pathologists and nutritionists in medicine and healthcare. Keywords: Cytokines;IL-1;TNF;Lipid Mediators;Bradykinin and Neuropeptides;Leukocyte Adhesion;Angiogenesis;Degranulation;Antimicrobial Peptides;Neutrophil Extracellular Traps (NETs);Pharmacologic Modulation of Inflammation;Sepsis;Complement;Oxygen Radicals;Reperfusion Injury;Resolution of Inflammation;Atherosclerosis;Granulomatous Inflammation;Inflammatory Bowel DiseaseReview: Key Features: Up-to-date resource Comprehensive review of the various facets of inflammation

Author : Charles N. Serhan
Publisher : Cambridge University Press
ISBN 13 : 1139936670
Total Pages : 489 pages
Book Rating : 4.75/5 ( download)

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Download or read book Fundamentals of Inflammation written by Charles N. Serhan and published by Cambridge University Press. This book was released on 2010-04-26 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

Author : D. Neil Granger
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041656
Total Pages : 99 pages
Book Rating : 4.57/5 ( download)

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Download or read book Inflammation and the Microcirculation written by D. Neil Granger and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References

Author : Leonard H. Sigal
Publisher : McGraw-Hill Companies Health Professions Division
ISBN 13 :
Total Pages : 844 pages
Book Rating : 4.41/5 ( download)

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Download or read book Immunology and Inflammation written by Leonard H. Sigal and published by McGraw-Hill Companies Health Professions Division. This book was released on 1994 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated introduction to the basic science & clinical applications of contemporary immunology. The book has four basic aims: (1) To ground the student in the basic principles of immunology (2) To demonstrate how immunologic mechanisms prevent & produce human disease (3) To foster problem-solving skills (4) To expose the student to the new technology in use in research, & demonstrate its applications to clinical medicine.

Author : Masayuki Miyasaka
Publisher : Springer
ISBN 13 : 4431560688
Total Pages : 702 pages
Book Rating : 4.85/5 ( download)

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Download or read book Chronic Inflammation written by Masayuki Miyasaka and published by Springer. This book was released on 2016-11-01 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with the most up-to-date information on cutting-edge research concerning chronic inflammation. We now know that when inflammation becomes chronic, it acts as a strong disease-promoting factor in a variety of disorders including arteriosclerosis, obesity, cancer, and Alzheimer disease. Chronic inflammation is hence called as the “silent killer”; it upsets the body’s homeostatic mechanism insidiously. In spite of these developments, we know very little about the mechanism underlying chronic inflammation. Particularly, we do not know precisely what induces chronic inflammation or what promotes its prolongation in a spatiotemporal framework. Neither do we have clear knowledge about how chronic inflammation destroys various tissues or how it predisposes individuals to many different diseases. To make the situation worse, we have no effective treatment against chronic inflammation. Since 2010, two major research programs (CREST and PRESTO) aimed at clarifying the mechanisms underlying chronic inflammation were launched in Japan, and investigators of different research areas with a brilliant track record were selected by their research proposals. Subsequently they have made their best efforts to answer the conundrum concerning chronic inflammation. This book is a compendium of such research efforts. In each chapter, the CREST- or PRESTO-funded researchers summarize their original work concerning mechanisms of induction, progression, or resolution underlying chronic inflammation. The most emphasized characteristic is the molecular aspect of chronic inflammation. The book thus presents the most recent progress made in the molecular understanding of chronic inflammation.

Author : Adriano Rossi
Publisher : Springer Science & Business Media
ISBN 13 : 376437506X
Total Pages : 246 pages
Book Rating : 4.65/5 ( download)

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Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Author : Charles N. Serhan
Publisher : Cambridge University Press
ISBN 13 : 0521887291
Total Pages : 489 pages
Book Rating : 4.98/5 ( download)

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Download or read book Fundamentals of Inflammation written by Charles N. Serhan and published by Cambridge University Press. This book was released on 2010-04-26 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.

Author : Robert Fitridge
Publisher : University of Adelaide Press
ISBN 13 : 1922064009
Total Pages : 589 pages
Book Rating : 4.04/5 ( download)

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Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Author : Parag Jain
Publisher : Springer
ISBN 13 : 813222163X
Total Pages : 175 pages
Book Rating : 4.30/5 ( download)

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Download or read book Inflammation: Natural Resources and Its Applications written by Parag Jain and published by Springer. This book was released on 2014-12-04 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation is the very natural process of our body; it does its work immediately and smoothly along with lots of helpers. Inflammation is linked to immune system as acute inflammatory or pro-inflammatory phase through macrophage activation. This book is for researchers and scholars in the field of life sciences and medical sciences. The book contains all inflammatory sources around the world. It emphasizes on anti-inflammatory sources along with its active inflammatory constituents and other medicinal uses with authentic references. Anti-inflammation is a kind of activity with is found in nearly all of the natural sources used for major biological activities. So, the book helps them to correlate their activity of interest with anti-inflammatory source. The present work deals with illustrative representation of inflammation, causes of inflammation, inflammatory mediators, anti-inflammatory sources other uses and inflammation and lifestyle. It mainly provides the researchers the updated information from the ancient to the most recent ongoing research on inflammation. This book imparts pace to their idea of thinking, assist to make clear predictions before proceeding to research. The introduction includes natural sources of inflammation and its benefits; the sources are from plant, animal and marine. The book tells how these sources are useful for us to cure several diseases and opens new path for further research. Inflammation part of the book is well presented along with its phases, types and other diseases interrelated with inflammation. Inflammatory mediators, the foremost player of inflammation are defined in a very pleasant and convenient manner. The chapter includes both cell- derived and plasma - derived mediators illustratively with their synthesis and action. Natural source of anti-inflammation is the heart chapter of this book which contains all anti-inflammation sources from plants, marine and animals. This chapter also contains short description of most of the sources, its availability and uses. The authors have also added inflammatory models for assessment of biological activities of natural sources both in vitro and in vivo. Inflammation free lifestyle is described very nicely in the book. The contents are very specific and relevant to its topic; all the data provided is unique and useful. The anti-inflammatory table includes sources, plant parts used, active constituents and other uses. This data provides ample information regarding anti-inflammatory research and innovation. The highlights of this book shall be: -Describes almost all anti-inflammatory sources around the globe at one place in a more convenient tabulated form -Illustrative representation makes the book more attractive and interactive

Author : Benjamin W. Zweifach
Publisher : Academic Press
ISBN 13 : 1483261700
Total Pages : 950 pages
Book Rating : 4.06/5 ( download)

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Download or read book The Inflammatory Process written by Benjamin W. Zweifach and published by Academic Press. This book was released on 2014-05-12 with total page 950 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Inflammatory Process focuses on the approaches, methodologies, and technologies involved in the study of the inflammatory process, including capillary structure, tissue injury, and inflammatory response. The selection first offers information on the experimental approach to inflammation, ultrastructural and biochemical consequences of cell injury, and ultrastructural basis of capillary permeability. Discussions focus on permeability of capillaries, cytoplasm, nucleus, gross pathology of inflammation, light microscope and the study of inflammation, and the physiologic approach to problems of inflammation. The text then elaborates on the microvascular aspects of tissue injury and the sticking and emigration of white blood cells in inflammation. The book examines neutrophil and eosinophil leucocytes, "life history" and functions of lymphocytes, and metabolism and physiology of mononuclear phagocytes. Topics include inflammatory response, biochemistry and metabolism, special relationships to bacteria and viruses, and origins and early development of lymphocytes. The text also ponders on the role of lysosomes in tissue injury, hemostatic mechanisms in tissue injury, and anti-inflammatory agents. The selection is a vital source of data for researchers interested in the inflammatory process.